Search results for "starvation"

Could starvation minimize chemotherapy-induced toxicities?

2008

Background: In their recent paper Raffaghello, et al. examined the use of short-term starvation (STS) to induce differential stress resistance (DSR), that is increased protection of normal over cancer cells against chemotherapy-induced oxidative stress, using a range of model organisms. Objective/methods: We examine the results of this study and their significance. Results/conclusions: Raffaghello, et al. obtained evidence that STS induced DSR in yeast, mammalian cell cultures, and mice. It is possible that calorie restriction extends lifespan and prevents chronic diseases like tumors, by braking proliferation. We think that molecular mechanisms determining STS-induced DFS in mammals should…

Arabidopsis copper transport protein COPT2 participates in the crosstalk between iron deficiency responses and low phosphate signaling

2013

[EN] Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes, including respiration, photosynthesis, and oxidative stress protection. In many eukaryotic organisms, including yeast (Saccharomyces cerevisiae) and mammals, copper and iron homeostases are highly interconnected; yet, such interdependence is not well established in higher plants. Here, we propose that COPT2, a high-affinity copper transport protein, functions under copper and iron deficiencies in Arabidopsis (Arabidopsis thaliana). COPT2 is a plasma membrane protein that functions in copper acquisition and distribution. Characterization of the COPT2 expr…

Phylogenetic origin and transcriptional regulation at the post-diauxic phase of SPI1, in Saccharomyces cerevisiae

2012

15 pages, 4 figures, supplementary material

Starvation and temperature upshift cause an increase in the enzymatically active cell wall-associated glyceraldehyde-3-phosphate dehydrogenase protei…

2003

The cell wall-associated glyceraldehyde-3-phosphate dehydrogenase (cwGAPDH) activity in Saccharomyces cerevisiae increases (two- to 10-fold, depending on the strain) in response to starvation and temperature upshift. Assays using transformants carrying pTDH, a yeast centromer derivative plasmid containing the Candida albicans TDH3 gene (encoding GAPDH) fused in frame with the yeast SUC2-coding region for internal invertase, showed that starvation and/or temperature upshift result in a similar increase in both cwGAPDH and cell wall-associated invertase activities. In addition, this incorporation of GAPDH protein into the cell wall in response to stress does not require (i) de novo protein sy…

EFFECTS OF CELLULAR SHORT-TERM STARVATION ON CONVENTIONAL CHEMOTHERAPY RESPONSE IN HUMAN CANCER: UNDERSTANDING OF MOLECULAR MECHANISMS AND MICRORNAS …

Background: Short Term Starvation (STS) is a type of dietary restriction able to reduce tumorigenesis and cancer progression but molecular bases of this effect are still unclear. Aim: In vitro analysis of STS effects in presence of chemotherapy and evaluation of microRNAs (miRNAs) involvement. Results: STS affects the expression profiles of miRNAs involved in chemotherapy response leading to cancer cells sensitization and to healthy cells protection.

Effects of progressive decrease of feeding frequency and re-feeding on production parameters, stomach capacity and muscle nutritional value in rainbo…

2020

Abstract Feeds and feeding constitute the major part of costs in intensive aquaculture. Any action to reduce feeding costs without negatively affecting fish production parameters and flesh quality would improve profitability of farming. Therefore, we studied the effects of feeding frequency on production parameters, stomach capacity and nutritional value of muscle in juvenile rainbow trout (Oncorhynchus mykiss) in an experiment with two stages. First, during the nine-week “starvation period” we fed rainbow trout (initial weight c. 40 g) with four different feeding protocols in an attempt to adapt the fish to a progressive decrease in the number of feeding days. During the second stage, a fo…

Starvation endurance in the antTemnothorax nylanderidepends on group size, body size and access to larvae

2013

Social interactions in animal groups can buffer environmental stress and may enhance survival under unfavourable conditions. In the present study, the impact on starvation endurance of social group, access to larvae and cold shock is studied in the ant Temnothorax nylanderi Forster. Resource sharing is expected to lead to grouped workers surviving longer than isolated ones. Access to larvae may increase longevity if larvae serve as food, or may interfere with survival if they induce caring behaviour in workers. Cold shock serves as a stress factor and a negative influence on survival is expected. The results show that isolated workers have a shorter lifespan than grouped workers, which in t…

Cellular, physiological, and molecular adaptive responses of Erwinia amylovora to starvation.

2013

Erwinia amylovora causes fire blight, a destructive disease of rosaceous plants distributed worldwide. This bacterium is a nonobligate pathogen able to survive outside the host under starvation conditions, allowing its spread by various means such as rainwater. We studied E. amylovora responses to starvation using water microcosms to mimic natural oligotrophy. Initially, survivability under optimal (28 °C) and suboptimal (20 °C) growth temperatures was compared. Starvation induced a loss of culturability much more pronounced at 28 °C than at 20 °C. Natural water microcosms at 20 °C were then used to characterize cellular, physiological, and molecular starvation responses of E. amylovora. Ch…

Potential miRNAs involved in molecular pathways mediating the anticancer effects of short term starvation in breast cancer cells treated with doxorub…

2017

Background: In recent years, increasing evidences showed that several types of dietary approaches restricting food intake, including Short Term Starvation (STS), may exert a protective role against aging and other age-related pathologies as well as cancer. Interestingly, the dietary restriction showed significant anticancer effects able to prevent cancer onset, slow its progression and improve therapy response. Since recent studies showed that miRNAs may modulate sensibility/resistance to antiblastic therapy, the aim of our study was to investigate the STS-induced molecular changes in breast cancer cells treated with doxorubicin, focusing our attention on miRNA expression profile. Materials…

Effects of weekend starvation and the duration of daily feeding on production parameters of rainbow trout Oncorhynchus mykiss

2021

Abstract It would often be practical to starve the cultivated fishes over the weekends, e.g. to save in labour costs. We evaluated the possibility that domesticated juvenile rainbow trout (Oncorhynchus mykiss) could compensate for the lost growth of the 2-day weekend starvation by either hyperphagic response and/or by lower feed conversion ratio, compared to the fish fed every day in an 8-week experiment. Rainbow trout (initial weight c. 30 g, temperature 16 °C) starved during the weekends were able to increase feed intake during the weekdays clearly above the intake of the control fish after the first two weekends, also seen as an increase of the compensation coefficients over the last fou…