Search results for "terpenoids"

showing 10 items of 34 documents

Enzyme-catalysed transformations of ent-kaurane diterpenoids

2005

Several acetyl derivatives of linearol, atractyligenin and atractylitriol were obtained through enzyme-catalysed acetylation and deacetylation reactions. In most reactions lipases showed regio- and stereoselective behaviour, allowing a family of novel compounds to be prepared. Fil: Monsalve, Leandro Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y …

Química OrgánicaACETYLATIONENZYME CATALYSISChemistryStereochemistryDEACETYLATIONOrganic ChemistryENT-KAURANESCiencias QuímicasDITERPENOIDSPhysical and Theoretical ChemistryEnt kauraneCIENCIAS NATURALES Y EXACTAS
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Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides.

2008

The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid ( 5), new in the literature. The cytotoxic activities of elasclepic acid ( 1), ENT-atis-16-en-19-oic acid ( 2), ent-beyer-15-en-19-oic acid ( 3), ent-kaur-16-en-19-oic acid ( 4) and meoidic acid ( 5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.

StereochemistryElaeoselinum asclepium subsp. meoides Umbelliferae diterpenoids meoidic acid cytotoxic activityPharmaceutical ScienceBiologyPharmacognosyAnalytical Chemistrychemistry.chemical_compoundCell Line TumorDrug Discoveryotorhinolaryngologic diseasesAcetoneCytotoxic T cellAnimalsCytotoxicityCell ProliferationPharmacologyMolecular StructureOrganic ChemistrySettore CHIM/06 - Chimica OrganicaElaeoselinum asclepium subsp. meoidesAntineoplastic Agents PhytogenicTerpenoidRatsComplementary and alternative medicinechemistryPhytochemicalMolecular MedicineDiterpeneDiterpenesApiaceaePlanta medica
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Clerodane diterpenoids from Salvia splendens.

2006

Four new clerodane diterpenoids, salvisplendins A-D (1-4), have been isolated from an acetone extract of the flowers of SalVia splendens, together with an artifact (5), arising from salvisplendin D (4) by addition of diazomethane, and the already known clerodane olearin (6). The structures of the new compounds (1-5) were established mainly by 1D and 2D NMR spectroscopic studies and, in the case of salvisplendin A (1), by chemical correlation with splenolide B (7). Complete 1H and 13C NMR assignments for olearin (6), not published hitherto, are also reported.

StereochemistryPharmaceutical ScienceFlowersSalviaAnalytical ChemistryDiterpenes Clerodanechemistry.chemical_compoundFour new clerodane diterpenoids salvisplendins A-D (1-4) have been isolated from an acetone extract of the flowers of SalVia splendens together with an artifact (5) arising from salvisplendin D (4) by addition of diazomethane and the already known clerodane olearin (6). The structures of the new compounds (1-5) were established mainly by 1D and 2D NMR spectroscopic studies and in the case of salvisplendin A (1) by chemical correlation with splenolide B (7). Complete 1H and 13C NMR assignments for olearin (6) not published hitherto are also reportedDrug DiscoveryOrganic chemistrySalviaNuclear Magnetic Resonance BiomolecularPharmacologychemistry.chemical_classificationPlants MedicinalbiologyMolecular StructureChemistryDiazomethaneOrganic ChemistryCarbon-13 NMRbiology.organism_classificationChemical correlationTerpenoidComplementary and alternative medicineItalyMolecular MedicineDiterpeneTwo-dimensional nuclear magnetic resonance spectroscopyLactoneJournal of natural products
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New insights into the bioactivity of cucurbitacins

2005

The cucurbitacins are a group of tetracyclic triterpenoids derived from the cucurbitane skeleton and found primarily in the Cucurbitaceae family. These triterpenoids, present in free or glycosidic form, are generally responsible for the bitter taste of the plants that contain them and are probably the principal cause of the antifeedant effects observed for such plants. Several plants used in traditional medicine to treat both inflammatory diseases as well as various types of tumors are rich in cucurbitacins, a fact which has given rise to several studies concerning their potential use as anti-inflammatory and anticancer agents. Nevertheless, since many cucurbitacins are extremely toxic, rel…

Terpenechemistry.chemical_compoundCucurbitacinsTriterpenoidTraditional medicinechemistryTetracyclic triterpenoidsBiological activityPharmacologyBiologyCucurbitaneBitter taste
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Chromatogrphic Profiles of Polyphenols and Terpenoids in the Herbs of Some Thymus L. Represntatives

