Search results for "simulation"
showing 10 items of 5095 documents
BDI Modelling and Simulation of Human Behaviours in Bushfires
2016
Each summer in Australia, bushfires burn many hectares of forest, causing deaths, injuries, and destruction of property. Emergency management strategies rely on expected citizens’ behaviour which differs from reality. In order to raise their awareness about the real population behaviour, we want to provide them with a realistic agent-based simulation. The philosophically-grounded BDI architecture provides a very suitable approach but is little used due to the lack of adapted tools. This paper uses this case study to illustrate two new tools to fill this gap: the Tactics Development Framework (TDF) and GAMA BDI architecture.
The inside out forehand as a tactical pattern in men’s professional tennis
2017
AbstractThe so-called inside out forehand has an active role in the baseline strategy because it offers the players new possibilities of hitting the incoming ball with their preferred shot by covering their weaker side and, at the same time, playing the ball with more open angles and directions which create more aggressive patterns of play. The purpose of this study is to analyse the use of this shot as well as its incidence on the men’s professional game both, right- and left-handed players. Eighteen matches corresponding to Grand Slam and ATP finals played between 2011 and 2014 were analysed. Eleven players (men) with ATP rankings between 1 and 14 were studied. Data show that the inside o…
Nursing Students Managing Deteriorating Patients: A Systematic Review and Meta-Analysis
2018
Abstract Background The objective was to summarize knowledge and systematically collect and quantify meta-analytical results regarding the effects of high-fidelity simulation in nursing education to improve students' ability to recognize and respond to deteriorating patients. Methods In total, 4048 citations were screened, 40 articles were selected for full-text screening, and 14 articles were included. Six articles were subsequently included in the meta-analysis. Results Knowledge and performance increased after simulation. Four studies reported an increase in self-confidence. Conclusion Findings support that studies with high-quality research designs and improved measurement practices are…
Including the Past: Performance Modeling Using a Preload Concept by Means of the Fitness-Fatigue Model
2019
Abstract In mathematical modeling by means of performance models, the Fitness-Fatigue Model (FF-Model) is a common approach in sport and exercise science to study the training performance relationship. The FF-Model uses an initial basic level of performance and two antagonistic terms (for fitness and fatigue). By model calibration, parameters are adapted to the subject’s individual physical response to training load. Although the simulation of the recorded training data in most cases shows useful results when the model is calibrated and all parameters are adjusted, this method has two major difficulties. First, a fitted value as basic performance will usually be too high. Second, without mo…
Testing of wireless sensor performance in Vessel-to-Vessel Motion Compensation
2016
Relative Vessel-to-Vessel Motion Compensation (VVMC) between two floating vessels can be considered an extension of existing Active Heave Compensation (AHC), which is current state-of-the-art in the offshore industry. In this paper, the experimental results from a small-scale experimental setup of a VVMC scenario are presented. The work focuses on the kinematics related to VVMC, sensor accuracy of Motion Reference Units (MRUs), and the communication delay related to wireless transmission of MRU data between two floating vessels. The accuracies of the MRU sensors are good and verified to be less than 5% of the heave amplitude. The wireless communication link had a typical time-delay of 8ms. …
Visualization of Simulated Arrhythmias due to Gap Junctions
2018
New computational models are able to simulate details of cardiac cell networks. Their results allow a better understanding of the functionality of the heart and suggest possible actions to reduce non-fatal premature beats that can give rise to serious diseases. We developed a user-friendly interface to organize Neuron simulations and to present in real-time a three-dimensional representation of the electrical activity due to the gap junctions which interconnect the cells inside cardiac tissues. All physiological parameters were set according to real experimental observations and compared against different types of arrhythmias, retrieved from the Physionet Data Base.
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods
2017
Background: Isoindolo[2,1-alpha] quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell lines and topoisomerase I inhibitors. In particular, their water soluble imine or iminium salts recently synthesized showed potent growth inhibitory effect on NCI-60 tumor cell line panel and biological studies performed on the most active compounds demonstrated that they cause DNA damage via topoisomerase I poisoning. Objective: Herein, we investigate with molecular modeling methods, the common features responsible for topoisomerase I inhibition of the water-soluble isoindolo[2,1-alpha] quinoxalin-6-imines, by compa…
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
2016
International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance.
2018
Abstract Background Epimagnolin A is an ingredient of the Chinese crude drug Shin-i, derived from the dried flower buds of Magnolia fargesii and Magnolia flos, which has been traditionally used for the treatment of allergic rhinitis and nasal congestion, empyema, and sinusitis. The pharmacokinetic activity of epimagnolin A remains to be evaluated. Purpose In this study, we examined the possible interactions of epimagnolin A with human ATP-binding cassette (ABC) transporter ABCB1, a membrane protein vital in regulating the pharmacokinetics of drugs and xenobiotics. Study design/methods The interaction of epimagnolin A with ABCB1 was evaluated in calcein, ATPase, and MTT assays by using Flp-I…
Cytotoxicity of sesquiterpene alkaloids from Nuphar plants toward sensitive and drug-resistant cell lines.
2018
Multi-drug resistance (MDR) is a critical problem in cancer chemotherapy. MDR causes the overexpression of ATP-binding cassette (ABC) transporters and mutations in tumor suppressor genes and oncogenes. To tackle this issue, in this study, we focused on Nuphar plants, which have been traditionally used as food. Sesquiterpene alkaloids (1–3) were isolated from N. japonicum and dimeric sesquiterpene thioalkaloids (4–10) were isolated from N. pumilum. P-glycoprotein-overexpressing CEM/ADR5000 cells were cross-resistant to 6,6′-dihydroxythiobinupharidine (10). Using in silico molecular docking, we calculated the binding energies and simulated the interactions of these compounds with the correspo…