Search results for "semen"
showing 10 items of 1278 documents
Cautionnement. Redressement judiciaire, Absence de déchéance du terme, Renonciation de la caution, Clause non écrite
1995
International audience; (Civ. 1re, 24 janv. 1995, Epoux Lemaire c/ Sté Union bancaire du Nord)
Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts
2020
Basement membranes (BMs) are specialised extracellular matrices that provide structural support to tissues as well as influence cell behaviour and signalling. Mutations in COL4A1/COL4A2, a major BM component, cause a familial form of eye, kidney and cerebrovascular disease, including stroke, while common variants in these genes are a risk factor for intracerebral haemorrhage in the general population. These phenotypes are associated with matrix defects, due to mutant protein incorporation in the BM and/or its absence by endoplasmic reticulum (ER) retention. However, the effects of these mutations on matrix stiffness, the contribution of the matrix to the disease mechanism(s) and its effects…
Different adhesins for type IV collagen on Candida albicans: identification of a lectin-like adhesin recognizing the 7S(IV) domain
2001
Adherence of the opportunistic pathogen Candida albicans to basement membrane (BM) proteins is considered a crucial step in the development of candidiasis. In this study the interactions of C. albicans yeast cells with the three main domains of type IV collagen, a major BM glycoprotein, were analysed. C. albicans adhered to the three immobilized domains by different mechanisms. Adhesion to the N-terminal cross-linking domain (7S) required the presence of divalent cations, whereas interaction with the central collagenous domain (CC) was cation-independent. Recognition of the C-terminal non-collagenous domain (NC1) was partially cation-dependent. Binding inhibition assays with the correspondi…
Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen
2019
BACKGROUND: Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors influencing risk remain largely unknown.METHODS: To identify genetic variants predisposing to diabetic kidney disease, we performed genome-wide association study (GWAS) analyses. Through collaboration with the Diabetes Nephropathy Collaborative Research Initiative, we assembled a large collection of type 1 diabetes cohorts with harmonized diabetic kidney disease phenotypes. We used a spectrum of ten diabetic kidney disease definitions based on albuminuria and renal function.RESULTS: Our GWAS meta-analysis included association result…
Vitamin A deficiency disturbs collagen IV and laminin composition and decreases matrix metalloproteinase concentrations in rat lung. Partial reversib…
2011
Vitamin A is essential for lung development and pulmonary cell differentiation. Its deficiency leads to altered lung structure and function and to basement membrane architecture and composition disturbances. Previously, we showed that lack of retinoids thickens the alveolar basement membrane and increases collagen IV, which are reversed by retinoic acid, the main biologically active vitamin A form. This study analyzed how vitamin A deficiency affects the subunit composition of collagen IV and laminin of lung basement membranes and pulmonary matrix metalloproteinase content, plus the recovering effect of all-trans-retinoic acid. Male weanling pups were fed a retinol-adequate/-deficient diet …
Characterization and Expression of Multiple Alternatively Spliced Transcripts of the Goodpasture Antigen Gene Region. Goodpasture Antibodies Recogniz…
1995
Collagen IV, the major component of basement membranes, is composed of six distinct alpha chains (alpha 1-alpha 6). Atypically among the collagen IV genes, the exons encoding the carboxyl-terminal region of the human alpha 3(IV) chain undergo alternative splicing. This region has been designated as the Goodpasture antigen because of its reactivity in the kidney and lung with the pathogenic autoantibodies causing Goodpasture syndrome. The data presented in this report demonstrate that, in human kidney, the gene region encompassing the Goodpasture antigen generates at least six alternatively spliced transcripts predicting five distinct proteins that differ in their carboxyl-terminus and retai…
L'éducation aux valeurs à l'épreuve du socle commun
2010
Having examined values in education since earliest times on the one hand and the formal structuring of curricula throughout the XIXth century on the other hand, we will show how Jules Ferry's programmes are at the junction of two different approaches to moral education. Therefore, we will consider the main changes which structured the way it was taught throughout the XXth century. In France, the setting up of a base for common knowledge and common skills sheds a new light on social and civic skills, autonomy and initiative. These 6th and 7th pillars will compare favourably with other educational programmes, moral and religious, particularly in French-speaking Belgium as well as in Quebec. C…
Note critique de "l'efficacité des collèges, sociologie de l'effet établissement", d'Olivier Cousin
1999
International audience
La parole pour évaluer
2001
En 1997-1998, dans le cadre d'un projet de la Commission Européenne, une centaine de collèges ou lycées des pays de l'Union (dont neuf français), ont évalué eux-mêmes la qualité de leur fonctionnement selon canevas commun, mais assez peu contraignant.
Article 40. Commission d'un agent immobilier, Mandat antérieur au jugement d'ouverture, Acte de vente postérieur au jugement d'ouverture, Fait généra…
1998
International audience; (Com. 17 févr. 1998, SA Stesa c/ Gourdain ès qual. et autres)