2022

The aim of the work. To perform the identification of phenolic compounds and terpenoids in the aerial parts of Thymus pulegioides L. (cultivar ‘2/6-07’), Thymus richardii Pers. (cultivar 'Fantasy') and Thymus vulgaris L. (cultivar ‘Jalos’) using thin layer chromatography (TLC), as well as to conduct the gaschromatographic analysis of Thymus richardii essential oil. Materials and Methods. The TLC method was used in this study for the qualitative analyses of polyphenols and non-polar compounds in the aerial part of three Thyme (Thymus L.) species from the Lamiaceae Martinov family cultivated in Kherson region (Ukraine). The volatile compounds were determined in the essential oil of Thymus ric…

Thymus pulegioidesThymus vulgarisherbterpenoidsGC/MSTLCThymus richardiipolyphenolscultivarФармацевтичний Часопис
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Pyrolysis-gas chromatography : mass spectrometry analysis of di- and triterpenoids

2017

The objective of this work was to study a specific class of extractives existing in lignocellulosic biomass and more precisely in wood materials, and their thermochemical behavior during pyrolysis. The focus was centered on the class of terpenes and terpenoids; specifically two model compounds, abietic acid and betulinol, were chosen to represent the subclasses of di- and triterpenoids, respectively. The model compounds were investigated via pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) and the main objective was to study their product profiles and characteristic fragmentations, as well as the influence of specific variables (pyrolysis temperature and time) on pyrolysis products…

abietic acidterpeenitterpenoidsbetulinolkuivatislausPy-GC/MSpyrolysistriterpeenit
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An ent-kaurane from Sideritis huber-morathii

1996

WOS: A1996VW86500030

biologyStereochemistryS-CaesareaPlant ScienceGeneral MedicineHorticultureLabiataebiology.organism_classificationBiochemistryTerpenoidchemistry.chemical_compoundchemistrySideritis Huber-MorathiiSideritis3718-Triacetyl-FoliolDiterpeneMolecular BiologyEnt kauraneEnt-Kaurane Diterpenoids
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The diterpenoids from the genus Sideritis

2006

ABSTRACT: The genus Sideritis consists of 100-150 or more species, growing mainly in the countries around the Mediterranean area. The genus is particularly rich in diterpenoids, occurring in almost all the species, and shows many different carbon skeleta. Several species are still used in traditional medicine. Recent studies indicated the occurrence of interesting biological activities, like anti-inflammatory, antibacterial, antimicrobial, anti-HIV replication, antifeedant, antiulcerogenic, analgesic, and antihypoglycaemic.

biologyTraditional medicineGenusBotanyditerpenoids SideritisSideritisMediterranean areaSettore CHIM/06 - Chimica Organicabiology.organism_classificationAntimicrobial
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Preparation of 9a-Fluorinated Sesquiterpenic Drimanes and Evaluation of Their Antifeedant Activities

2010

19 pages, figures, and tables statistics.

chemistry.chemical_classificationNatural productsKetoneStereochemistryTerpenoidsOrganic ChemistryElectrophilic fluorinationBiological activitiesTotal synthesisTotal synthesisFluorineEnolChemical synthesischemistry.chemical_compoundchemistryWittig reactionOrganic chemistryPhysical and Theoretical ChemistryCarbonylationCyanohydrin
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Crystal structure, Hirshfeld surface analysis and electrostatic potential study of naturally occurring cassane-type diterpenoid Pulcherrimin C monohy…

2019

Single crystal X-ray diffraction analysis and Hirshfeld surface analysis of the title compound were carried out to analyse qu­anti­tatively the inter­molecular inter­actions involved in the crystal packing. The electrostatic potential surface was generated over the Hirshfeld surface to visualize the potential active sites.

crystal structureCrystal structurecassane-type diterpenoids010402 general chemistry010403 inorganic & nuclear chemistryRing (chemistry)01 natural sciencesResearch Communicationslcsh:ChemistryCrystalchemistry.chemical_compoundFuranHirshfeld surface analysisGeneral Materials SciencebiologyHydrogen bondGeneral ChemistryCondensed Matter PhysicsCaesalpinia pulcherrimabiology.organism_classificationTerpenoid0104 chemical sciencesCaesalpinia pulcherrimapulcherrimin CCrystallographyelectrostatic potentiallcsh:QD1-999chemistryActa Crystallographica Section E Crystallographic Communications
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