Search results for "steady state"
showing 10 items of 173 documents
Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolong…
2014
Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolonged pharmacodynamic effect -
Discussion of “Unsteady Stage-Discharge Relationships for Sharp-Crested Weirs” by Firouz Ghasemzadeh, Salah Kouchakzadeh, and Gilles Belaud
2021
I would like to thank the authors for writing this interesting article dealing with unsteady stage-discharge relationships for sharp-crested weirs. The operation of triangular and rectangular sharp-crested weirs in unsteady flow conditions was experimentally investigated. Results indicated the presence of looped rating curves, with transposition of the rising and falling limbs compared to that commonly observed in stream gauge ratings. The authors found that the deviation between steady and unsteady flow rates in the looped rating curves depends on the weir type and the hydrograph gradient (i.e., the temporal depth variation), especially when the latter changes rapidly. Finally, they propos…
Revisiting Current Concepts on the Tolerogenicity of Steady-State Dendritic Cell Subsets and Their Maturation Stages
2021
Abstract The original concept stated that immature dendritic cells (DC) act tolerogenically whereas mature DC behave strictly immunogenically. Meanwhile, it is also accepted that phenotypically mature stages of all conventional DC subsets can promote tolerance as steady-state migratory DC by transporting self-antigens to lymph nodes to exert unique functions on regulatory T cells. We propose that in vivo 1) there is little evidence for a tolerogenic function of immature DC during steady state such as CD4 T cell anergy induction, 2) all tolerance as steady-state migratory DC undergo common as well as subset-specific molecular changes, and 3) these changes differ by quantitative and qualitati…
Inflation dynamics in a model with firm entry and (some) heterogeneity
2014
We analyse the incidence of endogenous entry and firm TFP-heterogeneity on the response of aggregate inflation to exogenous shocks. We build up an otherwise standard DSGE model in which the number of firms is endogenously determined and firms differ in their steady state level of productivity. This splits the industry structure into firms of different sizes. Calibrating the different transition rates, across firm sizes and out of the market we reproduce the main features of the distribution of firms in Spain. We then compare the inflation response to technology, interest rate and entry cost shocks, among others. We find that structures in which large (more productive) firms predominate tend…
Fluorescence emission and enhanced photochemical stability of Zn(II)-5-triethyl ammonium methyl salicylidene ortho-phenylendiiminate interacting with…
2010
Abstract The photophysical and photochemical properties of the cationic Zn II complex of 5-triethyl ammonium methyl salicylidene ortho-phenylendiimine (ZnL 2+ ) interacting with native DNA were investigated by steady state and time-resolved fluorescence spectroscopies. Experimental results indicate that, in the presence of DNA, ZnL 2+ is efficiently protected from a photochemical process, which occurs when it is in the free state dispersed in aqueous solution. The analysis of the absorption and emission spectra of ZnL 2+ , both stored in the dark and after exposure to tungsten lamp light for 24 h, corroborated by quantum chemical calculations, allowed us to point out that ZnL 2+ undergoes a…
Renal and nonrenal clearances of ceftriaxone at the steady-state and its relation to plasma protein binding
1995
Abstract The effect of the saturable plasma protein binding of ceftriaxone on the elimination of this drug was studied under steady-state conditions in the rat. A concentration-dependent increase in the total, renal and nonrenal clearances of total drug (bound + unbound) was observed, and it was related to the increase in the ex vivo unbound fraction of ceftriaxone as the plasma concentration increased. The nonrenal clearance of the unbound ceftriaxone showed a statistically significant decrease as the plasma concentration of the unbound drug at the steady state increased, which indicates that the nonrenal elimination of the drug (mainly by biliary excretion) is a saturable process. Renal c…
Energy status and its control on embryogenesis of legumes: ATP distribution within Vicia faba embryos is developmentally regulated and correlated wit…
2003
To analyse the energy status of Vicia faba embryos in relation to differentiation processes, we measured ATP concentrations directly in cryosections using a quantitative bioluminescence-based imaging technique. This method provides a quantitative picture of the ATP distribution close to the in vivo situation. ATP concentrations were always highest within the axis. In pre-storage cotyledons, the level was low, but it increased strongly in the course of further development, starting from the abaxial region of cotyledons and moving towards the interior. Greening pattern, chlorophyll distribution and photosynthetic O2 production within embryos temporally and spatially corresponded to the ATP di…
Some diffusion equations with finite propagation speed
2007
We summarize some of our recent results on diffusion equations with finite speed of propagation. These equations have been introduced to correct the infinite speed of propagation predicted by the classical linear diffusion theory. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Assessment of the Thermo-mechanical Performances of a DEMO Water-Cooled Liquid Metal Blanket Module
2015
Within the framework of DEMO R&D activities, a research cooperation has been launched between ENEA-Brasimone, CEA-Saclay and the University of Palermo to investigate the thermo-mechanical behaviour of the outboard equatorial module of the DEMO1 Water-Cooled Lithium Lead (WCLL) blanket, both under normal operation and over-pressurization steady state scenarios. The research campaign has been carried out following a theoretical-computational approach based on the finite element method (FEM) and adopting a qualified commercial FEM code. In particular, two different three-dimensional FEM models of the WCLL blanket module have been set-up to be used for normal operation and over-pressurization a…
Control of Power Converters with Hybrid Affine Models and Pulse-Width Modulated Inputs
2021
In this paper, hybrid dynamical systems theory is applied to the analysis and control of switched converters with Pulse-Width Modulated (PWM) inputs. The system is described by a state-space model with continuous flows and discrete jumps, without averaged equations. The modulation effects are captured in full without using time-dependent signals, by enlarging the state vector to include the PWM waveform generation process. Furthermore, the sample-and-hold mechanism associated with the sampling frequency is also taken into account with this approach. A control law is proposed based on a Lyapunov function candidate. Furthermore, convergence sets and the steady state jitter, inherent to PWM-ba…