Search results for "undernutrition"
showing 10 items of 25 documents
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis…
2020
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.
Impact of Undernourishment on the Pharmacokinetics of Erlotinib and Gefitinib in Rats
2017
The relationship between nutritional status and pharmacokinetics has been previously studied for classical anticancer drugs, but this relationship remains unexplored for modern therapies involving targeted drugs and new administration routes. In this context, the main objective of this thesis was to evaluate, in undernourished and well-nourished Wistar rats, the impact of undernourishment on the pharmacokinetics of erlotinib and gefitinib, two novel orally administered targeted-drugs. The research investigation was divided into three main experiments: • Evaluation of analytical and molecular alterations associated with undernourishment • In situ intestinal perfusion studies • In vivo pharma…