Search results for "stil"

The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models

2014

AbstractIn spite of the novel strategies to treat colon cancer, mortality rates associated with this disease remain consistently high. Tumour recurrence has been linked to the induction of resistance towards chemotherapy that involves cellular events that enable cancer cells to escape cell death. Treatment of colon cancer mainly implicates direct or indirect DNA-damaging agents and increased repair or tolerances towards subsequent lesions contribute to generate resistant populations. Resveratrol (RSV), a potent chemosensitising polyphenol, might share common properties with chemotherapeutic drugs through its indirect DNA-damaging effects reported in vitro. In this study, we investigated how…

Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction

2013

Accessibility of DNA is a prerequisite for both DNA damage and repair. Therefore, the chromatin structure is expected to have major impact on both processes, with opposite consequences for the stability of the genome. To analyse the influence of chromatin compaction on the generation and repair of various types of DNA modifications, we modulated the global chromatin structure of AS52 Chinese hamster ovary cells and HeLa cells by treatment with either histone deacetylase inhibitors or resveratrol and measured the repair kinetics of (i) pyrimidine dimers induced by ultraviolet B, (ii) oxidised purines generated by photosensitisation and (iii) single-strand breaks induced by H2O2, using an alk…

Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells

2002

Resveratrol is a natural polyphenolic compound produced by a number of plants and found in high amount in peanuts, seeds, grapes or berries as source of human nutrition. Epidemiological studies strongly suggest that resveratrol may act as a cancer chemopreventive compound. The mechanism by which resveratrol inhibits cell proliferation was studied in human colorectal tumor SW480 cell line. The results show that resveratrol strongly inhibits cell proliferation at the micromolar range in a time- and dose-dependent manner. Resveratrol appears to block the cell cycle at the transition --> G2/M since inhibition of [(3)H]-thymidine incorporation is not observed, while there is an increase of the c…

In vitro antioxidant properties, DNA damage protective activity, and xanthine oxidase inhibitory effect of cajaninstilbene acid, a stilbene compound …

2010

The antioxidant properties, DNA damage protective activities, and xanthine oxidase (XOD) inhibitory effect of cajaninstilbene acid (CSA) derived from pigeon pea leaves were studied in the present work. Compared with resveratrol, CSA showed stronger antioxidant properties, DNA damage protective activity, and XOD inhibition activity. The IC(50) values of CSA for superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide scavenging, reducing power, lipid peroxidation, and XOD inhibition were 19.03, 6.36, 39.65, 20.41, 20.58, and 3.62 μM, respectively. CSA possessed good protective activity from oxidative DNA damage. Furthermore, molecular docking indicated that CSA was more poten…

Per camins inussitats i sendes molt apartades. Contrabando de seda valenciana hacia Castilla durante la segunda mitad del siglo XVI

2015

Este artículo analiza la intensa corriente de contrabando de seda valenciana hacia Castilla, que se desarrolló durante la segunda mitad del siglo XVI. Entre otros factores, la creación del nou imposit de la seda en 1552 incentivó esta actividad ilícita, que llegó a convertirse en un modo de vida en las principales regiones productoras (especialmente la Ribera del Júcar) y un motivo constante de litigio para las autoridades, incapaces de frenar este tráfico ilícito. La política fiscal valenciana y el auge del contrabando de seda a Toledo lastró la sedería valenciana durante esta centuria, ya que dificultó el abastecimiento de materia prima de los telares de la ciudad de Valencia. Del mismo m…

Polish Yellow Sweet Clover (Melilotus officinalis L.) Honey, Chromatographic Fingerprints, and Chemical Markers

2017

A case study of Polish Melilotus officinalis honey was presented for the first time. Gas chromatography–mass spectrometry (GC-MS) (after steam distillation, Soxhlet extraction, ultrasonic solvent extraction, and solid phase extraction (SPE)) and targeted high performance liquid chromatography with a photodiode array detector (HPLC-PAD) were applied to determine the characteristic components of honey. While ubiquitous in most honeys, carbohydrates, terpene derivatives, and phenylacetic acid dominated in the Soxhlet extracts (25.54%) and in the application of SPE (13.04%). In addition, lumichrome (1.85%) was found, and may be considered as a marker of this honey. Due to the presence of these …

Interpunkcijas stilistiskās funkcijas latviešu modernisma prozā: 19. un 20. gs. mijā, 20. gs. pirmajā trešdaļā

1997

El "Cantar de Mio Cid" y algunos problemas históricos

1972

Datortehnikas ražotāja produkta un vizuālās identitātes vizuāli stilistiskie aspekti

2016

Šī diplomdarba mērķis ir uzzināt vizuālās identitātes vizuāli stilistiskās īpašības datortehnikas uzņēmumiem, kas specializējas datorkorpusu ražošanā, kā arī izstrādāt vizuālo identitāti un produkta dizainu datorkorpusu ražotājkompānijai „Vulcan”. Darbā tiek izklāstīta vizuālās identitātes vēsture un attīstība līdz mūsdienām; tiek aprakstīta koloristikas, burtveidola, logotipa un stila grāmatas nozīme uzņēmuma zīmolam. Darba pētījumā tiek izmantota kvantitatīvā un kvalitatīvā analīzes metode, lai noskaidrotu vizuālās identitātes stilistiskos aspektus, ko izmanto datortehnikas uzņēmumi. Arī tiek veikta aptauja par to, kā cilvēki uztver datortehnikas dizaina aspektus. Pētījuma jautājums: kāda…

REST arhitektūras stila pielietojums mūsdienās

2017

Mūsdienās arvien populārākas kļūst tīmekļa vietnes, kuras ir veidotas, balstoties uz REST arhitektūras stilu. Viens no iemesliem ir tāds, ka to atbalsta lielākā daļa no ietvariem un bibliotēkām, kā arī tas dod lielu kontroli pār lapu, ja to pielieto pareizi. Savukārt, pielietojot to nepareizi, ir iespējams ne tikai zaudēt daudzus piedāvātos plusus, bet arī padarīt lapu nedrošu pret uzbrukumiem. Bakalaura darba mērķis ir apskatīt, kā pielietot pareizi REST arhitektūras stilu, izpētīt, kādas ir iespējamās drošības problēmas, ja tas netiek pielietots pareizi, kā arī apskatīt, cik programmētāji ir zinoši par REST arhitektūras stilu un tā drošību. Darbā ir veikts gan teorētiskais, gan praktiskai…