Search results for "traffic"

Driving impairment and crash risk in Parkinson disease: A systematic review and meta-analysis

2018

ObjectivesTo provide the best possible evidence base for guiding driving decisions in Parkinson disease (PD), we performed a meta-analysis comparing patients with PD to healthy controls (HCs) on naturalistic, on-the-road, and simulator driving outcomes.MethodsSeven major databases were systematically searched (to January 2018) for studies comparing patients with PD to HCs on overall driving performance, with data analyzed using random-effects meta-analysis.ResultsFifty studies comprising 5,410 participants (PD = 1,955, HC = 3,455) met eligibility criteria. Analysis found the odds of on-the-road test failure were 6.16 (95% confidence interval [CI] 3.79–10.03) times higher and the odds of sim…

Simulation-Based Analysis of "What-If" Scenarios with Connected and Automated Vehicles Navigating Roundabouts.

2022

Despite the potential of connected and automated vehicles (CAVs), there are still many open questions on how road capacity can be influenced and what methods can be used to assess its expected benefits in the progressive transition towards fully cooperative driving. This paper contributes to a better understanding of the benefits of CAV technologies by investigating mobility-related issues of automated vehicles operating with a cooperative adaptive cruise control system on roundabout efficiency using microscopic traffic simulation. The availability of the adjustment factors for CAVs provided by the 2022 Highway Capacity Manual allowed to adjust the entry capacity equations to reflect the pr…

Contribution to the cooperative management of conflictual spaces between autonomous vehicles

2017

The continuous increase in the number of vehicles has constantly led to innovation to improve the regulation of road traffic. Today, vehicle automation and inter-vehicular communication make possible a new approach: the autonomous and cooperative intersection (ACI) in which autonomous vehicles communicate to negotiate their right of way at the intersection. Theoretically more effective, safer and more economical than traditional approaches, its implementation and deployment constitute a scientific and technological challenge. In this paper, we propose several contributions supporting this development: a longitudinal and lateral vehicle control strategy designed to work with information disc…

Sexual Exploitation in the Destination Country

2020

When the vulnerability of Nigerian and Romanian women in human trafficking is concerned, it is not only important to understand the causes that led the victim into a situation of trafficking, but also to understand the factors that maintain the individual in a situation of victimisation. However, this does not mean that these factors are separated according to the different phases of trafficking. On the contrary, it demonstrates that the accumulation of different factors can generate a higher or lower level of vulnerability, as well as the balance of factors affecting the women during the different phases. Therefore, in this chapter I will put forward a general analysis of the different fac…

A New Scalable and Cost-Effective Congestion Management Strategy for Lossless Multistage Interconnection Networks

2005

In this paper, we propose a new congestion management strategy for lossless multistage interconnection networks that scales as network size and/or link bandwidth increase. Instead of eliminating congestion, our strategy avoids performance degradation beyond the saturation point by eliminating the HOL blocking produced by congestion trees. This is achieved in a scalable manner by using separate queues for congested flows. These are dynamically allocated only when congestion arises, and deallocated when congestion subsides. Performance evaluation results show that our strategy responds to congestion immediately and completely eliminates the performance degradation produced by HOL blocking whi…

Congestion Avoidance Using DYnamic COdec MAnagement: A solution for ISP

2005

The large diffusion of VoIP is an essential key for the success of emerging Internet service providers. These ISPs conflict with the interests of historical and predominant network maintainers which often control the network infrastructure and telephone services. To win this competition, emerging ISPs have to adopt strategic QoS solutions which will capture the attention of network users and phone clients. This paper presents a solution which is able to obtain the same performance of a 64 Kbps channel reducing the costs for over-provisioning network bandwidth. DyCoMa is a mechanism studied for VoIP applications in network with a limited bandwidth for multimedia services. It works preventing…

Protein traffic is an intracellular target in alcohol toxicity

2011

Eukaryotic cells comprise a set of organelles, surrounded by membranes with a unique composition, which is maintained by a complex synthesis and transport system. Cells also synthesize the proteins destined for secretion. Together, these processes are known as the secretory pathway or exocytosis. In addition, many molecules can be internalized by cells through a process called endocytosis. Chronic and acute alcohol (ethanol) exposure alters the secretion of different essential products, such as hormones, neurotransmitters and others in a variety of cells, including central nervous system cells. This effect could be due to a range of mechanisms, including alcohol-induced alterations in the d…

CHARACTERIZATION OF SHIP AND WILDFIRE EMISSION TRANSPORT EVENTS IN SOUTHERN SICILY, BASED ON BLACK CARBON OBSERVATIONS ANALYSIS DURING 2015 – 2016 AT…

DHEA-Bodipy–a functional fluorescent DHEA analog for live cell imaging

2009

International audience; The androgen dehydroepiandrosterone (DHEA) has been reported to protect neuronal cells against dysfunction and apoptosis. Several signaling pathways involved in these effects have been described but little is known about the intracellular trafficking of DHEA. We describe design, synthesis and characterization of DHEA-Bodipy, a novel fluorescent DHEA analog. DHEA-Bodipy proved to be a functional DHEA derivative: DHEA-Bodipy (i) induced estrogen receptor α-mediated gene activation, (ii) protected PC12 rat pheochromocytoma cells against serum deprivation-induced apoptosis, and (iii) induced stress fibers and focal adhesion contacts in SH-SY5Y human neuroblastoma cells. …

Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cance…

2005

AbstractIn this report we show, by confocal analysis of indirect immunofluorescence, that the type-1 cannabinoid receptor (CB1R), which belongs to the family of G-protein-coupled receptors, is expressed on the plasma membrane in human breast cancer MDA-MB-231 cells. However, a substantial proportion of the receptor is present in lysosomes. We found that CB1R is associated with cholesterol- and sphyngolipid-enriched membrane domains (rafts). Cholesterol depletion by methyl-β-cyclodextrin (MCD) treatment strongly reduces the flotation of the protein on the raft-fractions (DRM) of sucrose density gradients suggesting that CB1 raft-association is cholesterol dependent. Interestingly binding of …