Search results for "testi"
showing 10 items of 4607 documents
Recomendaciones para la determinación de HER2 en cáncer de mama. Consenso Nacional de la Sociedad Española de Anatomía Patológica ( SEAP ) y de la So…
2009
La identificación de los carcinomas de mama con amplificación/sobreexpresión de HER2 es crítica en la práctica clínica diaria ya que estas neoplasias requieren un tratamiento específico que incluye el uso de terapias dirigidas. Tanto las técnicas de hibridación in situ como las técnicas inmunohistoquímicas son métodos apropiados para la identificación de cánceres de mama HER2 positivos. Sin embargo, numerosos estudios, incluidos los desarrollados por la Asociación para la Garantía de Calidad en Patología de la SEAP (AGCP) y la experiencia de centros de referencia nacionales en la determinación de HER2 han puesto de manifiesto importantes problemas de reproducibilidad entre laboratorios. Por…
Polymeric microcontainers improve oral bioavailability of furosemide.
2016
Microcontainers with an inner diameter of 223 μm are fabricated using the polymer SU-8, and evaluated in vitro, in situ and in vivo for their application as an advanced oral drug delivery system for the poorly water soluble drug furosemide. An amorphous sodium salt of furosemide (ASSF) is filled into the microcontainers followed by applying a lid using Eudragit L100. It is possible to control the drug release in vitro, and in vitro absorption studies show that the microcontainers are not a hindrance for absorption of ASSF. In situ perfusion studies in rats are performed with ASSF-filled microcontainers coated with Eudragit and compared to a furosemide solution. The absorption rate constant …
Rhinomanometry: point of care test (POCT) for allergic rhinitis in children?
2021
Allergic rhinitis (AR) is a global health problem: its prevalence is 23% in Europe, although it is underestimated because as many as 45% of the cases remain undiagnosed. Globally, almost 500 million people suffer from AR, which shows its increasing incidences. The diagnostic course of AR is based on clinical history, supported by anterior rhinoscopy. This inspects the anterior part of the nasal cavity accompanied by allergic sensitivity tests (cutaneous allergic skin tests or specific immunoglobulin E levels). The availability of standardised diagnostic procedures is able to provide objective evaluations of inflammatory situation, and the degree of nasal obstruction may give an advantage in…
Leaps and bounds: geographical and ecological distance constrained the colonisation of the Afrotemperate by Erica.
2018
Abstract Background The coincidence of long distance dispersal (LDD) and biome shift is assumed to be the result of a multifaceted interplay between geographical distance and ecological suitability of source and sink areas. Here, we test the influence of these factors on the dispersal history of the flowering plant genus Erica (Ericaceae) across the Afrotemperate. We quantify similarity of Erica climate niches per biogeographic area using direct observations of species, and test various colonisation scenarios while estimating ancestral areas for the Erica clade using parametric biogeographic model testing. Results We infer that the overall dispersal history of Erica across the Afrotemperate…
Metabolism and fate of triazophos in rats
1976
The excretion patterns and tissue residues were determined after single and repeated oral dosing of rats with triazophos-14C Within 4 days after a single oral dose 76.3 % of the 14C was excreted in the urine and 21.0% in the faeces. After daily application for 12 days 69.5–83.4% of the label was eliminated in urine and 30.9–18.1 % in the faeces. Following prolonged application, however, elimination is distinctly slower. Distribution of radioactive residues in organs and tissue in both test series showed no appreciable or critical concentrations of radioactivity, with the exception of the gastrointestinal tract (contents and walls). Unchanged triazophos and l-phenyl-1,2,4-triazol-3-ol-3-14C …
Flush-Crash Experiments in Drosophila
1989
In 1968, Hampton Carson (1968) proposed the founder-flush-crash model, a new model of speciation, which readily lends itself to experimental testing in the laboratory (Carson 1971).
The reaction structure of the LEDA research centre: Development and design
2017
In the last twenty years, the field of earthquake engineering experienced a noticeable improvement. The results of experimental and theoretical researches have contributed to the development of modern technical codes, which provide innovative solutions for the structural assessment and new design approaches. Despite this large amount of improvements, several open questions are still open, and the need for large scale testing has been deeply proved and discussed. A new research facility, namely the Laboratory of Earthquake engineering and Dynamic Analysis (LEDA), has been recently completed at the University of Enna "Kore". This research centre, funded with a grant from Italian Ministry of E…
Empirical model evaluation and hypothesis testing
2016
Chapter 5 deals with the empirical model evaluation and the testing of hypotheses. It starts out with the evaluation of the measurement and the structural models, using the PLS algorithm. After the evaluation of the complete model, moderating effects are examined by conducting group comparisons (section 5.4.1) and by investigating interaction effects (5.4.2). After that, selected constructs are further examined by exploratory data analysis (section 5.5).
Expresión diferencial de proteínas en el íleon de ratón asociadas con el desarrollo de infecciones crónicas por Echinostoma caproni
2015
Entre las enfermedades parasitarias que afectan a la humanidad, las helmintiasis intestinales destacan por su gran morbilidad, ya que actualmente afectan a más de 2000 millones de personas y causan grandes pérdidas económicas relacionadas con la ganadería y la veterinaria. Echinostoma caproni es un trematodo intestinal que, por sus características, es utilizado en numerosos estudios como modelo experimental para determinar los factores por los que se resuelve una infección aguda o se desarrolla una infección crónica causada por helmintos intestinales. En este trabajo se analizó la expresión diferencial de proteínas durante una primoinfección, después de un tratamiento farmacológico y durant…
SIFT Matching by Context Exposed
2023
This paper investigates how to step up local image descriptor matching by exploiting matching context information. Two main contexts are identified, originated respectively from the descriptor space and from the keypoint space. The former is generally used to design the actual matching strategy while the latter to filter matches according to the local spatial consistency. On this basis, a new matching strategy and a novel local spatial filter, named respectively blob matching and Delaunay Triangulation Matching (DTM) are devised. Blob matching provides a general matching framework by merging together several strategies, including rank-based pre-filtering as well as many-to-many and symmetri…