Search results for "tolerance"

Sublingual immunotherapy in children.

2018

A General Mathematical Model for the Simulation of Common Faults in Three‐ phase Voltage Source Inverters

2013

In the last years the fault problem in power electronics has been more and more investigated both from theoretical and practical point of view. This paper analyzes the problem of faults modeling in a three phase voltage source inverter(VSI) and presents a model of a VSI able to simulate both unfaulty and faulty conditions when one or more devices go broken. In the past the fault problem was faced step by step considering the fault on each single device building a model for each case. The model hereafter presented solves this drawback through the introduction of the concept of the Healthy Device Binary Variable (HDBV) and the more general Healthy Leg Binary Variable (HLBV) showing also as th…

Grover’s Search with Faults on Some Marked Elements

2018

Grover’s algorithm is a quantum query algorithm solving the unstructured search problem of size [Formula: see text] using [Formula: see text] queries. It provides a significant speed-up over any classical algorithm [3]. The running time of the algorithm, however, is very sensitive to errors in queries. Multiple authors have analysed the algorithm using different models of query errors and showed the loss of quantum speed-up [2, 6]. We study the behavior of Grover’s algorithm in the model where the search space contains both faulty and non-faulty marked elements. We show that in this setting it is indeed possible to find one of marked elements in [Formula: see text] queries. We also analyze…

A new strategy to assure compliance with soil loss tolerance at a regional scale

2023

The relevant erosive effects of extraordinary rainfall events due to climate change require establishing soil conservation strategies to prevent damages due to hydrogeological instability. The “tolerable” soil loss, i.e., the maximum soil loss compatible with sustainable soil use, represents a quantitative target to establish the effectiveness of actions to control soil erosion. In this paper, a new approach to defining the condition corresponding to a tolerable soil loss is proposed. At first, using the statistical analysis of the measured annual values of the rainfall erosivity factor, the cover and management factor CT, for which the maximum tolerable soil loss is equal to the annual soi…

Induction of hapten-specific tolerance by interleukin 10 in vivo.

1994

Interleukin 10 (IL-10) is released during the induction phase of contact sensitivity and was shown in prior functional studies to convert epidermal Langerhans cells (LC) from potent inducers of primary immune responses to specifically tolerizing cells in vitro. To investigate whether IL-10 also subserves the function of a tolerizing agent in vivo ears of BALB/c or C3H mice were injected intradermally with 1-2 micrograms of recombinant mouse (rm)IL-10 8 h before epicutaneous application of 3% trinitrochlorobenzene (TNCB; a contact allergen). As a control, mice were injected with phosphate-buffered saline or IL-10 plus neutralizing amounts of anti-IL-10 mAb. 5 d later, mice were challenged wi…

The Ability of Variant Peptides to Reverse the Nonresponsiveness of T Lymphocytes to the Wild-Type Sequence p53264–272 Epitope

2002

Abstract Recently, we observed that CTL specific for the wild-type (wt) sequence p53264–272 peptide could only be expanded ex vivo from PBMC of a subset of the HLA-A2.1+ normal donors or cancer patients tested. Surprisingly, the tumors of the responsive patients expressed normal levels of wt p53 and could be considered unlikely to present this epitope. In contrast, tumors of nonresponsive patients accumulated mutant p53 and were more likely to present this epitope. We sought to increase the responsive rate to the wt p53264–272 peptide of PBMC obtained from normal donors and patients by identifying more immunogenic variants of this peptide. Two such variants were generated by amino acid exch…

Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance

2012

Background Allergic contact dermatitis is one of the most common occupational diseases. A main protective mechanism in those who do not develop allergic contact dermatitis is tolerance induction by repeated exposure to low doses of contact allergen, which is termed low zone tolerance (LZT). The mechanisms that determine the tolerance induction in subjects with LZT are still elusive. Objective We performed analysis of the role of CD4 + CD25 + forkhead box protein 3 (FOXP3)–positive regulatory T (Treg) cells and dendritic cells (DCs) in mice with LZT. Methods Mechanisms of tolerance induction were analyzed in a murine model of LZT by using FOXP3 and IL-10 reporter mice, as well as mice that a…

Large scale preparation of human MHC class II+ integrin beta(1)+ Tregs.

2010

Abstract The human CD4 + CD25 + FoxP3 + regulatory T cell population (Tregs) contains both MHC class II + and MHC class II − cells. MHC class II + Tregs belong to the integrin α 4 β 1 + subpopulation and exclusively execute contact-dependent suppressive activity. Here we present a method optimized for isolation of these MHC class II expressing Tregs from large leukaphereses products using magnetic microbeads that achieves a reproducible purity of more than 90% and enables the use of this small-sized Treg population in pre-clinical application and basic research.

Effects of Regulatory T Cell–Dendritic Cell Interactions on Adaptive Immune Responses

2014

The limited efficacy of chemo- or radiotherapy against neoplasias necessitates the development of complementary therapeutic strategies. Tumor immunotherapy represents a promising approach as it harnesses the potential of the host immune system to recognize and eradicate transformed cells. So far, T cell-based immunotherapy still suffers from a striking discrepancy between the induction of tumor-specific immune responses in experimental settings and therapeutic immunity in clinically relevant conditions. However, therapeutic approaches targeting immune regulatory mechanisms have lately shown encouraging results and have initiated long-lasting tumor control in patients. Therefore, a deeper un…

Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation

2009

Abstract The development of inflammatory diseases implies inactivation of regulatory T (Treg) cells through mechanisms that still are largely unknown. Here we showed that mast cells (MCs), an early source of inflammatory mediators, are able to counteract Treg inhibition over effector T cells. To gain insight into the molecules involved in their interplay, we set up an in vitro system in which all 3 cellular components were put in contact. Reversal of Treg suppression required T cell–derived interleukin-6 (IL-6) and the OX40/OX40L axis. In the presence of activated MCs, concomitant abundance of IL-6 and paucity of Th1/Th2 cytokines skewed Tregs and effector T cells into IL-17–producing T cel…