Search results for "screening"
showing 10 items of 1150 documents
Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular …
2018
Fluorescent 4-ethylthio-1,8-naphthalimides containing rhodium(I) N-heterocyclic carbene (NHC) and ruthenium (II) NHC fragments were synthesised and evaluated for their antiproliferative effects, cellular uptake and DNA-binding activity. Both types of organometallics triggered ligand dependent efficient cytotoxic effects against tumor cells with the rhodium(I) NHC derivatives causing stronger effects than the ruthenium (II) NHC analogues. Antiproliferative effects could also be observed against several pathogenic Gram-positive bacterial strains, whereas the growth of Gram-negative bacteria was not substantially affected. Cellular uptake was confirmed by atomic absorption spectroscopy as well…
Personal and Social Consequences of Psychotropic Substance Use: A Population-Based Internet Survey
2022
Background and objectives: Drug abuse has become a major worldwide health concern among all age groups. The present study analyses substance misuse and its social and personal consequences using a population-based internet survey in Spain. Materials and Methods: Screening for drug abuse (of alcohol, marijuana/hashish and psychostimulants) and its related risks and problems was performed using the Car, Relax, Alone, Forget, Friends, Trouble (CRAFFT) score. Socio-demographic factors, depressive, anxiety and stress symptoms as well as health habits were also evaluated. We used Linear regression methods to compare each variable’s individual contribution so as to determine which one best explain…
Endomicroscopy of Colon Pathology
2007
Colorectal cancer is still one of the leading causes of cancer-related death in the Western world. Screening colonoscopy is widely accepted as the gold standard for early diagnosis of cancer. The prognosis for patients with colonic neoplasms is strictly dependent on the depth of infiltration and therefore depends on early detection of pre-invasive and neoplastic changes. Early detection makes it possible to cure the patient by means of immediate endoscopic resection.
Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy.
2018
0.5-1% of the world's population is affected by vitiligo, a disease characterized by a gradual depigmentation of the skin. Baicalin and berberine are natural compounds with beneficial activities, such as antioxidant, anti-inflammatory and proliferative effects. These polyphenols could be useful for the treatment of vitiligo symptoms, and their efficacy can be improved by loading in suitable carriers. The aim of this work was to formulate and characterize baicalin or berberine loaded ultradeformable vesicles, and demonstrate their potential as adjuvants in the treatment of vitiligo. The vesicles were produced using a previously reported simple, scalable method. Their morphology, size distrib…
Cytotoxic Activity of Some Natural and Synthetic ent-Kauranes
2007
Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 microM, respectively. These two 1-analogues are promising lead compounds for further investigation.
Kolorektālā vēža skrīninga atsaucību veicinošie faktori ģimenes ārsta praksē
2020
Aktualitāte.Kolorektālais vēzis (KRV) jeb zarnu vēzis ir plaši sastopams ne tikai Latvijā, bet gan visā pasaulē. Globāli tas ir otrs biežāk diagnosticētais vēzis un mirstības ziņā KRV ierindojas 3.vietā. 2018. gadā visā pasaulē tika diagnosticēti 1,8 miljoni kolorektālā vēža gadījumu, un 861,000 pacientu miruši vēža dēļ, balstoties uz Pasaules Veselības Organizācijas GLOBOCAN datiem. 2019.gadā tikai 15% no Latvijas mērķa grupas iedzīvotājiem veikuši KRV skrīningu. Darba mērķis ir noskaidrot motivējošos faktorus, kuri veicinājuši iedzīvotājus piedalīties valsts organizētā kolorektālā vēža skrīninga programmā. Materiāli un metodes. Tika izveidota neanonīma, pašaizpildāma, papīra formātā anket…
Implementare le politiche sanitarie a livello regionale per l'eliminazione dell'epatite C ai tempi del COVID-19
2022
Viral hepatitis C is an important public health problem and its elimination by 2030, defined by the World Health Organization, is an ambitious goal. The chance of free screening for HCV infection represents an important achievement that requires a successful State-Regions coordination and an effective regional organisation, that guarantees an interdisciplinary course between local and specialized healthcare. A structured communication program to increase the sensitivity of target populations as well as health professionals is the key for success. The implementation of the proactive screening, defined by the Milleproroghe Law, is crucial because it will define the tracks for the whole HCV co…
Biodiversity and dairy traits of indigenous milk lactic acid bacteria grown in presence of the main grape polyphenols
2020
ABSTRACT The present work was developed to select lactic acid bacteria (LAB) to be used as starter cultures in functional cheese production. The indigenous milk LAB populations were isolated from fermented raw ewes’ milks (four bulks) added with 0.5 mg/mL of nine polyphenols commonly found in winery by-products. After 48 h of fermentation, all milks were characterized by an increase of LAB levels of about 3–4 Log cycles. All different colonies were purified and characterized for the main physiological and biochemical traits and then differentiated genetically at strain level and identified. Ten species belonging to the LAB genera Lactobacillus, Streptococcus, Enterococcus, Leuconostoc and L…
Laterolateral teleradiography of the skull as a screening method for OSA/OSAS, in patients in orthodontic treatment
2019
Aim: Obstructive sleep apnea syndrome (OSAS) is the most common type of sleep apnea and it is caused by complete or partial obstruction of the upper airway. Adenotonsillar hypertrophy, obesity, cranio-facial anomalies and neuromuscular diseases are the main risk factors for the development of OSAS in the pediatric age. Specially several studies identify the relationship between respiratory disorders in sleep and obesity, and, in particular, between OSAS and obesity, designing a prevalence of OSAS among obese subjects between 14 and 78%. The diagnosis of OSAS in the child is of great importance as it can lead to neurocognitive and behavioral complications, growth retardation, systemic arteri…
Static and non-static vector screening masses
2016
Thermal screening masses of the conserved vector current are calculated both in a weak-coupling approach and in lattice QCD. The inverse of a screening mass can be understood as the length scale over which an external electric field is screened in a QCD medium. The comparison of screening masses both in the zero and non-zero Matsubara frequency sectors shows good agreement of the perturbative and the lattice results. Moreover, at $T\approx 508\mathrm{MeV}$ the lightest screening mass lies above the free result ($2\pi T$), in agreement with the $\mathcal{O}(g^2)$ weak-coupling prediction.