Search results for "structural"
showing 10 items of 5047 documents
Filling the Gap in the Metallacrown Family: The 9‐MC‐3 Chromium Metallacrown
2021
Abstract In this work, we report on a long‐sought missing complex in the metallacrown family. We synthesized and characterized the novel chromium metallacrown (MC) complex {CrIII(μ 2‐piv)3[9‐MCCr(III)N(shi)‐3](morph)3}⋅MeOH (in which shi3−=salicyl hydroxamate, piv=pivalate, and morph=morpholine). The MC with a 9‐MC‐3 cavity of kinetically inert chromium(III) ions was synthesized by a solvothermal reaction. Magnetization measurements reveal a high spin ground state.
9-cis-Retinoic acid enhances fatty acid-induced expression of the liver fatty acid-binding protein gene
1997
The role of retinoic acids (RA) on liver fatty acid- binding protein (L-FABP) expression was investigated in the well differentiated FAO rat hepatoma cell line. 9-cis-Retinoic acid (9-ci's-RA) specifically enhanced L-FABP mRNA levels in a time- and dose-dependent manner. The higher induction was found 6 h after addition of 10 -6 M 9-CK-RA in the medium. RA also enhanced further both L-FABP mRNA levels and cytosolic L-FABP protein content induced by oleic acid. The retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor (PPAR), which are known to be activated, respectively, by 9-c/s-RA and long chain fatty acid (LCFA), co-operated to bind specifically the peroxisome prol…
La patria potestad prorrogada y la patria potestad rehabilitada en el nuevo proyecto de ley de reforma de la legislación civil y procesal para el apo…
2021
It is intended to analyze and reflect in the present work about the institution of the extension of parental authority and parental authority rehabilitated in the new regulation in the Draft Law that reforms the civil and procedural legislation to support people with disabilities in the exercise of their legal capacity. In this project, the extended parental authority and the rehabilitated parental authority are eliminated from the scope of disability, following a criterion that demands the treatment of people with disabilities with the attention that their specific situation requires, eliminating a regime that seems contrary to the system of promoting the autonomy of adults with disabiliti…
A hybrid short read mapping accelerator
2013
Background The rapid growth of short read datasets poses a new challenge to the short read mapping problem in terms of sensitivity and execution speed. Existing methods often use a restrictive error model for computing the alignments to improve speed, whereas more flexible error models are generally too slow for large-scale applications. A number of short read mapping software tools have been proposed. However, designs based on hardware are relatively rare. Field programmable gate arrays (FPGAs) have been successfully used in a number of specific application areas, such as the DSP and communications domains due to their outstanding parallel data processing capabilities, making them a compet…
Variables predictoras de la satisfacción con la vida en personas mayores que participan en programas formales de aprendizaje
2017
Este estudio tiene como objetivo conocer la relación entre diferentes variables demográficas y el bienestar y satisfacción con la vida, y evaluar la capacidad predictora de la satisfacción con la vida en una muestra de personas mayores que participan en el Programa Universitario para Personas Mayores de la Universidad de Valencia. La OMS define envejecimiento activo y sano como el proceso de optimizar oportunidades para la salud y la participación. El modelo de envejecimiento exitoso propone el compromiso activo con la vida, a través del mantenimiento de relaciones interpersonales y de las actividades productivas. El aprendizaje en la vejez tiene un impacto positivo en el envejecimiento. Un…
Projecte d'investigació-acció: Violència escolar i integració social
2006
En aquest treball es presenta el Projecte d'Investigació-Acció realitzat pel grup Lisis de la Universitat de València. Des del model ecològic, l'interès està a analitzar i prevenir la conducta violenta entre iguals a l'escola. Per a això s'ha aplicat en una mostra de 1319 adolescents d'edats compreses entre els 11 i els 16 anys una bateria d'instruments. En aquest article s'exposa, a tall d'exemple, un dels models d'equacions estructurals calculats en aquesta investigació. En concret s'analitza l'efecte directe i l'indirecte del clima familiar en la conducta violenta entre iguals i en el context escolar.
Problemas multiplicativos relacionados con la división de fracciones : un estudio sobre su enseñanza y aprendizaje
2013
Los estudiantes tienen dificultades para asociar el enunciado de un problema multiplicativo con la operación que permite resolverlo; esta investigación identifica los tipos de problemas multiplicativos que los estudiantes reconocen como de división de fracciones. Mediante el análisis histórico-epistemológico de textos de enseñanza sobre tres épocas históricas y ocho períodos diferentes, se obtiene un listado de variables de enseñanza (algoritmos, sentidos de uso de fracción y de división de fracciones, representaciones, problemas), así como los valores de dichas variables. Se localizan en los textos consultados algunas reglas particulares y seis algoritmos generales, cuyo predominio ha vari…
Competence centres and peculiarities of their accounting: case of Latvia
2014
In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification
2022
International audience; Although botulinum neurotoxins (BoNTs) are among the most toxic compounds found in nature, their molecular mechanism of action is far from being elucidated. A key event is the conformational transition due to acidification of the interior of synaptic vesicles, leading to translocation of the BoNT catalytic domain into the neuronal cytosol. To investigate these conformational variations, homology modeling and atomistic simulations are combined to explore the internal dynamics of the sub-types BoNT/A1 (the most-used sub-type in medical applications) and BoNT/E1 (the most kinetically efficient sub-type). This first simulation study of di-chain BoNTs in closed and open s…
SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells
2023
Since infection with the novel coronavirus SARS-CoV-2 first emerged in Wuhan, China, in December 2019,the world has been battling the pandemic COVID-19. Patients of all ages and genders are now becoming infected with the new coronavirus variant (Omicron) worldwide, and its subvariants continue to pose a threat to health and life. This article provides a literature review of cardiovascular and gastrointestinal complications resulting from SARS-CoV-2 infection. COVID-19 primarily caused respiratory symptoms, but complications can affect many vital organs. SARS-CoV-2 binds to a human cell receptor (angiotensin-converting enzyme 2 – ACE2) that is predominantly expressed primarily in the heart a…