Search results for "trend"
showing 10 items of 404 documents
Transdermal therapy and diagnosis by iontophoresis
1997
Iontophoresis, the use of an electric current to drive charged molecules across the skin, has the potential to expand the feasible range of drugs for transdermal administration significantly. This method of delivery is being examined carefully with respect to higher-molecular-weight therapeutics (in particular, peptides and small proteins), which cannot be absorbed following oral administration and for which, at this time, an invasive injection remains the only option. In addition, the procedure of so-called 'reverse' iontophoresis would appear to represent a truly noninvasive approach for diagnostic monitoring of blood chemistry.
Changing Trends in Drug Prescription and Causes of Treatment Discontinuation of First Biologic Over Ten Years in Psoriasis in the Spanish Biobadaderm…
2020
Background and objectives: Current psoriasis guidelines do not usually include recommendations about first line classical or biologic treatment. The objectives of this study were: to describe shifts in the prescription of the first biological treatment, and to compare treatment withdrawal and rates of adverse events over ten years. Material and methods: Biobadaderm registry was analyzed to describe: first biological prescription in bio-naive patients, adverse events rate and reasons for drug withdrawal comparing three periods of time (2008-2010, 2011-2014, 2015-2018). Results: Anti-TNF drugs were the most prescribed biological drug from 2008 to 2010. Ustekinumab has become the most prescrib…
Carga global, regional y nacional de neurológicas. Desórdenes, 1990-2016: un análisis sistemático para el Global Estudio de la carga de enfermedad 20…
2019
Publisher´s version (útgefin grein).
Development of innovative approaches for evaluating drought vulnerability and selecting innovative practices for managing water shortage (in Sicily)
2013
The climate, especially with regard to the precipitation and the evapotranspiration processes, plays a fundamental role in the vegetational patterns formation and modifications. The pilot project here described tries to evaluate in a quantitative way the impact of different climatic regimes (current or future) on vegetation health status and its physiological processes. In particular, an ecohydrological approach has been adopted in order to carry out an analysis of the potential climate changes influence on the vegetation state in a typical Mediterranean environment, such as the Sicilian one.
Evolutionary trends in arvicolids and the endemic murid Mikrotia - New data and a critical overview
2014
Abstract The study of evolutionary rates dates back to the work of Simpson and Haldane in the 1940s. Small mammals, especially Plio-Pleistocene arvicolids (voles and lemmings), are particularly suited for such studies because they have an unusually complete fossil record and exhibit significant evolutionary change through time. In recent decades, arvicolids have been the focus of intensive research devoted to the tempo and mode of evolutionary change and the identification of trends in dental evolution that can be used to correlate and date fossil sites. These studies have raised interesting questions about whether voles and lemmings had unique evolutionary trajectories, or show convergent …
Finnish vocational education and training in comparison: Strengths and weaknesses
2014
International journal for research in vocational education and training 1 (2014) 2, S. 81-106
Market trends in Spanish higher education
1997
Abstract Higher education in Spain broke away from its close dependency on the State in the last decade. In this paper we analyze the steps undertaken by the Spanish higher education system which has allowed market influences to grow in recent years. We analyze the historical framework and legal changes which have facilitated market trends in higher education. We consider the influence of these market trends on the financial and organizational structure of universities. We conclude that, though the steps are still hesitant, market-like elements are increasingly affecting every aspect of higher education life.
Survey of organochlorines in Finnish watercourses by caged mussel method
2002
Monitoring organochlorine compounds with caged common lake mussels (Anodonta piscinalis) in the pulp and paper mill recipient watercourses of Finland annually from 1984 produced many statistically significant time trends. A decrease of chlorophenols and chloroguaiacols originating from chlorobleaching were observed in all recipients in parallel with the decreasing discharges from the mills. Metabolites of chlorophenols, chloroanisoles and chloroveratroles were constant. Significantly elevated PCB concentrations were measured in four watercourses. At two of these areas, the PCB concentrations were constant. In contrast, a statistically significant increase of PCB (and DDE) was found at one r…
The effect of round-off error on long memory processes
2011
We study how the round-off (or discretization) error changes the statistical properties of a Gaussian long memory process. We show that the autocovariance and the spectral density of the discretized process are asymptotically rescaled by a factor smaller than one, and we compute exactly this scaling factor. Consequently, we find that the discretized process is also long memory with the same Hurst exponent as the original process. We consider the properties of two estimators of the Hurst exponent, namely the local Whittle (LW) estimator and the Detrended Fluctuation Analysis (DFA). By using analytical considerations and numerical simulations we show that, in presence of round-off error, both…
On the international co-movement of natural interest rates
2022
Using quarterly data for 10 OECD countries and the Euro area and a Kalman filtering technique, we investigate the international co-movement among natural interest rates. We show that the US is the main source of global spillovers and global/common factors appear to be key drivers of such co-movement. Indeed, global liquidity is a net transmitter of shocks, while quantitative easing (QE) and the US Dollar are net recipients of shocks. We also find that total spillovers among natural interest rates have been rising since the late nineties, spiking at around economic re-cessions, periods of US monetary policy tightening, the global financial crisis and the Eurozone sovereign debt crisis. From …