Search results for "uva"
showing 10 items of 2916 documents
"Heittäydy vapauteen" : avantgarde ja Kauko Lehtisen taiteen murros 1961-1965
2007
Ulla Huhtamäki tarkastelee tutkimuksessaan taidemaalari Kauko Lehtisen (s.1925) taiteen murrosta vuosina 1961-1965. Lehtinen lähti Pariisiin kevättalvella 1961 etsimään uusia vaikutteita muuttaakseen omaa työskentelytapaansa, joka oli alkanut tuntua ”nyppimiseltä”. Lehtinen näki Pariisissa mm. uusrealistien ja uusdadaistien taidetta. Hän näki esim. Robert Rauschenbergin ja Alberto Burrin näyttelyt. Impasse Ronsin taiteilijakorttelissa Lehtinen näki Jean Tinguylen ateljeen edessä isot romukasat ja Niki de Saint Phallen ampumassa rikki väripusseja. Lehtinen tunsi olevansa ajan hermolla. Tämän matkan aikana Lehtisen työskentelyssä tapahtui syvällinen muutos. Hän hylkäsi visuaalisen mallin käyt…
Etusivun politiikkaa : yhteiskunnallisten toimijoiden representointi suomalaisissa sanomalehtiuutisissa 1987-2003
2004
FL Jukka Holmbergin journalistiikan väitöskirjan ”Etusivun politiikkaa. Yhteiskunnallisten toimijoiden representointi suomalaisissa sanomalehtiuutisissa 1987-2003.” tarkastustilaisuus. Vastaväittäjänä professori Pertti Suhonen (Tampereen yliopisto) ja kustoksena professori Raimo Salokangas.Jukka Holmberg tutki puoluetaustan ja sitoutumattomuuden vaikutusta sanomalehtien pääuutissivujen politiikan uutisiin 1980-luvun lopulta 2000-luvulle tultaessa eli aikana, jolloin Suomessa siirryttiin puoluepohjaisen lehdistöjärjestelmän loppuvaiheista täysin markkinavetoiseen järjestelmään. The research assesses the development of subjectivity and partiality in Finnish political journalism as the party p…
PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells
2014
Background and Purpose PPARβ enhances insulin sensitivity in adipocytes and skeletal muscle cells, but its effects on insulin signalling in endothelial cells are not known. We analysed the effects of the PPARβ/δ (PPARβ) agonists, GW0742 and L165041, on impaired insulin signalling induced by high glucose in HUVECs and aortic and mesenteric arteries from diabetic rats. Experimental Approach Insulin-stimulated NO production, Akt-Ser 473 and eNOS-Ser 1177 phosphorylation, and reactive oxygen species (ROS) production were studied in HUVECs incubated in low- or high-glucose medium. Insulin-stimulated relaxations and protein phosphorylation in vessels from streptozotocin (STZ)-induced diabetic rat…
Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections
2021
The overall CoCID concept is centred on providing virologists with a next-generation imaging device, which, through increased penetration and depth of focus, as well as through high natural contrast and sensitivity to organelle density (including virus-related organelles), will produce higher-fidelity ultrastructural images of whole intact cells. These insights will, in turn, help increase our understanding of the links between the structural reorganisation of cells and the mechanisms of viral entry, replication, assembly, and egress in cells. CoCID will provide this valuable imaging capability in the form of a compact lab-scale device that will greatly improve the accessibility of soft X-r…
Structural changes induced by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel-based morphometry study
2014
[Abstract.] Music is a highly complex and versatile stimulus for the brain that engages many temporal, frontal, parietal, cerebellar, and subcortical areas involved in auditory, cognitive, emotional, and motor processing. Regular musical activities have been shown to effectively enhance the structure and function of many brain areas, making music a potential tool also in neuro- logical rehabilitation. In our previous randomized controlled study, we found that listening to music on a daily basis can improve cognitive recovery and improve mood after an acute mid- dle cerebral artery stroke. Extending this study, a voxel-based morphometry (VBM) analysis utilizing cost function masking was perf…
Latvijas Vēstures Institūta Žurnāls. 2021, Nr. 1 (113)
2021
LU Latvijas vēstures institūta LU ilgtermiņa saistību izpilde 2020.-2022. g. ("Latvijas Vēstures Institūta Žurnāls")
New prospective in treatment of Parkinson's disease: Studies on permeation of ropinirole through buccal mucosa
2012
The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic conditions. Ropinirole, widely used in treatment of motor fluctuations of Parkinson's disease, passes the buccal mucosa. Flux and permeability coefficient values suggested that the membrane does not appear a limiting step to the drug absorption. Nevertheless, an initial lag time is observed but the input rate can be modulated by permeation enhancement using limonene or by application of electric fields. Absorption improvement was accompanied by the …
Treatment Results In Acute Myeloid Leukemia Over a Time Period Of 20 Years: Analysis Of The German-Austrian Acute Myeloid Leukemia Study Group (AMLSG)
2013
Abstract Background Overall survival (OS) in acute myeloid leukemia (AML) treated with intensive chemotherapy has improved over the last 20 year especially in younger adults (18-60 years) but still remains poor in older patients (>60 years) (Döhner et al. Blood 2010). The German-Austrian AMLSG performed controlled prospective treatment trials since 1993 starting with a risk-adapted approach (phase I, 1993-1997), followed by randomized and risk-adapted treatment strategies based on cytogenetic risk groups (phase II, 1997-2002); since 2003 addition of differentiating agents and HiDAC inhibitors to intensive induction therapy was evaluated (phase III, 2003-2007). Of note, until 2007 younger…
Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet
2019
Abstract Since the comprehensive recommendations for the management of acute promyelocytic leukemia (APL) reported in 2009, several studies have provided important insights, particularly regarding the role of arsenic trioxide (ATO) in frontline therapy. Ten years later, a European LeukemiaNet expert panel has reviewed the recent advances in the management of APL in both frontline and relapse settings in order to develop updated evidence- and expert opinion–based recommendations on the management of this disease. Together with providing current indications on genetic diagnosis, modern risk-adapted frontline therapy, and salvage treatment, the review contains specific recommendations for the …
Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography
2009
Objective: In order to perform effective translational research for cancer therapy, we need to employ preclinical models which reflect the clinical situation. The purpose of this study was to quantitatively compare the vascular architecture of human colorectal cancer and experimental tumour models to determine the suitability of animal models for vascular studies and antivascular therapy.Methods: In this study we investigated the three-dimensional properties of colonic tumour vasculature in both human clinical tissues (normal mucosa control [n = 20], carcinoma [n = 20] and adenoma In = 61) and murine colorectal xenografts (LS147T [n = 6] and SW1222 [n = 6]). Scanning Electron Microscope Ste…