Search results for "swelling"

Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind ra…

2021

Background The preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. Material and Methods The researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor v…

N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: In vivo study with TNBS-induced colitis model in rats

2011

5-Aminosalicylic acid (5-ASA) loaded N-Succinyl-chitosan (SucCH) microparticle and freeze-dried system were prepared as potential delivery systems to the colon. Physicochemical characterization and in vitro release and swelling studies were previously assessed and showed that the two formulations appeared to be good candidates to deliver the drug to the colon. In this work the effectiveness of these two systems in the treatment of inflammatory bowel disease was evaluated. In vitro mucoadhesive studies showed excellent mucoadhesive properties of both the systems to the inflamed colonic mucosa. Experimental colitis was induced by rectal instillation of 2,4,6-trinitrobenzene sulfonic acid (TNB…

Training-induced protection and effect of terminated training on exercise-induced damage and water content in mouse skeletal muscles.

1995

Muscle swelling in connection with training-induced protection against exercise-induced damage and the disappearance of the protective adaptation after termination of training was studied in male NMRI-mice, aged 8 weeks at the beginning of the experiment. Mice were randomly assigned to several different treatment groups (training, training-exercise, exercise, detraining, detraining-exercise, together with their respective controls). Training and prolonged exercise sessions were performed by running uphill (6 degrees) on a motor-driven treadmill. Muscle damage was estimated by the total activity of beta-glucuronidase and water content from the red parts of m. quadriceps femoris (MQF), m. sol…

Characterization of rubberized asphalt for railway sub-ballast. Improvements in the mix-design, performance features and rational methodology of HMA_…

2018

(STR) can be incorporated into asphalt mixtures in two different methods, which are referred to as the wet-dry process. The blending of recycled rubber (CRM) with asphalt has been used for years, and several manufacturing processes have been developed in Europe as well as in the USA. The use of a bituminous sub-ballast layer has been pointed out as an exciting alternative to the granular sub-ballast design traditionally applied in most railroad tracks. Frequently, unbound granular materials are replaced by bituminous sub-ballast that provide additional benefits to the subgrade protection. Much research has been conducted on finding other alternative material to be used as a modifier in asph…

CHARACTERIZATION OF RUBBERIZED ASPHALT FOR RAILWAY SUB-BALLASTS

Tesi di dottorato sotto la supervisione del professore Gaetano di Mino del Dipartimento di Ingegneria Civile di Palermo), come borsista Marie-Curie all'interno del progetto SUPRITN 2013/2017. Il mio lavoro e la linea della ricerca riguarda i conglomerati bituminosi con granulato di gomma per lo strato di sub-ballast nelle linee ferroviarie. L’attività di ricerca comprende il mix-design dell’asfalto con aggiunta di gomma, la caratterizzazione e le prestazioni per la ferrovia in termini di comportamento meccanico e lo smorzamento delle vibrazioni. In particolare con l’avvento dell’alta velocità, diversi studi hanno evidenziato ottime caratteristiche fisico-meccaniche per ciò che riguarda il c…

Hyaluronic Acid Derivative with Improved Versatility for Processing and Biological Functionalization

2016

A hydrophobic/amino functionalized derivative of hyaluronic acid (HA-EDA-C18 ) has been processed by salt leaching technique as porous scaffold without need of chemical crosslinking. Aim of this work is to demonstrate the improved versatility of HA-EDA-C18 in terms of processing and biological functionalization. In particular, the chemical procedure to tether thiol bearing RGD peptide has been described. Moreover, the possibility to load and to control the release of slightly water soluble effectors has been demonstrated by using dexamethasone. First, the swelling and degradation profiles of the scaffolds have been investigated, then the evaluation of metabolic activity of bovine chondrocyt…

Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships

2017

Thin xyloglucan-based hydrogel films have been synthetized and characterized in the prospect of producing wound dressings. Polyvinyl alcohol (PVA) and glycerol (Gro) were added to have an optimal combination of softness, conformability and resilience. Physical hydrogels have been transformed into permanent covalent hydrogels by reaction with glutaraldehyde (GA). Network structure-process-property relationships are discussed on the account of the results of several complementary characterizations: FTIR, rheology, thermal analysis, morphological analysis, moisture retention and swelling measurements. Selected formulations were also subjected to preliminary in vitro cytotoxicity tests. The phy…

2020

For medical application, easily accessible biomaterials with tailored properties are desirable. Collagen type I represents a biomaterial of choice for regenerative medicine and tissue engineering. Here, we present a simple method to modify the properties of collagen and to generate collagen laminates. We selected three commercially available collagen sheets with different thicknesses and densities and examined the effect of rose bengal and green light collagen crosslinking (RGX) on properties such as microstructure, swelling degree, mechanical stability, cell compatibility and drug release. The highest impact of RGX was measured for Atelocollagen, for which the swelling degree was reduced f…

Fracture toughness of synthesised high-performance epoxies subject to accelerated water aging

2018

Abstract The effects of water uptake on the fracture toughness of epoxy systems with high glass-transition temperatures (Tg above 170 °C) are investigated. Aging conditioning has been conducted in hot water, followed by a desorption conditioning in a room temperature dry-airborne. Water aging determines plasticisation effects and crosslink-density modifications, revealed by reductions of the Tg. It is less known how such modifications influence the material fracture toughness. In this study, Single Edge Notched Bending samples have been tested according to standards, to evaluate the KIC fracture toughness at different stages of water absorption-desorption. The characterisation has been supp…

Anomalous water diffusion in epoxy/carbon nanoparticle composites

2019

Abstract Water absorption-desorption-resorption and swelling were studied for a DGEBA-based amine-cured epoxy resin filled with four types of carbon nanoparticles: multiwall carbon nanotubes (MWCNT), graphite nano-platelets (GnP), expanded graphite platelets, and carbon black. Nanocomposites are characterised by lower diffusivity (down to 20% for epoxy/GnP) and increased water sorption capacity compared to the neat epoxy. Anomalous water absorption and swelling of nanocomposites is finely described by the diffusion-relaxation model. The relaxation times, considered as quantitative indicators of changes in segmental mobility of the polymer, increased with addition of nanoparticles and decrea…