6533b857fe1ef96bd12b4745

RESEARCH PRODUCT

Boronic Acids of Pharmaceutical Importance Affect the Growth and Photosynthetic Apparatus of Cyanobacteria in a Dose-Dependent Manner

Jacek LipokAgnieszka Adamczyk-woźniakEmilia NiemczykJerzy Pogrzeba

subject

ChlorophyllCyanobacteriaHealth Toxicology and MutagenesisMicroorganismlcsh:Medicinebactericidal activitypharmaceuticalsToxicologyPhotosynthesisaryl boronic acids01 natural sciencescyanobacteriaArticle03 medical and health scienceschemistry.chemical_compoundFood sciencephotosynthetic pigmentsPhotosynthesisCarotenoidchemistry.chemical_classification0303 health sciencesDose-Response Relationship Drugbiology010405 organic chemistry030306 microbiologyChemistryPhycobiliproteinlcsh:RAntimicrobialbiology.organism_classificationBoronic AcidsHalophile0104 chemical sciencesChlorophyll

description

The dynamic increase in the commercial application of antimicrobial derivatives of boronic acids, and potential impact of their presence in aquatic systems, supports the necessity to study the toxicity of these substances towards microorganisms of crucial meaning in the environment. One example of the mentioned derivatives is tavaborole (5-fluoro-substituted benzoxaborole), a pharmaceutical agent with antifungal activity. Cyanobacteria were used as model organisms, which are photoautotrophic prokaryotes, as representative aquatic bacteria and photoautotrophs associated with the plant kingdom. To the best of our knowledge, we investigated this issue for the first time. In order to recognize the under-stress response of those microorganisms, the concentration of photopigments&mdash

yearjournalcountryeditionlanguage
2020-12-13Toxins
10.3390/toxins12120793http://dx.doi.org/10.3390/toxins12120793