Search results for "sun"
showing 10 items of 935 documents
Nintedanib in non-small cell lung cancer: from preclinical to approval
2015
Angiogenesis is a driving force of a tumor’s development. Targeting this process is an attractive option, as this is a feature shared by most of the solid tumors. A lot of antiangiogenic drugs have been developed following this path, including bevacizumab, sorafenib, sunitinib, vandetanib, ramucirumab, motesanib and many others. The latest drug of this class to be approved for patients with non-small cell lung cancer (NSCLC) was nintedanib, a triple angiokinase inhibitor. This molecule targets vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and fibroblast growth factor (FGF) pathways, avoiding the tumor’s switch to normal escape mechanisms. The pharmacokine…
ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy
2021
Funding Information: BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. Funding Information: NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. Funding Information: CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Rese…
Magnetohydrodynamic simulations of the ejection of a magnetic flux rope
2013
Context. Coronal mass ejections (CME's) are one of the most violent phenomena found on the Sun. One model to explain their occurrence is the flux rope ejection model. In this model, magnetic flux ropes form slowly over time periods of days to weeks. They then lose equilibrium and are ejected from the solar corona over a few hours. The contrasting time scales of formation and ejection pose a serious problem for numerical simulations. Aims: We simulate the whole life span of a flux rope from slow formation to rapid ejection and investigate whether magnetic flux ropes formed from a continuous magnetic field distribution, during a quasi-static evolution, can erupt to produce a CME. Methods: To …
Numerical procedures and their practical application in PV modules analyses. Part I: air mass
2019
Abstract The subject of the article is aspects of PV modules and cells measurement, with the use of natural sunlight. A light source is an important element during calibration and measurements of solar cells and modules. All designers of artificial light sources try to recreate natural light using so called measurement tables. The correctly performed measurement, i.e. meeting all the appropriate atmospheric conditions, guarantees obtaining the result with the use of a reference spectrum. The article has two main aims. The first aim of the article is to answer the question asked earlier - if the sunlight spectrum registered in appropriate conditions is so good that it serves as the reference…
A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein surviv…
2011
Abstract Background and purpose Novel strategies to overcome an irradiation resistant phenotype may help to increase therapeutic efficacy in glioblastoma multiforme. The present study aimed to elucidate radiation sensitizing properties of artesunate, a semi synthetic derivate of artemisinin and to assess factors involved in this effect. Materials and methods LN229 and U87MG cells were treated with various concentrations of artesunate and radiation response was determined by a colony forming assay. Cell numbers, apoptosis induction, cell cycle distribution, and DNA repair following combined modality treatment were monitored by MTT-, caspase 3/7 assay, cytofluorometry, and γ-H2AX foci formati…
Application of a radiative cooling model to daily minimum temperature prediction
1985
A model of exponential decrease of temperature is applied to the study of night cooling in an agricultural area of citrus orchards located near the Valentian Coast (Spain). A set of annual average parameters which determine that cooling is obtained by using temperature measurements at different levels during two years. These parameters appear to be representative of the thermal behaviour of the area of study. The attainment of such parameters allows a prediction of the minimum temperatures of the area to an accuracy of £1.5 K, knowing the temperature at sunset and some time later.
Detection of lactobacillic acid in low erucic rapeseed oil--A note of caution when quantifying cyclic fatty acid monomers in vegetable oils.
2010
International audience; The purpose of this work was to identify an unknown component which has been detected during the analysis of cyclic fatty acid monomers (CFAMs) in low erucic acid rapeseed oils (LEAR). A sample of crude LEAR was transformed into fatty acid methyl esters (FAMEs) and hydrogenated using PtO2. The hydrogenated sample was fractionated by reversed-phase high-performance liquid chromatography (RP-HPLC) and the fraction containing the CFAMs transformed into picolinyl esters. Analysing these picolinyl derivatives by gas-liquid chromatography coupled to mass spectrometry (GC-MS) showed that the unknown product observed in LEAR is the 11,12-methylene-octadecanoic acid. This cyc…
Efficient flow injection and sequential injection methods for spectrophotometric determination of oxybenzone in sunscreens based on reaction with Ni(…
2001
Spectrophotometric determination of a widely used UV-filter, such as oxybenzone, is proposed. The method is based on the complexation reaction between oxybenzone and Ni(II) in ammoniacal medium. The stoichiometry of the reaction, established by the Job method, was 1:1. Reaction conditions were studied and the experimental parameters were optimized, for both flow injection (FI) and sequential injection (SI) determinations, with comparative purposes. Sunscreen formulations containing oxybenzone were analyzed by the proposed methods and results compared with those obtained by HPLC. Data show that both FI and SI procedures provide accurate and precise results. The ruggedness, sensitivity and LO…
Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective Europe…
2022
BACKGROUND Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12���g���dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (���week 3) onwards. OBJECTIVE To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN A multicentre observational study. SETTING The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthe…
THE THEORIES AND PRACTICES OF LOPE AND MORATÍN: THE NEW THEATRE AND 'THE NEW PLAY'
2021
En este artículo, por primera vez, se ponen en relación las teorías teatrales de dos dramaturgos españoles que crearon escuela: Lope de Vega y Leandro Fernández de Moratín. Dos siglos separan sus creaciones, pero ambos pretendieron renovar la escena con sus poéticas, ambos pretendieron una «nueva comedia» que rompiera con las tradiciones teatrales inmediatamente anteriores. Las obras dramáticas de uno y otro autor, en realidad se sitúan en polos opuestos en cuanto a su extensión; la de Lope abarca más de cuatrocientos títulos, mientras que Moratín apenas tiene en su haber media decena de piezas. El más fecundo e internacional poeta dramático español y el más comedido de entre los dramaturgo…