Search results for "soin"
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Tandem Nucleophilic Addition−Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines
2010
A highly stereoselective synthesis of fluorinated 1,3-disubstituted isoindolines is described. To this end, a tandem reaction consisting of a diastereoselective addition of fluorinated nucleophiles to Ellman's N-(tert-butanesulfinyl)imines followed by an intramolecular aza-Michael reaction has been developed. This strategy allows for the construction of isoindolines bearing several degrees of fluorination (mono-, di-, or trifluoromethyl as well as heavier fluorinated groups). In the majority of all cases, the products are formed as single isomers.
Improved AMYR program: an algorithm for the theoretical simulation of molecular associations, including geometrical and topological characterization …
1991
Program AMYR, originally written by S. Fraga (University of Alberta, Canada), allows for the calculation of molecular associations using a pair-wise atom-atom potential. The interaction energy is evaluated through a 1/R expansion. Our improved version includes a dispersion energy term in the potential corrected by damping functions, the possibility of carrying out energy minimizations through variable metric methods, as well as the optional calculation of geometrical and topological indices. Program AMYR has been adapted also for high-performance computing and vectorization. An interactive version of the program carries out real-time molecular graphics showing simultaneously the energy prof…
Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors
2021
A series of [1,3]thiazolo[4,5-e]isoindoles has been synthesized through a versatile and high yielding multistep sequence. Evaluation of the antiproliferative activity of the new compounds on the full NCI human tumor cell line panel highlighted several compounds that are able to inhibit tumor cell proliferation at micromolar-submicromolar concentrations. The most active derivative 11g was found to cause cell cycle arrest at the G2/M phase and induce apoptosis in HeLa cells, following the mitochondrial pathway, making it a lead compound for the discovery of new antimitotic drugs.
Subphthalocyanines: addressing water-solubility, nano-encapsulation, and activation for optical imaging of B16 melanoma cells
2014
Water-soluble disulfonato-subphthalocyanines (SubPcs) or hydrophobic nano-encapsulated SubPcs are efficient probes for the fluorescence imaging of cells. 20 nm large liposomes (TEM and DLS) incorporated about 13% SubPc. Moreover, some of these fluorophores were found to be pH activatable.
Magneto-optical nanomaterials: a SPIO–phthalocyanine scaffold built step-by-step towards bimodal imaging
2013
A SPIO-phthalocyanine nanohybrid is developed as a bimodal contrast agent for Optical and Magnetic Resonance Imaging. The organic coating was covalently attached onto SPIO in a step-by-step approach. Each coated-SPIO was thoroughly characterized. The hydrodynamic size of the SPIO-Pc is ca. 60 nm with a coverage of ca. 690 Pc/SPIO.
Interactions of zinc octacarboxyphthalocyanine with selected amino acids and with albumin
2015
Effect of selected amino acids (glycine, l-histidine, l-cysteine, l-serine, l-tryptophan) and albumin on the spectroscopic properties and photostability of zinc octacarboxyphthalocyanine (ZnPcOC) was explored in the phosphate buffer at a pH of 7.0. The photodegradation of ZnPcOC alone and in the presence of amino acids or albumin has been investigated in aqueous phase using UV-366 nm and daylight irradiation. Kinetic analysis showed that the interaction with amino acids or albumin enhances the photostability of ZnPcOC. To answer the question of how zinc phthalocyanine interacts with amino acids extensive DFT calculations were performed. Analysis of the optimized geometry features of ZnPcOC:…
Vuorovaikutus osana opettajan arviointiosaamista (VOPA) -toimintamallin vaiheittaiset kuvaukset
2021
Vuorovaikutus osana opettajan arviointiosaamista (VOPA) -toimintamallin vaiheittaiset kuvaukset edesauttavat opetustilanteisiin liittyvän vuorovaikutuksen systemaattista havainnointia ja reflektointia sekä tarjoavat yhteistä sanastoa teeman käsittelyyn. Tarkastelemalla ryhmän vuorovaikutusta eri vaiheiden kautta, tuetaan ajatusta opettajan vuorovaikutusosaamisen kehittyvästä luonteesta. Opettajaopiskelijat ja opettajat voivat hyödyntää vaiheittaisia kuvauksia oman opetuksensa suunnittelussa, toteutuksessa ja reflektoinnissa. Opettajankouluttajat voivat hyödyntää vaiheittaisia kuvauksia opiskelijoiden opetusharjoittelun tutkimusperustaisessa havainnoinnissa ja ohjaamisessa. Learning interact…
Vous avez dit mandragore ? Une médecine médiévale, catalogue d'exposition Musée de Saint-Antoine-l’Abbaye – à l’occasion de l’exposition Vous avez di…
2018
Les concepts de base et les méthodes de prévision des besoins en main-d'oeuvre qualifiée : le cas français
1982
Ce document a été préparé pour les participants à un projet de recherche et à un atelier sur "L'Evaluation Rétrospective des Méthodes de prévision pour les Besoins en Main-d'Oeuvre Qualifiée" qui aura lieu à Paris, IIPE: 6-7 Septembre 1982 (UNESCO).