Search results for "slip"
showing 10 items of 471 documents
Worldwide burden of LDL cholesterol: Implications in cardiovascular disease
2020
Abstract Background and aim an increased value of low-density lipoprotein cholesterol (LDL-C) is now universally considered a major cardiovascular disease (CVD) risk factor. LDL-C is included in the vast majority of worldwide cardiovascular risk prediction algorithms, as well as in the guidelines for cardiovascular risk prevention. We aimed to provide an overview of the worldwide adverse healthcare impact of low-density lipoprotein cholesterol (LDL-C). Methods and results Data on the epidemiologic burden of LDL-C >1.3 mmol/L were retrieved from Global Health Data Exchange (GHDx) registry. The current burden is 94.92 million disability-adjusted life years (DALYs), with an exponential increas…
Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation
2012
The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS-associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. De novo MetS affected 32.9% of our cohort (n = 170) within 2 years after OLT. Multivariate analysis identified glycosylated hemoglobin (HbA1c) levels ≥5% [odds ratio (OR) = 3.5; 95% confidence interval (CI) = 1.56-8.13, P = 0.003], diabetes mellitus (OR = 4.31, CI = 1.69-10.99, P = 0.002), and arterial hypertension (OR = 4.59, CI = 1.46-14.49, P = 0.009) as independent risk factors for de novo MetS. MetS incidence correlated with steroid do…
Controlling Diabetes After Liver Transplantation: Room for Improvement.
2016
BACKGROUND Diabetes mellitus is a chronic illness with great impact on long-term outcome after liver transplantation (LT). Despite this, the current level of glycemic control and quality of screening strategies for diabetes-associated conditions that are being provided to liver transplant recipients with diabetes have not yet been assessed. METHODS We performed a cross-sectional, multicenter study that included 344 liver transplant recipients and examined the level of glycemic control and its associated factors, as well as the quality of screening strategies for diabetes-associated conditions. RESULTS Seventy-five patients (21.8%) suffered from diabetes before transplantation, and 82 (23.8%…
A ride comfort tyre model for off-highway vehicles
2014
Tyre modelling is a major challenge when using time domain multibody simulation models to evaluate ride comfort on off-highway commercial vehicles. Further, parameters for these big tyres are difficult to obtain and thus, commercial car tyre models are difficult to apply. In this research work, a simple vertical tyre model for off-highway ride comfort evaluation is suggested. A displaced volume approach has been developed and combined with the slip theory to yield a tyre model that can be characterised by only three parameters. Full scale measurements on a dump truck have been carried out. Force responses from measurements are compared to the simulation results. Acceleration responses and t…
The southern Tyrrhenian Sea margin an example of lithospheric scale strike-slip duplex
2010
The southern Tyrrhenian Sea margin is dominated by deformations whose kinematics are relatively poorly constrained, and different models have been proposed to account for its recent evolution. Analysis of new structural and space geodesy data, combined with available geophysical information, reveal a deformation field characterised by subhorizontal NW-SE directed shortening and SW-NE directed extension. The main recognised regional-scale structure comprises E-W trending fault zones, namely the Ustica-Eolie Line and the Mt. Kumeta-Alcantara Line, connected by the NW-SE trending Marettimo, Trapani, San Vito, Palermo, Gratteri-Mt. Mufara and Eolie faults. This fault network displays a remarkab…
Lower Crustal Rheology Controls the Development of Large Offset Strike‐Slip Faults During the Himalayan‐Tibetan Orogeny
2020
International audience
Liraglutide reduces postprandial hyperlipidaemia by increasing apoB48 catabolism and by reducing apoB48 production
2016
IF 6.080; International audience
New insights into the pharmacology of the short-chain free fatty acid receptors 2 and 3
2011
Metabolic diseases, such as diabetes, dyslipidemia or obesity, are more and more weighing on public health expenses in developed countries. Despite active research, these widespread diseases remain difficult to handle. Promising new therapeutic strategies against metabolic diseases include the development of drugs targeting the free fatty acid receptors, as key players in metabolism homeostasis. In this context, the current PhD thesis focuses on the study of two G protein-coupled receptors, namely the short-chain free fatty acid receptors 2 (FFA2) and 3 (FFA3). First, we investigated the expression of the two receptors of interest in a variety of cell types. Then, in order to study the phar…
Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Pat…
2018
: Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke, which are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications.
Dislipidēmijas saistība ar aknu cirozes komplikācijām un klīniskajiem iznākumiem
2020
Dislipidēmija un aptaukošanās ir būtiska vairāku slimību ietekmējoša riska faktoru kombinācija, kam sabiedrībā ne vienmēr tiek pievērsta pietiekami liela uzmanība. Dislipidēmija tiek saistīta ar paaugstinātu kardiovaskulāro risku, 2. tipa cukura diabētu (CD) un nealkohola steatohepatīta (NASH) attīstību. NASH ir hroniska aknu slimība, kas var progresēt aknu cirozē. Tā kā aknas ir galvenais holesterīna un citu lipīdu avots organismā, tad pētījuma mērķis ir noskaidrot dislipidēmijas izplatību aknu cirozes pacientu vidū un tās saistību ar blakusslimībām, kā arī izmaiņām aknu beigu stadijas modelī (MELD) un Child-Pugh prognostiskajos rezultātos. Retrospektīvs pētījums tika veikts Paula Stradiņa…