6533b7d1fe1ef96bd125c4ba
RESEARCH PRODUCT
Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections
Kenneth FahyTony McenroePablo GastaminzaAxel EkmanNicola F. FletcherRalf BartenschlagerVenera WeinhardtMaija Vihinen-rantaDunja SkokoDimitri ScholzEva Pereirosubject
2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)viruksetSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CelltutkimuslaitteetBiologymikroskopiawater windowinfektiot03 medical and health sciences0302 clinical medicineherpesvirussoft x-ray microscopymedicinehepatiitti C -virusElectrical and Electronic Engineeringherpesvirukset030304 developmental biology0303 health scienceshepatiitti E -virusSARS-CoV-2röntgensäteilySARS-CoV-2-virusHepatitis Cmedicine.diseaseHepatitis EVirologyAtomic and Molecular Physics and Optics3. Good healthElectronic Optical and Magnetic Materialsmedicine.anatomical_structurekuvantaminenfotoniikka030220 oncology & carcinogenesiscell structure imaginghepatiittiviruksetSoft x-ray microscopyhepatitis Ehepatitis Csolubiologiadescription
The overall CoCID concept is centred on providing virologists with a next-generation imaging device, which, through increased penetration and depth of focus, as well as through high natural contrast and sensitivity to organelle density (including virus-related organelles), will produce higher-fidelity ultrastructural images of whole intact cells. These insights will, in turn, help increase our understanding of the links between the structural reorganisation of cells and the mechanisms of viral entry, replication, assembly, and egress in cells. CoCID will provide this valuable imaging capability in the form of a compact lab-scale device that will greatly improve the accessibility of soft X-ray microscopy for the virologists' consortium within the CoCID project as well as the broader disease research community worldwide.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-06-01 |