Search results for "sequences"
showing 10 items of 359 documents
Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia
2020
Contains fulltext : 218279.pdf (Publisher’s version ) (Open Access) Patients with acute myeloid leukemia (AML) harboring FLT3 internal tandem duplications (ITDs) have poor outcomes, in particular AML with a high (>/=0.5) mutant/wild-type allelic ratio (AR). The 2017 European LeukemiaNet (ELN) recommendations defined 4 distinct FLT3-ITD genotypes based on the ITD AR and the NPM1 mutational status. In this retrospective exploratory study, we investigated the prognostic and predictive impact of the NPM1/FLT3-ITD genotypes categorized according to the 2017 ELN risk groups in patients randomized within the RATIFY trial, which evaluated the addition of midostaurin to standard chemotherapy. The 4 …
Engaging in upward and downward comparisons as a determinant of relative deprivation at work
2003
A longitudinal study was conducted among 93 nurses to determine the role of comparing one's performance with that of one's colleagues in the increase versus decrease of perceived relative deprivation at work over a period of one year. Relative deprivation at T2 had increased particularly among those high in social comparison orientation (Gibbons & Buunk, 1999) who at T1 (1) more frequently engaged in upward comparisons; (2) more frequently derived positive as well as negative feelings from such comparisons; and (3) more frequently derived negative feelings from downward comparison. Moreover, engaging in downward comparison also led to an increase in perceived relative deprivation at T2.…
STR genotyping and mtDNA sequencing of latent fingerprint on paper
2003
A systematic study was conducted to investigate whether DNA can be successfully extracted from latent fingerprints deposited on ordinary paper and analysed using short tandem repeat profiling and mitochondrial DNA sequencing. In order to evaluate the performance of latent fingerprint analysis in a criminal case, experiments with varying conditions were carried out to improve our understanding of low copy number (LCN) DNA typing. After optimising the extraction methods to achieve increased sensitivity, the examination of touched paper can routinely yield the STR profile of the individual who has touched it. A fingerprint can therefore be considered as a potential source of DNA for genetic id…
Fostering creative thinking : the role of primary teachers
2014
Τα τελευταία χρόνια παρατηρείται μια αυξανόμενη απαίτηση για δημιουργικότητα σε όλους τους τομείς της ανθρώπινης δραστηριότητας. Η πρωτοβάθμια εκπαίδευση πασχίζει να συμβαδίσει με τις νέες κοινωνικοοικονομικές ανάγκες και να προετοιμάσει τους δημιουργικούς πολίτες του μέλλοντος. Αν και οι εκπαιδευτικοί της πρωτοβάθμιας εκπαίδευσης παίζουν καθοριστικό ρόλο, άλλοτε θετικό και άλλοτε αρνητικό, στην καλλιέργεια της δημιουργικότητας των μαθητών, λίγες έρευνες έχουν διεξαχθεί σχετικά με τη συμβολή τους στην καλλιέργεια της δημιουργικής σκέψης των μαθητών και τις απόψεις τους για το θέμα αυτό. Η θεμελιωμένη γνώση (situated knowledge) των Ελλήνων εκπαιδευτικών πρωτοβάθμιας εκπαίδευσης και η εμπειρί…
The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two re…
1995
AbstractPeroxisome proliferators (PPs) are non-genotoxic carcinogens in rodents. They can induce the expression of numerous genes via the heterodimerization of two members of the steroid hormone receptor superfamily, called the peroxisome proliferator-activated receptor (PPAR) and the 9-cis retinoic acid receptor (RXR). Many of the PP responsive genes possess a peroxisome proliferator response element (PPRE) formed by two TGACCT-related motifs. The bifunctional enzyme (HD) PPRE contains 3 such motifs, creating DR1 and DR2 sequences. PPAR and RXR regulate transcription via the DR1 element while DR2 modulates the expression of the gene via auxiliary factors in HepG2 cells.
Transcriptional regulation and expression of CYP3A4 in hepatocytes.
2007
CYP3A4 is the most abundantly expressed drug-metabolizing P450 enzyme in human liver and contributes to the metabolism of a large number of drugs in use today. CYP3A4 is constitutively expressed in adult hepatocytes but it can also be transcriptionally induced by a variety of structurally diverse xenochemicals. CYP3A4 strongly contributes to the important variability in the therapeutic and toxic effects of drugs owing to the major role it plays in xenobiotic metabolism and the large intra- and inter-individual variability to which it is subjected. The functional examination of up to 13 kb of the CYP3A4 5'-flanking region has revealed that the regulation of this gene is a complex issue, with…
Minimum Description Length Based Hidden Markov Model Clustering for Life Sequence Analysis
2010
In this article, a model-based method for clustering life sequences is suggested. In the social sciences, model-free clustering methods are often used in order to find typical life sequences. The suggested method, which is based on hidden Markov models, provides principled probabilistic ranking of candidate clusterings for choosing the best solution. After presenting the principle of the method and algorithm, the method is tested with real life data, where it finds eight descriptive clusters with clear probabilistic structures. nonPeerReviewed
Los géneros discursivos y las secuencias didácticas: el lugar de los ejemplos prototípicos en la enseñanza y aprendizaje de la escritura
2018
[EN] From a social perspective, the aim of writing teaching is for students to be able to understand and write a great diversity of discursive genres, allowing them to behave as reflexive and critical citizens in different social spheres. In the process of mastery of each genre, the mental representation of the text is key, which acts as a regulating element of writing in different phases. This article shows the difficulties of the students to appropriate a specific genre (a book review), based on the data of a classroom research with students of 3rd ESO that addresses the writing of reviews through a didactic sequence including, as a regulatory element, prototypical examples of the genre. …
Discursive genres and didactic sequences: The place of the prototypical examples in the teaching and learning of writing
2018
[EN] From a social perspective, the aim of writing teaching is for students to be able to understand and write a great diversity of discursive genres, allowing them to behave as reflexive and critical citizens in different social spheres. In the process of mastery of each genre, the mental representation of the text is key, which acts as a regulating element of writing in different phases. This article shows the difficulties of the students to appropriate a specific genre (a book review), based on the data of a classroom research with students of 3rd ESO that addresses the writing of reviews through a didactic sequence including, as a regulatory element, prototypical examples of the genre. …
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity Habits
2020
While the detrimental effects of a chronic positive energy balance due to a sedentary lifestyle have been well established, the impacts of a short period of abruptly reduced physical activity and overeating arising from strict confinement due to the COVID-19 pandemic will soon start to emerge. To reasonably anticipate major consequences according to the available evidence, we hereby review the literature for studies that have explored the health impacts of several weeks of a reduction in physical activity and daily step-count combined with modified eating habits. These studies identify as main metabolic consequences increases in insulin resistance, total body fat, abdominal fat and inflamma…