6533b861fe1ef96bd12c59df
RESEARCH PRODUCT
Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships
Marta Di CarloPasquale PiconeSabina AlessiMaria Antonietta SabatinoAlessia AjovalasitSimona TodaroClelia DispenzaDaniela Giacomazzasubject
Materials Chemistry2506 Metals and AlloysGlycerolMaterials sciencePolymers and PlasticsCell Survival02 engineering and technologymacromolecular substances010402 general chemistry01 natural sciencesPolyvinyl alcoholchemistry.chemical_compoundStructure-Activity RelationshipRheologyStructure-properties relationshipsMaterials ChemistrymedicineHumansComposite materialFourier transform infrared spectroscopyXyloglucanGlucansStructure-property relationshipWound HealingPolymers and PlasticOrganic Chemistrytechnology industry and agricultureHydrogels021001 nanoscience & nanotechnology0104 chemical sciencesXyloglucanThermogravimetryHydrogelchemistryA549 CellsGlutaralPolyvinyl AlcoholWound dressingSelf-healing hydrogelsThermogravimetryXylansGlutaraldehydeSettore CHIM/07 - Fondamenti Chimici Delle TecnologieSwellingmedicine.symptom0210 nano-technologyRheologyBandages Hydrocolloiddescription
Thin xyloglucan-based hydrogel films have been synthetized and characterized in the prospect of producing wound dressings. Polyvinyl alcohol (PVA) and glycerol (Gro) were added to have an optimal combination of softness, conformability and resilience. Physical hydrogels have been transformed into permanent covalent hydrogels by reaction with glutaraldehyde (GA). Network structure-process-property relationships are discussed on the account of the results of several complementary characterizations: FTIR, rheology, thermal analysis, morphological analysis, moisture retention and swelling measurements. Selected formulations were also subjected to preliminary in vitro cytotoxicity tests. The physical and mechanical properties of some of the xyloglucan-based hydrogel films produced, combined with absence of cytotoxicity, make them suitable candidates for integration with sensors to monitor the wound healing process and further biological investigations in animal models.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-07-28 |