Search results for "secret"
showing 10 items of 1132 documents
Retention mechanisms for ER and Golgi membrane proteins
2014
Unless there are mechanisms to selectively retain membrane proteins in the endoplasmic reticulum (ER) or in the Golgi apparatus, they automatically proceed downstream to the plasma or vacuole membranes. Two types of coat protein complex I (COPI)-interacting motifs in the cytosolic tails of membrane proteins seem to facilitate membrane retention in the early secretory pathway of plants: a dilysine (KKXX) motif (which is typical of p24 proteins) for the ER and a KXE/D motif (which occurs in the Arabidopsis endomembrane protein EMP12) for the Golgi apparatus. The KXE/D motif is highly conserved in all eukaryotic EMPs and is additionally present in hundreds of other proteins of unknown subcellu…
Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dl…
2013
Background In-situ hybridisation studies demonstrate that Notch receptors and ligands are expressed in granulosa cells (GCs) and in the theca layer vasculature of growing follicles. Notch signaling involves cell-to-cell interaction mediated by transmembrane receptors and ligands. This signaling pathway may represent a novel intraovarian regulator of gonadotropin-dependent follicular development to the preovulatory stage. We hypothesized that blocking Notch pathways would disrupt follicular maturation in the mouse ovary. Methods Hypophysectomized CD21 female mice were administered pregnant mare serum gonadotropin (PMSG) for 3 days to stimulate follicular development. In one experiment, a pan…
Wharton’s Jelly Mesenchymal Stem Cells as Candidates for Beta Cells Regeneration: Extending the Differentiative and Immunomodulatory Benefits of Adul…
2010
Mesenchymal stem cells (MSC) are uniquely capable of crossing germinative layers borders (i.e. are able to differentiate towards ectoderm-, mesoderm- and endoderm-derived cytotypes) and are viewed as promising cells for regenerative medicine approaches in several diseases. Type I diabetes therapy should potentially benefit from such differentiated cells: the search for alternatives to organ/islet transplantation strategies via stem cells differentiation is an ongoing task, significant goals having been achieved in most experimental settings (e.g. insulin production and euglycaemia restoration), though caution is still needed to ensure safe and durable effects in vivo. MSC are obtainable in …
Delivery and therapeutic potential of human granzyme B
2010
Summary: Granzyme B (GzmB) is used by cytotoxic lymphocytes as a molecular weapon for the defense against virus-infected and malignantly transformed host cells. It belongs to a family of small serine proteases that are stored in secretory vesicles of killer cells. After secretion of these cytolytic granules during killer cell attack, GzmB is translocated into the cytosol of target cells with the help of the pore-forming protein perforin. GzmB has adopted similar protease specificity as caspase-8, and once delivered, it activates major executioner apoptosis pathways. Since GzmB is very effective in killing human tumor cell lines that are otherwise resistant against many cytotoxic drugs and …
Influence of Macrophage Activation on the Synthesis of Complement Components C2, C3, C4
1982
Macrophages are a major site of complement synthesis. In the guinea pig production of complement components C1, C2, C4, C3, D, B, and P by peritoneal macrophages has been demonstrated (reviewed in Ref. 1). Whereas marked differences exist in biological activity between resident, elicited and activated macrophages (2), we investigated whether this holds true for the synthesis and secretion of complement components C2, C3, and C4.
Utilización del Integrated Semen Analysis System (ISAS)® para el análisis morfométrico espermático humano y su significado en las técnicas de reprodu…
2005
Use of the integrated semen analysis system (ISAS ® ) for morphometric analysis and its role in assisted reproduction technologies
Organeigene Proteine im Sekret des Collum uteri
1971
Kaninchen wurden gegen menschliches Cervixsekret immunisiert. Sie entwickelten danach Antikorper gegen menschliche Serumproteine und organeigene Antigene aus der Cervix und dem Samenplasma, die nicht im Serum enthalten sind. Durch stufenweise Absorption konnte herausgearbeitet werden, das Cervixsekret und Sekret der Samenblasen zwei gemeinsame Antigenkomponenten besitzen. Die Cervix produziert daruber hinaus noch zwei weitere Antigensubstanzen, die weder im menschlichen Samenplasma noch im Blutserum enthalten sind.
Psychometric Comparisons of Benevolent and Corrective Humor across 22 Countries: The Virtue Gap in Humor Goes International
2018
Recently, two instances of virtue-related humor: benevolent and corrective, have been introduced. Benevolent humor treats human weaknesses and wrongdoings benevolently, while corrective humor aims at correcting and bettering them. Twelve marker items for benevolent and corrective humor (BenCor) were developed, and it was demonstrated that they fill the gap between humor as temperament and virtue. The present study investigates responses to the BenCor from 25 samples in 22 countries (overall N = 7, 226). The psychometric properties of the BenCor were found to be sufficient in most of the samples, including internal consistency, unidimensionality, and factorial validity. Importantly, benevole…
Freemasonry and Education in Contemporary Spain. Between Tolerance and Dogmatism
2017
Resumen:En este trabajo vamos a centrarnos casi en exclusiva en las iniciativas planteadas por diversas entidades masónicas, ya sean potencias, logias regionales o talleres, más que en personas exponiendo solamente algunas de las experiencias más relevantes y que ejemplifican mejor las intervenciones y actuaciones de la masonería española en relación con los enfoques descritos. La visibilidad que han alcanzado otras parcelas e interpretaciones del comportamiento, de los masones en particular y de las iniciativas de la masonería como institución, no nos deben ocultar la faceta desarrollada en torno a la educación. ¿Qué importancia tuvo el proceso formativo llevado a cabo en los talleres masó…
Semblanza de José Antonio Ayala Pérez
2014
José Antonio Ayala Pérez (1935-2014).