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showing 10 items of 6731 documents

Marine Isonitriles and Their Related Compounds.

2016

Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isoni…

ChinaisothiocyanatesMagnetic Resonance SpectroscopyStereochemistrycarbonimidic dichloridesmalariaPharmaceutical ScienceReviewBiology010402 general chemistry01 natural sciencesantibioticsStructure-Activity RelationshipDrug DiscoveryOrganic chemistryHumansSeawaterPharmacology Toxicology and Pharmaceutics (miscellaneous)lcsh:QH301-705.5isonitriles010405 organic chemistryTerpenesmarine natural productsformamides0104 chemical scienceslcsh:Biology (General)Marine drugs
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A comparative analysis between Finns and Chinese : how communication traits affect self-disclosure in intercultural friendships?

2016

Self-disclosure, or the process revealing personal information about oneself to another, plays a vital role in friendship formation and maintenance, and cultured self-disclosure has been proven to be a powerful factor influencing intercultural friendships. Substantial cross-cultural research has shown self-disclosure differs among different cultural groups, but little research has examined what factors facilitate or impede self-disclosure in intercultural friendships. This research answers this call from a communication traits perspective. The focus of this research is to compare similarities and differences between Finns and Chinese in dimensions of self-disclosure in intercultural friends…

Chineseystävyyskulttuurienvälinen vuorovaikutusself-disclosureWTCsuomalaisetintercultural friendshipcommunication traitskiinalaisetSPCCFinns
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Lichen microalgae are sensitive to environmental concentrations of atrazine

2017

The identification of new organisms for environmental toxicology bioassays is currently a priority, since these tools are strongly limited by the ecological relevance of taxa used to study global change. Lichens are sensitive bioindicators of air quality and their microalgae are an untapped source for new low-cost miniaturized bioassays with ecological importance. In order to increase the availability of a wider range of taxa for bioassays, the sensitivity of two symbiotic lichen microalgae, Asterochloris erici and Trebouxia sp. TR9, to atrazine was evaluated. To achieve this goal, axenic cultures of these phycobionts in suspension were exposed to a range of environmental concentrations of …

Chlorophyll0301 basic medicineTrebouxiaLichensPopulation010501 environmental sciencesBiologyEcotoxicology01 natural sciences03 medical and health scienceschemistry.chemical_compoundChlorophytaBotanyMicroalgaeEcotoxicologyAtrazineSymbiosiseducationAxenic0105 earth and related environmental scienceseducation.field_of_studyDose-Response Relationship DrugGeneral Medicinebiology.organism_classificationPollution030104 developmental biologychemistryEnvironmental toxicologyAtrazineEcotoxicityBioindicatorWater Pollutants ChemicalFood ScienceJournal of Environmental Science and Health, Part B
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Decreasing the chlorophyll a/b ratio in reconstituted LHCII: Structural and functional consequences

1999

Trimeric (bT) and monomeric (bM) light-harvesting complex II (LHCII) with a chlorophyll a/b ratio of 0.03 were reconstituted from the apoprotein overexpressed in Escherichia coli. Chlorophyll/xanthophyll and chlorophyll/protein ratios of bT complexes and 'native' LHCII are rather similar, namely, 0.28 vs 0. 27 and 10.5 +/- 1.5 vs 12, respectively, indicating the replacement of most chlorophyll a molecules with chlorophyll b, leaving one chlorophyll a per trimeric complex. The LD spectrum of the bT complexes strongly suggests that the chlorophyll b molecules adopt orientations similar to those of the chlorophylls a that they replace. The circular dichroism (CD) spectra of bM and bT complexes…

