Search results for "structural"

Ultracentrifugation studies on the native form of the first component of human complement (C1)

1976

Conformational investigation of α, β‐dehydropeptides. XI. Molecular and crystal structure of Ac‐(Z )‐ΔPhe‐NMe2 as compared to those of related molecu…

2003

A series of three homologous dimethyldiamides Ac-(Z)-ΔPhe-NMe2, Ac-L-Phe-NMe2 and Ac-DL-Phe-NMe2 have been synthesized and their structures determined from single-crystal X-ray diffraction data. To learn more about the conformational preferences of the compounds studied, the fully relaxed ϕ, ψ conformational energy maps on the free molecules of Ac-ΔAla-NMe2 and Ac-(Z)-ΔPhe-NMe2 were obtained with the HF/3-21G method and the calculated minima re-optimized with the DFT/B3LYP/6-31G** method. The crystal state results have been compared with the literature data. The studied dimethyldiamide Ac-ΔXaa-NMe2 combines the double bond in positions α, β and the C-terminal tertiary amide within one molec…

Influence of the quadratic term in the alongwind stochastic response of SDOF structures

1996

A parametric study, regarding the influence of the quadratic pressure term, which is often neglected in the literature, on the stochastic alongwind response of a single-degree-of-freedom (SDOF) structure subjected to wind action, is presented. The results are reported in terms of percentages of difference in the evaluation of the response, by considering and neglecting the quadratic pressure term. The changing parameters considered are: the terrain drag coefficient, the structure height, the structure natural radian frequency, the structure damping coefficient and the wind reference mean velocity. The response stochastic analysis has been carried out in the time domain, by means of the mome…

Determination of hydrodynamic drag forces and drag coefficients on human leg/foot model during knee exercise.

2000

Objective. The purpose of this laboratory experiment was to measure hydrodynamic drag forces in barefoot/hydro-boot conditions and accordingly, to determine the coefficients of drag on human leg/foot model during simulated knee extension–flexion exercise. Design. The prosthesis of the human lower leg was set in a water tank and connected into an isokinetic force dynamometer to measure resistive forces during knee motion. Background. Quantifying resistance for aquatic exercises has been a challenge in hydrotherapy. The use of models of foot/leg provides a practical method to calculate coefficients of drag and to estimate resistance for rehabilitation purposes in musculoskeletal and amputee p…

How is the inner circadian clock controlled by interactive clock proteins?

2015

AbstractMost internationally travelled researchers will have encountered jetlag. If not, working odd hours makes most of us feel somehow dysfunctional. How can all this be linked to circadian rhythms and circadian clocks? In this review, we define circadian clocks, their composition and underlying molecular mechanisms. We describe and discuss recent crystal structures of Drosophila and mammalian core clock components and the enormous impact they had on the understanding of circadian clock mechanisms. Finally, we highlight the importance of circadian clocks for the daily regulation of human/mammalian physiology and show connections to overall fitness, health and disease.

Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon

1978

13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum protein-binding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.

Ductility of Reinforced Concrete Members Externally Wrapped with Fiber-Reinforced Polymer Sheets

2007

The effectiveness of external wrapping with fiber-reinforced polymer for enhancing the curvature ductility of lightly reinforced concrete members is investigated. Referring to members with circular transverse cross sections, the performances in terms of both strength and ductility capacities are analyzed, and the predictive reliability of two different recent constitutive models, available in the literature and able to take into account the softening behavior of confined concrete, is checked. A parameter characterizing the effectiveness of the confining wrapping is proposed, and characteristic values are suggested. Moreover, referring to ductility increases due to confinement effects, a com…

Time-resolved X-ray scattering as a tool to probe heme proteins structural dynamics in solution

2013

Time-resolved wide-angle X-ray scattering (TR-WAXS) is a recently developed technique allowing to probe global structural changes of proteins in solution. We have used TR-WAXS to investigate large conformational changes of heme proteins (wild-type and mutant hemoglobin, neuroglobin, etc.) that cannot take place when these macromolecules are in a crystalline environment. Our data revealed detailed information on kinetic and thermodynamic properties of the investigated proteins and demonstrate the potentiality of the TR-WAXS technique.

Mode-superposition correction method for deterministic and stochastic analysis of structural systems

2001

The role played by the modal analysis in the framework of structural dynamics is fundamental from both deterministic and stochastic point of view. However the accuracy obtained by means of the classical modal analysis is not always satisfactory. Therefore it is clear the importance of methods able to correct the modal response in such a way to obtain the required accuracy. Many methods have been proposed in the last years but they are meaningful only when the forcing function is expressed by an analytical function. Moreover in stochastic analysis they fail for white noise excitation. In the paper a method able to give a very accurate response for both deterministic and stochastic input is p…

Inferring slowly-changing dynamic gene-regulatory networks

2015

Dynamic gene-regulatory networks are complex since the interaction patterns between their components mean that it is impossible to study parts of the network in separation. This holistic character of gene-regulatory networks poses a real challenge to any type of modelling. Graphical models are a class of models that connect the network with a conditional independence relationships between random variables. By interpreting these random variables as gene activities and the conditional independence relationships as functional non-relatedness, graphical models have been used to describe gene-regulatory networks. Whereas the literature has been focused on static networks, most time-course experi…