Search results for "vaccination"

mRNA Vaccination and Personalized Cancer Therapy

2014

Nucleic acid vaccines link two prerequisites for success, namely, the delivery of molecularly defined antigens as vaccine targets of interest and an inherent adjuvant activity. As compared to DNA-based approaches, in vitro-transcribed messenger RNA (mRNA) is a safer drug format due to the adjustable, transient expression and lack of genomic integration. In contrast to viral vector vaccines, mRNA vaccination is not limited by the emergence of immune responses against antigens produced by the viral vector backbones. Thus, mRNA vaccines are particularly attractive for cancer immunotherapy for which induction of clinically meaningful antigen-specific immune responses depends on repeated immuniz…

Cytokines and Toll-Like Receptors in the Immune Response to Influenza Vaccination

2014

Toll-like receptors (TLRs) are involved in immunogenicity. However, little information is available on the role of TLRs in the immune response to vaccination against influenza virus. The aim of the study was to analyze the relationship between the immunogenic response to influenza vaccine and the presence of soluble forms of TLRs and selected cytokines in the serum. There were two groups of subjects participating in the main protocol of the study: 55 chronically hemodialyzed patients (Group A) and 55 healthy volunteers (Group B) participated in the study. Both groups were vaccinated against influenza using a subunit Agrippal vaccine. The concentrations of human TNF-α, IL-1β/IL-1F2, IL-6, an…

The Role of Self-Assembling Lipid Molecules in Vaccination

2018

Abstract The advent of vaccines represents one of the most significant advances in medical history. The protection provided by vaccines has greatly contributed in reducing the number of cases of infections and most notably to the eradication of small pox. A large number of new technologies and approaches in vaccine development are currently being investigated with the goal of providing the basis for the next generation of prophylactics against an ever-expanding list of emerging and reemerging pathogens. In this chapter, we will focus on the role of lipids and lipid self-assembling vesicles in new and promising vaccination approaches. We will start by describing how lipids can induce activat…

On a stochastic disease model with vaccination

2006

We propose a stochastic disease model where vaccination is included and such that the immunity isn’t permanent. The existence, uniqueness and positivity of the solution and the stability of disease free equilibrium is studied. The numerical simulation is done.

Increasing Vaccine Acceptance and Uptake: A Review of the Evidence

2021

This article reviews the latest research on behavioral interventions to increase vaccine acceptance and uptake identifying the policies that work and underlying the determinants of their success. We focus primarily on studies that appeared after the publication of Brewer et al.’s (2017) in-depth survey of the behavioral literature on vaccination. We identify four major types of interventions that were tested in the lab, online or in the field: social norms-based interventions, opting-out strategies, reminders and recalls, and loss-framed/gain-framed messages (tailored to a particular population or not). Studies covered in this article can be a valuable resource to researchers as well as to …

Post H1N1 vaccination narcolepsy–cataplexy with decreased CSF beta-amyloid

2012

Vakcinācija priekšlaikus un laikā dzimušajiem bērniem Latvijā

2019

Ievads: Vakcinācija būtiski samazinājusi daudzu nopietnu slimību izplatību pasaulē. Lai gan priekšlaikus dzimuši zīdaiņi ir vairāk jutīgi pret infekcijām, viņu vakcinācija bieži vien tiek atlikta vai arī veikta pēc atvieglinātas programmas. Tā kā imunizācija Latvijā nav obligāta, ir nepieciešams pētījums, kurš ļaus atklāt aktuālas vakcinācijas tendences un faktorus, kas varētu uzlabot vakcinācijas pārklājumu. Mērķis: Šī pētījuma mērķis bija vakcināciju tendenču salīdzinājums priekšlaikus un laikā dzimušiem bērniem ar anonīmas vecāku aptauju. Metodoloģija: Bērnu (līdz pieciem gadiem) vecāki aizpildīja anketu (bērnu vecumu, dzimumu, dzimšanas datus un veselības stāvokli, pēcdzemdību hospitali…

Infection by Influenza Virus in Childhood: A Call for Broader Influenza Vaccination

2004

Efficiency of Biolistic DNA Vaccination in Experimental Type I Allergy

2012

Gene gun-mediated delivery of allergen-encoding plasmid DNA has been in focus for many years now as being a needle-free alternative to the protein-based desensitization regimen used in specific immunotherapy. Biolistic immunization with the Helios gene gun has proven to be potent in the induction of antigen-specific CD4(+) and CD8(+) T cells. Here we describe biolistic vaccination in experimental mouse models of IgE-mediated type I allergy as well as allergen-induced airway inflammation.

BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2

2020

AbstractA safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived immunogens. BNT162b1 encodes a soluble, secreted, trimerised receptor-binding domain (RBD-foldon). BNT162b2 encodes the full-length transmembrane spike glycoprotein, locked in its prefusion conformation (P2 S). The flexibly tethered RBDs of the RBD-foldon bind ACE2 with high avidity. Approximately 20% of the P 2S trimers are in the two-RBD ‘down,’ one-RBD ‘up’ state. In mi…