ChlorophyllChlorophyll bProtein FoldingChlorophyll aCircular dichroismPhotosynthetic Reaction Center Complex ProteinsLight-Harvesting Protein Complexesmedicine.disease_causeBiochemistryAbsorptionStructure-Activity Relationshipchemistry.chemical_compoundThermolysinmedicineEscherichia colichemistry.chemical_classificationPigmentationChlorophyll ACircular DichroismCrystallographySpectrometry FluorescenceMonomerEnergy TransferchemistrySpectrophotometryChlorophyllXanthophyllBiochemistry
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Boronic Acids of Pharmaceutical Importance Affect the Growth and Photosynthetic Apparatus of Cyanobacteria in a Dose-Dependent Manner

2020

The dynamic increase in the commercial application of antimicrobial derivatives of boronic acids, and potential impact of their presence in aquatic systems, supports the necessity to study the toxicity of these substances towards microorganisms of crucial meaning in the environment. One example of the mentioned derivatives is tavaborole (5-fluoro-substituted benzoxaborole), a pharmaceutical agent with antifungal activity. Cyanobacteria were used as model organisms, which are photoautotrophic prokaryotes, as representative aquatic bacteria and photoautotrophs associated with the plant kingdom. To the best of our knowledge, we investigated this issue for the first time. In order to recognize …

ChlorophyllCyanobacteriaHealth Toxicology and MutagenesisMicroorganismlcsh:Medicinebactericidal activitypharmaceuticalsToxicologyPhotosynthesisaryl boronic acids01 natural sciencescyanobacteriaArticle03 medical and health scienceschemistry.chemical_compoundFood sciencephotosynthetic pigmentsPhotosynthesisCarotenoidchemistry.chemical_classification0303 health sciencesDose-Response Relationship Drugbiology010405 organic chemistry030306 microbiologyChemistryPhycobiliproteinlcsh:RAntimicrobialbiology.organism_classificationBoronic AcidsHalophile0104 chemical sciencesChlorophyllToxins
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The toxicity of Roundup® 360 SL formulation and its main constituents: Glyphosate and isopropylamine towards non-target water photoautotrophs

2010

The toxicity of commercial formulation of Roundup® 360 SL, widely used, nonselective herbicide and its main constituents, glyphosate (PMG), equimolar (1:1) isopropylamine salt of glyphosate (GIPA) and isopropylamine (IPA) was examined towards eight aquatic microphotoautotrophs; seven cyanobacterial strains representing either saline or freshwater communities, and common eukaryotic algae Chlorella vulgaris Beijerinck. Autotrophs were cultured 21 days in their appropriate standard media supplemented with various amounts of Roundup®, glyphosate, GIPA and IPA. The determination of the growth of examined photoautotrophs was performed by time-course measurements of total chlorophyll content in ex…

ChlorophyllCyanobacteriaHealth Toxicology and MutagenesisRoundup®GlycineCyanobacteriachemistry.chemical_compoundglyphosateAquatic plantToxicity TestsBotanyIsopropylamineFood scienceAutotrophChromatography High Pressure LiquidalgaeAnalysis of VarianceDose-Response Relationship DrugPropylaminesbiologyisopropylamineHerbicidesPublic Health Environmental and Occupational HealthtoxicityGeneral Medicinebiology.organism_classificationSaline waterPollutionchemistryGlyphosateChlorophyllToxicityLinear ModelsChlorella vulgarisWater Pollutants ChemicalEcotoxicology and Environmental Safety
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Semiempirical PM5 molecular orbital study on chlorophylls and bacteriochlorophylls: Comparison of semiempirical,ab initio, and density functional res…

2003

The semiempirical PM5 method has been used to calculate fully optimized structures of magnesium-bacteriochlorin, magnesium-chlorin, magnesium-porphin, mesochlorophyll a, chlorophylls a, b, c(1), c(2), c(3), and d, and bacteriochlorophylls a, b, c, d, e, f, g, and h with all homologous structures. Hartree-Fock/6-31G* ab initio and density functional B3LYP/6-31G* methods were used to optimize structures of methyl chlorophyllide a, chlorophyll c(1), and methyl bacteriochlorophyllides a and c for comparison. Spectroscopic transition energies of the chromophores and their 1:1 or 1:2 solvent complexes were calculated with the Zindo/S CIS method. The self-consistent reaction field model was used t…

