Search results for "ship"
showing 10 items of 6731 documents
Evidence for the presence of P2y and P2x receptors with different functions in mouse stomach.
2005
To clarify the function of P2 receptor subtypes in mouse stomach, the motor responses to ATP, alpha,beta-methyleneATP (alpha,beta-MeATP), P2X receptor agonist, 2-methylthioATP (2-MeSATP), P2Y receptor agonist, and the effects of the desensitisation of P2X receptors with alpha,beta-MeATP and of P2Y receptors with ADPbetaS were analysed recording the endoluminal pressure from whole-organ. ATP-induced relaxation was antagonised by suramin, non-selective P2 receptor antagonist, by desensitisation of P2Y receptors with ADPbetaS, and increased by desensitisation of P2X receptors with alpha,beta-MeATP. alpha,beta-MeATP produced biphasic responses: relaxation, reduced by P2X- or P2Y desensitisation…
Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms
1994
Twenty schizophrenic inpatients with either predominantly positive or predominantly negative symptoms were treated with the dopamine autoreceptor agonist roxindole in prospective open clinical trials. There was no antipsychotic effect in the subgroup with positive symptoms, whereas the subgroup with negative symptoms, especially those with the residual type of schizophrenia, showed a moderate but significant 20% reduction in total scores on the Scale for the Assessment of Negative Symptoms.
Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity
2011
Background The hippocampus and its 5-hydroxytryptamine transmission plays an important role in depression related to its involvement in limbic circuit plasticity. Methods The analysis was made with bioluminescence resonance energy transfer, co-immunoprecipitation, in situ proximity ligation assay, binding assay, in cell western and the forced swim test. Results Using bioluminescence resonance energy transfer analysis, fibroblast growth factor receptor 1 (FGFR1)-5-hydroxytryptamine 1A (5-HT1A) receptor complexes have been demonstrated and their specificity and agonist modulation characterized. Their presence based on co-immunoprecipitation and proximity ligation assay has also been indicated…
Biogenic Amines Modulate Olfactory Receptor Neurons Firing Activity in Mamestra brassicae
2001
The modulatory effects of the biogenic amines octopamine and serotonin on pheromonal receptor neurons of Mamestra brassicae were investigated. The responses to sex pheromone components of two cells types (A and B) in single male long sensilla trichodea were monitored. Cell types A and B do not respond to the same compound. The response of type A to a pulse of the major sex pheromone component increased 5 min after octopamine injection. Responses of type B to other odorants increased after 30 min. In the absence of any pheromone stimulation the background firing activity of type A increased following octopamine injection. This background activity was used to evaluate the kinetics of octopami…
α7 Nicotinic acetylcholine receptors and modulation of gabaergic synaptic transmission in the hippocampus
2000
The present report provides new findings regarding modulation of gamma-aminobutyric acid (GABA) transmission by alpha7 nicotinic receptor activity in CA1 interneurons of rat hippocampal slices. Recordings were obtained from tight-seal cell-attached patches of the CA1 interneurons, and agonists were delivered to the neurons via a modified U-tube. Application for 6 s of the alpha7 nicotinic receptor-selective agonist choline (or =1 mM) to all CA1 interneurons tested triggered action potentials that were detected as fast current transients. The activity triggered by choline terminated well before the end of the agonist pulse, was blocked by the alpha7 nicotinic receptor antagonist methyllycaco…
Ontogenetic and Pharmacological Studies on Metabotropic Glutamate Receptors Coupled to Phospholipase D Activation
1997
The present study was aimed at characterizing the metabotropic receptor subtype which is involved in the activation of phospholipase D (PLD) by glutamate in rat hippocampal slices. We first observed that the ontogenetic profile of glutamate-induced hydrolysis of phosphoinositides and of phosphatidylcholine was strikingly similar. Both pathways were significantly activated by glutamate in tissue taken from 3-, 8- and 15-day old rats, but not in adult rats. PLD activation was strongest in slices taken from 8-day old rats. At this age, quisqualate had a higher potency for PLD activation (EC50: 0.6 microM) than 1S,3R-ACPD (EC50: 16 microM) and DHPG, a specific activator of group I mGluR, was a …
Humane Orientation as a New Cultural Dimension of the GLOBE Project: A Validation Study of the GLOBE Scale and Out-Group Humane Orientation in 25 Cou…
2013
SCHLÖSSER, Oliver; HEINTZE, Anna-Maria; AL-NAJJAR, Musaed; ARCISZEWSKI, Thomas; BESEVEGIS, Elias; BISHOP, George David; BONNES, Mirilia; CLEGG, Chris W.; DROZDA-SENKOWSKA, Ewa; GABORIT, Mauricio; GARZON, Dayra; HANSEN, Tia G. B.; HESZEN, Irena; JUHASZ, Marta; KEATING, Mary A.; MANGUNDJAYA, Wustari; MANSOR, Norma; MITCHELSON, Jacqueline K.; ORTIZ-REYNOSO, Alejandra; PANDEY, Janak; PAVAKANUN, Ubolwanna; PAVLOPOULOS, Vassilis; PEIRO, Jose M.; POTOCNIK, Kristina; RESTREPO-ESPINOSA, Maria H.; SEMMER, Norbert; TUPINAMBA, Antonio Caubi Ribeiro; VENTURA, Elizabeth R.; WHOOLERY, Matthew; ZHANG, Kan. Humane orientation as a new cultural dimension of the globe project: a validation study of the globe …
Closeness to Parents and Experiencing Threats with COVID-19 Mediates the Link between Personality and Stress among Adolescents
2021
Purpose: many researchers have already established that the 2019 COVID-19 pandemic poses a threat to adolescent psychological health. Studies on the COVID-19 pandemic mainly focus on individual psychological consequences, such as anxiety, depression or stress. The presented study added a family context to psychological analyses of the COVID-19 pandemic in adolescence. We examined the mediational effects of closeness to parents and perceived pandemic-related threats to relationships between personality (emotional stability and agreeableness) and stress in adolescents. Methods: in total, 413 students from secondary schools in southern Poland completed questionnaires measuring stress, personal…
Associations between personality, sports participation and athletic success. A comparison of Big Five in sporting and non-sporting adults
2018
Abstract The present study investigates whether the Big Five personality traits are different among diverse sports populations. A sample of 881 male athletes and non-athletes completed a self-report questionnaire measuring their personality traits. The Exploratory Structure Equation Modeling (ESEM) approach is adopted to test measurement invariance and mean differences among groups. The results indicate that athletes who had experienced the most success in their sport scored higher than non-athletes in each personality dimension of the Big Five, with the exception of openness, while less successful athletes scored higher than non-athletes only in extraversion and agreeableness. The more suc…
Determinants of Italian agri-food exports in non-EU Mediterranean Partner Countries: An empirical investigation through a gravity model approach
2013
The aim of this paper is to lay emphasis on the main factors (economic, historical, structural, etc.) that affect Italian agri-food exports in the non-EU Mediterranean Partner Countries (MPCs). The authors estimate a gravity equation including some of the main variables found in the reference literature useful to highlight the main factors which influence the bilateral exchanges. The results show that the variables traditionally included in the gravity equation present the expected sign. In particular, Italian agri-food exports towards its neighbouring Mediterranean countries are positively affected by income of partner countries, colonial and historical ties, geographical proximity and the…