Search results for "structural"
showing 10 items of 5047 documents
Factors affecting Nigerian teacher educators’ technology integration : Considering characteristics, knowledge constructs, ICT practices and beliefs
2020
To provide a diverse comprehension of teachers' TPACK (Technological, Pedagogical, and Content Knowledge) and how TPACK is reflected in practice, this study examined teacher educators' (TEs') conceptions of technology integration. Specifically, the main objective of the study was to investigate the factors influencing Nigerian teacher educators' technology integration using a self-completion survey administered to Nigerian teacher educators from three schools in the southern region of Nigeria. We utilized the partial least squares structural equation modeling (PLS-SEM) approach for the data analysis. Two frameworks—TPACK and Second Information Technology in Education Study (SITES)— guided t…
Calidad de salas para música clásica
2013
Finding a parameter which allows establishing if a concert room is good for orchestral classical music performances or not is one of the main interests in room acoustics. However, rooms are usually characterized by average values of some acoustic parameters. From the optimal values mostly recognized, specialists can consider a room adequate or not for a certain use. In recent works, we have obtain we have obtained a model for classifying a room for classical music performances, from the reverberation time (T30), the lateral energy factor coefficient (LFC) and the listener envelopment (LEV). From this model, we can determine the quality maps for these rooms. In this paper, we show the qualit…
Discussion on “Experimental Deformation of Opalinus Clay at Elevated Temperature and Pressure Conditions: Mechanical Properties and the Influence of …
2021
AbstractThe testing procedure and results on saturated samples of Opalinus Clay in the work of Schuster et al. (Rock Mech Rock Eng https://doi.org/10.1007/s00603-021-02474-3, 2021) were conducted and presented using strain rates two to four orders of magnitudes higher than the rates needed to allow pore pressure equilibrium in the material, both in drained and undrained conditions. This leads to an erroneous estimation of the mechanical properties in saturated conditions. We discuss this aspect in the context of shale testing. We also discuss the effect of drying-induced fissuring on the mechanical properties of geomaterials tested in dry conditions.
Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase
1995
Processing of the hepatitis C virus polyprotein is accomplished by a series of cotranslational and posttranslational cleavages mediated by host cell signalases and two virally encoded proteinases. Of these the NS3 proteinase is essential for processing at the NS3/4A, NS4A/4B, NS4B/5A, and NS5A/5B junctions. Processing between NS3 and NS4A occurs in cis, implying an intramolecular reaction mechanism, whereas cleavage at the other sites can also be mediated in trans. Sequence analysis of the amino termini of mature cleavage products and comparisons of amino acid residues around the scissile bonds of various hepatitis C virus isolates identified amino acid residues which might contribute to su…
Climate Change in the Mediterranean Basin (Part II): A Review of Challenges and Uncertainties in Climate Change Modeling and Impact Analyses
2023
AbstractThe Mediterranean basin is particularly prone to climate change and vulnerable to its impacts. One of the most relevant consequences of climate change, especially for the southern Mediterranean regions, is certainly water scarcity as result of a reduction of surface runoff and groundwater levels. Despite the progress achieved in recent years in the field of climate change and its impact on water resources, results and outcomes should be treated with due caution since any future climate projection and derived implications are inevitably affected by a certain degree of uncertainty arising from each different stage of the entire modeling chain. This work offers a comprehensive overview…
How to untie G-quadruplex knots and why?
2021
International audience; For over two decades, the prime objective of the chemical biology community studying G-quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to obtain mechanistic interpretations. This strategy has been undoubtedly successful, as demonstrated by recent advances. However, these insights have also led to a fundamental rethinking of G4-targeting strategies: due to the prevalence of G4s in the human genome, transcriptome, and ncRNAome (collectively referred to as the G4ome), and their involvement in human diseases, should we continue developing G4-stabilizing ligands or should we invest in designing molecular tools to unfold G4s? Here, …
Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation.
2014
Autism Spectrum Disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies have investigated the role of de novo Copy Number Variants (CNVs) and microRNAs as important but distinct etiological factors in ASD. We developed a novel computational procedure to assess the potential pathogenic role of microRNA genes overlapping de novo CNVs in ASD patients. Here we show that for chromosomes # 1, 2 and 22 the actual number of miRNA loci affected by de novo CNVs in patients was found significantly higher than that estimated by Monte Carlo simulation of random CNV events. Out of 24 miRNA genes over-represented in CNVs from these three chromosomes only …
Temperamento y crianza en la construcción de la personalidad. conducta agresiva, inestabilidad y prosociabilidad [Effect of temperament and upbringin…
2004
Resumen La investigacion realizada persigue un doble objetivo. El primero se dirige a estudiar la relacion que se establece entre la estructura de la personalidad del adolescente y la manifestacion de la agresion, de la inestabilidad emocional y de la conducta prosocial. El segundo objetivo pretende analizar del peso que muestran los habitos de crianza en la emision de las conductas agresivas, inestables y prosociales. La muestra esta constituida por 531 adolescentes, chicos y chicas de edades comprendidas entre los 12 y los 16 anos, escolarizados en Centros Publicos y Concertados, que cursan la Etapa Educativa de la Educacion Secundaria Obligatoria. En atencion al procedimiento aleatorio, …
Reverse electrodialysis heat engine for sustainable power production
2017
Abstract Reverse Electrodialysis Heat Engine (REDHE) is a promising technology to convert waste heat at temperatures lower than 100 °C into electric power. In the present work an overview of the possible regeneration methods is presented and the technological challenges for the development of the RED Heat Engine (REDHE) are identified. The potential of this power production cycle was investigated through a simplified mathematical model. In the first part of the work, several salts were singularly modelled as possible solutes in aqueous solutions feeding the RED unit and the corresponding optimal conditions were recognized via an optimization study. In the second part, three different RED He…