ChlorophyllModels MolecularAb initioGeneral ChemistryPorphyrinStructure-Activity RelationshipComputational Mathematicschemistry.chemical_compoundchemistryAbsorption bandComputational chemistryAtomPhysical chemistryMoleculeMagnesiumZINDOMolecular orbitalBacteriochlorophyllBacteriochlorophyllsJournal of Computational Chemistry
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Quantitative structure-retention and retention-activity relationships of beta-blocking agents by micellar liquid chromatography.

2001

Abstract Sixteen β-blocking agents (acebutolol, alprenolol, atenolol, bisoprolol, carteolol, celiprolol, esmolol, labetalol, metoprolol, nadolol, oxprenolol, pindolol, practolol, propranolol, sotalol and timolol) showing a large range of hydrophobicity (octanol–water partition coefficients, log P between −0.026 and 2.81) were subjected to micellar liquid chromatography with sodium dodecyl sulfate as micelle forming agent, and n-propanol as organic modifier. The correlation between log P and the retention factor extrapolated to a mobile phase free of micelles and organic modifier was investigated. The use of an interpolated retention factor or the retention factor for specific individual exp…

ChromatographyChemistryOrganic ChemistryAdrenergic beta-AntagonistsQuantitative Structure-Activity RelationshipGeneral MedicineBiochemistryMicelleAcebutololMicellar electrokinetic chromatographyAnalytical ChemistryPartition coefficientchemistry.chemical_compoundMicellar liquid chromatographyOxprenololmedicineAlprenololSodium dodecyl sulfateMicellescirculatory and respiratory physiologymedicine.drugChromatography LiquidJournal of chromatography. A
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Development of predictive retention-activity relationship models of non-steroidal anti-inflammatory drugs by micellar liquid chromatography: comparis…

2000

The predictive and interpretative capability of quantitative chromatographic retention-biological activity models is supported by the fact that under adequate experimental conditions the solute partitioning into chromatographic system can emulate the solute partitioning into lipid bilayers of biological membranes, which is the basis for drug and metabolite uptake, passive transport across membranes and bioaccumulation. The use of micellar solutions of Brij35 as mobile phases in reversed-phase liquid chromatography has proven to be valid to predict some biological activities of different kinds of drugs. In this study, quantitative retention-activity relationship (QRAR) models to describe som…

ChromatographyPassive transportMetaboliteAnti-Inflammatory Agents Non-SteroidalSynthetic membraneBiological membraneMembranes ArtificialGeneral Chemistrychemistry.chemical_compoundStructure-Activity RelationshipMembranechemistryMicellar liquid chromatographyPredictive Value of TestsMicellar solutionsLipid bilayerChromatography LiquidJournal of chromatography. B, Biomedical sciences and applications
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Notes on the karyology, genetics and ecology of Genista sect. Voglera in Sicily

2012

To investigate the biosystematic and genetic relationships among Sicilian species of Genista sect. Voglera, four populations of three species, Genista aristata C. Presl, Genista cupanii Guss., and Genista madoniensis Raimondo, have been studied. Genista madoniensis is tetraploid, with a chromosome number of 2n = 48, as are the other two species. An isozyme study showed that G. madoniensis is taxonomically closer to G. aristata than to G. cupanii, the latter possessing four unique alleles. The results are discussed in the context of the ecological characteristics of each species.

Chromosome numberbiologyEcologyEcology (disciplines)Settore BIO/02 - Botanica SistematicaZoologyMediterranean region Sicilian endemism chromosome number genetic and ecological relationships Genista sect. Voglera G. madoniensisKaryotypeContext (language use)Plant ScienceGenistabiology.organism_classificationSectlanguage.human_languageBotanyGenista aristatalanguageSicilianEcology Evolution Behavior and Systematics
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