Search results for "sense"
showing 10 items of 3076 documents
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs
In Cystic fibrosis (CF) disease nonsense mutations in the CFTR gene cause the absence of the CFTR protein expression and a more severe form of the disease. About 10% of patient affected by CF show a nonsense mutation. A potential treatment of this alteration is to promote translational readthrough of premature termination codons (PTCs) by translational readthrough inducing drugs such as Ataluren (1). We reported a rationale for Ataluren promoted readthrough of PTCs by computational approach and GFP-reporter cell-based assay (2) and the observed enhancement of readthrough activity by some Ataluren derivatives (3, 4). In this context we aimed to compare the 1,2,4-oxadiazole core of Ataluren w…
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models
The effects of microwave radiation generated by mobile phones on the tear film
2021
Abstract Electromagnetic radiation (ER) emitted by mobile phones and other modern devices has potentially harmful effects on ocular tissue. Their effects on the eye surface and tear film are little known so far. The aim of this paper was to investigate the effects of ER emitted by the phone mobile on the tear film. For this study, we selected a total of 50 subjects, young, healthy, without chronic treatment, who are not contact lens wearers and who have no history of ophthalmic surgery. Schirmer I test, tear pH and tear ferning test (TFT) were performed on all subjects before (“-pre”) being exposed to ER emitted by the mobile phone and after (“-post”) exposure for 5 minutes, the pH and TFT …
Evidence of neonatal memory of odor configuration
2013
The perception of some mixtures of odorants engages configural abilities, i.e. the perception of these mixtures as single odor objects. For instance, data in human adults demonstrated that a mixture of two odorants (AB), one smelling like strawberry and the other like caramel, generates the configural perception of the odor of pineapple (Le Berre et al., 2008; Barkat et al., 2012). Configural processing may be adaptive also for young organisms, to which rapid extraction of chemical information from the maternal environment, highly complex, is a prerequisite to survival. Thus, results in newborn rabbits suggest the perception of a unique odor in the AB mixture (smelling like configural pinea…
Système olfactif et neurobiologie
2006
Les connaissances neurobiologiques sur l’odorat progressent désormais rapidement depuis la découverte des récepteurs des odorants, remarquables par leur grand nombre et leur diversité. Des réponses sont maintenant apportées aux questions posées par les propriétés originales de la perception olfactive dont beaucoup sont déterminées dès le niveau de l’organe olfactif, et sont fortement déterminées par la génétique. Les connaissances génétiques sur les récepteurs dévoilent une considérable réduction du nombre de gènes olfactifs fonctionnels dans l’espèce humaine et alimentent une réflexion sur l’évolution de l’odorat. Autre avancée riche de promesses : l’application à l’olfaction des méthodes …
PARI 2010-2011 - Projet DINOS "Innovinaroma" ou Mélanges d'odorants et milieux complexes
2011
L'idée est de réaliser une méta-analyse non ciblée de données d'origines multiples afin de prendre en compte à la fois les résultats de l'analyse sensorielle établie sur le concept de typicité mais aussi celles de l'olfactométrie séparative, de l'analyse semi-quantitative, de la chimie des odorants identifiés, de la psychophysique et de l'aromatique alimentaire. Le statut de composés clés porteurs de typicité aromatique, relève de leur présence en mélange dans des gammes de concentrations et dans un environnement à la fois complexe et diversifié propre à la catégorie sensorielle cible. Les approches, dont le but était de faire émerger un tel groupe d'odorants, jusqu'ici trop simplistes ou t…
Differences in children's school success and family backgrounds : a comparative case study of pupils' performance in entrance examination in Ibadan, …
2013
This study reviewed the socio-economic backgrounds of pupils from various family structures (Monogamous, polygamous, single-parent and orphan children) against their academic performances in Ibadan North-East municipality of Ibadan, Nigeria. The diverse contending studies on how the socio-economic backgrounds of these family structures aid children’s academic attainments were examined. The data for this study was gathered in April, 2012. The study employed both qualitative and quantitative data collection method. A total of two hundred and twenty pupils between the ages of 10 to15 in junior secondary schools were sampled, N=220 and 8 teachers were interviewed from the various pupils’ school…
Choroidal thickness and morphology analysed by optical coherence tomography as a method to approach diabetic ocular disease prognosis and progression
2019
TÍTULO ESPESOR COROIDEO Y MORFOLOGÍA ANALIZADO POR TOMOGRAFÍA DE COHERENCIA ÓPTICA COMO MÉTODO PARA ABORDAR LA PROGNOSIS Y LA PROGRESIÓN DE LA ENFERMEDAD OCULAR DIABÉTICA INTRODUCCIÓN La evidencia clínica in vivo de coroidopatía diabética (DC) ha sido difícil de demostrar clínicamente debido a la falta de medios para visualizar la coroides. Los avances de la tecnología de la tomografía de coherencia óptica (OCT) permitieron la visualización in vivo de la coroides. Los resultados controvertidos en la Diabetes para el grosor coroideo (CT) y la falta de identificación de los cambios morfológicos hacen que la DC identificada con OCT aún no se conozca. PROPÓSITO Evaluar si la medición por CT sol…
Fostering learning opportunities through employee participation amid organizational change
2014
Health care organizations are facing rapid changes, frequently involving modification of existing procedures. The case study reported here examined change processes and learning in a health care organization. The organizational change in question occurred in the emergency clinic of a Finnish central hospital where a new action model for shift-specific nursing supervision was being introduced. The aim of this study was to investigate some of the employee participation and learning opportunities amid this organizational change. The data collection was ethnographically informed, and the data consisted of audio-recorded and observed meetings, observations of the new action model, and field inte…
Intensified job demands, stress of conscience and nurses' experiences during organizational change
2022
Background:Nurses frequently face ethically demanding situations in their work, and these may lead to stress of conscience. Working life is currently accelerating and job demands are intensifying. These intensified job demands include (1) work intensification, (2) intensified job-related planning demands, (3) intensified career-related planning demands, and (4) intensified learning demands. At the same time, many healthcare organizations are implementing major organizational changes that have an influence on personnel.Aim:The aim of the study was to investigate the association between intensified job demands and stress of conscience, and whether their association is moderated by organizatio…