Search results for "solution"
showing 10 items of 5638 documents
Physicochemical compatibility and stability of nebulizable drug admixtures containing Dornase alfa and tobramycin.
2012
The objective of this in-vitro study was to determine whether admixtures of the inhalation solutions Pulmozyme(®) (Dornase alfa) and either Bramitob(®) or Tobi(®) (both containing Tobramycin) are physicochemically compatible and to analyze the aerodynamic parameters of these admixtures. After mixing, test solutions were stored at room temperature and under ambient light conditions over a period of 24 h. Tobramycin concentrations were determined by using a fluorescence immunoassay. Stability of dornase alfa was determined by size-exclusion high performance liquid chromatography, ultraviolet spectroscopy, sodium dodecyl sulfate polyacrylamide gel electrophoresis and tentacle strong cation-exc…
Induction of stress proteins in human endothelial cells by heavy metal ions and heat shock.
1999
In the present study, we compared the induction of heat shock proteins (HSPs) by heat and heavy metal ions in three different endothelial cell types, namely, human umbilical vein endothelial cells, human pulmonary microvascular endothelial cells, and the cell line EA.hy 926. Our results show that especially Zn2+and Cd2+are inducers of 70-kDa (HSP70), 60-kDa (HSP60), 32-kDa (HSP32), and 27-kDa (HSP27) HSPs. The strength of inducibility is specific for each HSP. Ni2+and Co2+only show an inducible effect at very high concentrations, that is, in the clearly cytotoxic range. Furthermore, we investigated the time course of HSP expression and the involvement of heat shock factor-1. Our study demon…
Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?
2015
Inhalation is the preferred route of drug administration in chronic respiratory diseases because it optimises delivery of the active compounds to the targeted site and minimises side effects from systemic distribution. The choice of a device should be made after careful evaluation of the patient's clinical condition (degree of airway obstruction, comorbidities), as well as their ability to coordinate the inhalation manoeuvre and to generate sufficient inspiratory flow. These patient factors must be aligned with the specific advantages and limitations of each inhaler when making this important choice. Finally, adherence to treatment is not the responsibility of the patient alone, but should …
The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
2021
Abstract Background The SARS-CoV-2 pandemic has changed the health-care systems around the world in a remarkable way. We describe the strategies adopted to cope with the limitations imposed by the pandemic to the access to health care by patients diagnosed with idiopathic Pulmonary Fibrosis (IPF). Material and methods We conducted a retrospective observational analysis including IPF patients under antifibrotic drugs (nintedanib and pirfenidone) that accessed to the Outpatient clinic of the University of Palermo, Italy. Patients received a phone number and an email address in case of any urgency and a virtual meeting was settled up monthly. Results 40 patients (M/F: 30/10) were followed up, …
A closer look at mirrors and quotients of Calabi-Yau threefolds
2016
Let X be the toric variety (P1)4 associated with its four-dimensional polytope 1. Denote by X˜ the resolution of the singular Fano variety Xo associated with the dual polytope 1o. Generically, anticanonical sections Y of X and anticanonical sections Y˜ of X˜ are mirror partners in the sense of Batyrev. Our main result is the following: the Hodge-theoretic mirror of the quotient Z associated to a maximal admissible pair (Y, G) in X is not a quotient Z˜ associated to an admissible pair in X˜ . Nevertheless, it is possible to construct a mirror orbifold for Z by means of a quotient of a suitable Y˜. Its crepant resolution is a Calabi-Yau threefold with Hodge numbers (8, 4). Instead, if we star…
Parameter dependence for the positive solutions of nonlinear, nonhomogeneous Robin problems
2020
We consider a parametric nonlinear Robin problem driven by a nonlinear nonhomogeneous differential operator plus an indefinite potential. The reaction term is $$(p-1)$$-superlinear but need not satisfy the usual Ambrosetti–Rabinowitz condition. We look for positive solutions and prove a bifurcation-type result for the set of positive solutions as the parameter $$\lambda >0$$ varies. Also we prove the existence of a minimal positive solution $$u_\lambda ^*$$ and determine the monotonicity and continuity properties of the map $$\lambda \rightarrow u_\lambda ^*$$.
A note on homoclinic solutions of (p,q)-Laplacian difference equations
2019
We prove the existence of at least two positive homoclinic solutions for a discrete boundary value problem of equations driven by the (p,q) -Laplace operator. The properties of the nonlinearity ensure that the energy functional, corresponding to the problem, satisfies a mountain pass geometry and a Palais–Smale compactness condition.
La singularité de O’Grady
2006
Let M 2 v M_{2v} be the moduli space of semistable sheaves with Mukai vector 2 v 2v on an abelian or K 3 K3 surface where v v is primitive such that ⟨ v , v ⟩ = 2 \langle v,v \rangle =2 . We show that the blow-up of the reduced singular locus of M 2 v M_{2v} provides a symplectic resolution of singularities. This provides a direct description of O’Grady’s resolutions of M K 3 ( 2 , 0 , 4 ) M_{K3}(2,0,4) and M A b ( 2 , 0 , 2 ) M_{Ab}(2,0,2) . Résumé. Soit M 2 v M_{2v} l’espace de modules des faisceaux semi-stables de vecteur de Mukai 2 v 2v sur une surface K 3 K3 ou abélienne où v v est primitif tel que ⟨ v , v ⟩ = 2 \langle v,v \rangle =2 . Nous montrons que l’éclatement de M 2 v M_{2v} le…
Symmetry for positive critical points of Caffarelli–Kohn–Nirenberg inequalities
2022
Abstract We consider positive critical points of Caffarelli–Kohn–Nirenberg inequalities and prove a Liouville type result which allows us to give a complete classification of the solutions in a certain range of parameters, providing a symmetry result for positive solutions. The governing operator is a weighted p -Laplace operator, which we consider for a general p ∈ ( 1 , d ) . For p = 2 , the symmetry breaking region for extremals of Caffarelli–Kohn–Nirenberg inequalities was completely characterized in Dolbeault et al. (2016). Our results extend this result to a general p and are optimal in some cases.
Nonlinear vector Duffing inclusions with no growth restriction on the orientor field
2019
We consider nonlinear multivalued Dirichlet Duffing systems. We do not impose any growth condition on the multivalued perturbation. Using tools from the theory of nonlinear operators of monotone type, we prove existence theorems for the convex and the nonconvex problems. Also we show the existence of extremal trajectories and show that such solutions are $C_0^1(T,\mathbb{R}^N)$-dense in the solution set of the convex problem (strong relaxation theorem).