Search results for "tm"
showing 10 items of 27732 documents
Lesión compleja del codo pediátrico: fractura de cóndilo externo asociada a luxación posteromedial de codo.
2020
espanolAntecedentes y objetivo: La fractura de condilo externo asociada a una luxacion posteromedial de codo es una entidad muy rara, de la cual existen muy pocos casos publicados. Nuestro objetivo es presentar un caso complejo tratado en nuestro centro, el diagnostico, el tratamiento elegido, y el seguimiento a las 9 semanas. Caso clinico: varon de 5 anos con una luxacion posteromedial de codo asociada a una fractura de condilo externo, diagnosticada mediante TC y tratada de forma quirurgica mediante un abordaje anterior sobre el codo, reduccion abierta y osteosintesis con agujas de Kirschner. Resultados: los resultados clinicos y radiologicos a las 9 semanas son excelentes, presentando un…
Wireless ECG and cardiac monitoring systems: State of the art, available commercial devices and useful electronic components
2021
Abstract Wireless ElectroCardioGram (ECG) systems are employed in manifold application fields: tele-monitoring, sport applications, support to ageing people at home, fetal ECG, wearable devices and ambulatory monitoring. The presence of cables often hinders user’s free movements, alongside clinicians’ routine operations. Therefore, wireless ECG systems are desirable. This paper aims at reviewing the solutions described in the literature, besides commercially available devices and electronic components useful to setup laboratory prototypes. Several systems have been developed, different in terms of the adopted technology; when approaching the development of a wireless ECG system, some import…
Immunomodulatory and Hematopoietic Effects of Recombinant Human Interleukin-6 in Patients with Advanced Renal Cell Cancer
1996
Interleukin-6 (IL-6) is a cytokine with pleiotropic biologic activities on B cells, T cells, and hematopoietic progenitors. The present study was undertaken to assess pharmacodynamic effects of subcutaneous administration of IL-6 on blood counts, immunologic parameters, and acute-phase reactants. Blood samples were taken from patients with advanced renal cell cancer participating in a phase II trial of recombinant human IL-6. Multiparameter FACS analyses of peripheral blood mononuclear cells were performed using antibodies against CD3, CD4, CD8, HLA-DR, CD56, CD28, CD38, CD19, sIgM, and sIgG. Serum levels of IL-10, soluble CD23 (sCD23), sCD25, IL-1 receptor antagonist protein (IL-1RA), solu…
Storm Energy Flux Characterization along the Mediterranean Coast of Andalusia (Spain)
2019
This paper investigates wave climate and storm characteristics along the Mediterranean coast of Andalusia, for the period 1979&ndash
Relapsed and/or Refractory Mantle Cell Lymphoma: What Role for Temsirolimus?
2012
Mantle Cell Lymphoma (MCL) is associated with a dismal prognosis. Recently, along with the improved understanding of the pathophysiology of this disease, new first line regimens have been established and in addition novel treatment options have entered the clinical arena. In consequence, prognosis of the disease has fortunately improved. We here focus on the rationale, current clinical knowledge and future concepts of Temsirolimus, an inhibitor of mTOR, in the treatment of MCL. At this time this drug has been shown to be effective as single agent for relapsed disease and early combination data show promising results. In addition, with a brief outline of other treatment options, we aim to g…
Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain.
2004
The endogenous ligands of cannabinoid receptors, also known as endocannabinoids, have been implicated in many physiological and pathological processes of the central nervous system. Here we show that the levels of the two major endocannabinoids, anandamide and 2-arachidonoyl-glycerol (2-AG), in four areas of the rat brain, change dramatically between the light and dark phases of the day. While anandamide levels in the nucleus accumbens, pre-frontal cortex, striatum and hippocampus were significantly higher in the dark phase, the opposite was observed with 2-AG, whose levels were significantly higher during the light phase in all four regions. We found that the activity of the fatty acid ami…
Analysis of relapse after transplantation in acute leukemia: A comparative on second allogeneic hematopoietic cell transplantation and donor lymphocy…
2018
Relapse of acute leukemia (AL) after allogeneic hematopoietic cell transplantation (Allo-HCT) entails a dismal prognosis. In this scenario, donor lymphocyte infusions (DLIs) and second Allo-HCT are two major approaches. We compared outcomes of AL patients treated for relapse with DLI or second Allo-HCT after receiving debulking therapy. In total, 46 patients were included in the study; 30 (65%) had acute myeloid leukemia and 16 (35%) had acute lymphoblastic leukemia. The median age was 38 years (range 4-66). Twenty-seven patients received a second Allo-HCT and 19 patients received DLI. The median follow-up of the cohort was 273 days (range 9-7013). Overall survival (OS), disease-free surviv…
Revising midlatitude summer temperatures back to A.D. 600 based on a wood density network
2015
Annually resolved and millennium-long reconstructions of large-scale temperature variability are primarily composed of tree ring width (TRW) chronologies. Changes in ring width, however, have recently been shown to bias the ratio between low- and high-frequency signals. To overcome limitations in capturing the full spectrum of past temperature variability, we present a network of 15 maximum latewood density (MXD) chronologies distributed across the Northern Hemisphere extratropics. Independent subsets of continental-scale records consistently reveal high MXD before 1580 and after 1910, with below average values between these periods. Reconstructed extratropical summer temperatures reflect n…
The pituitary gland prevents shock-associated death by controlling multiple inflammatory mediators
2018
Abstract Bacterial infections cause a major burden of disease worldwide. Sepsis and septic shock are life-threatening complications of infections. The hypothalamic-pituitary-adrenal (HPA) axis initiates the release of endogenous glucocorticoids that modulate the host stress response and acute inflammation during septic shock. It is an ongoing controversial debate, if therapeutic manipulations of the HPA axis could benefit the clinical situation in the context of shock. Here, we have studied Long Evans rats with hypophysectomy followed by endotoxic shock. The shock-associated lethality was substantially higher in hypophysectomized rats as compared to control mice after cranial sham surgery (…
Optimal contract length for biodiversity conservation under conservation budget constraint
2014
We examine the optimal length of a contract period in a conservation program with payments for ecosystem services aiming at protecting biodiversity on privately owned forests. The government chooses the number of stands and the length of contracts so as to maximize biodiversity benefits under a binding conservation budget. We examine the implication of two alternative budgets: a separate budget for each period (periodic budget) or one budget that to be used in all periods (intertemporal budget). The impact of the budget type shows up in the fact that with intertemporal budget choice set is larger and more high quality stands are available for contracting. Based on theoretical characterizati…