Search results for "vasculature"
showing 10 items of 12 documents
Analysis of normal human retinal vascular network architecture using multifractal geometry
2017
AIM To apply the multifractal analysis method as a quantitative approach to a comprehensive description of the microvascular network architecture of the normal human retina. METHODS Fifty volunteers were enrolled in this study in the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and January 2014. A set of 100 segmented and skeletonised human retinal images, corresponding to normal states of the retina were studied. An automatic unsupervised method for retinal vessel segmentation was applied before multifractal analysis. The multifractal analysis of digital retinal images was made with computer algorithms, applying the standard box-counting method. Statistical analyse…
Mitochondrial targeting as a novel therapy for stroke
2018
Stroke is a main cause of mortality and morbidity worldwide. Despite the increasing development of innovative treatments for stroke, most are unsuccessful in clinical trials. In recent years, an encouraging strategy for stroke therapy has been identified in stem cells transplantation. In particular, grafting cells and their secretion products are leading with functional recovery in stroke patients by promoting the growth and function of the neurovascular unit – a communication framework between neurons, their supply microvessels along with glial cells – underlying stroke pathology and recovery. Mitochondrial dysfunction has been recently recognized as a hallmark in ischemia/reperfusion neur…
Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature
2012
Background— Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The current study was designed to utilize cardiac micro–computed tomography (micro-CT) technology as a novel imaging strategy, to define the 3-dimensional coronary circulation in the young and aged heart and its relationship to LV fibrosis and function. Methods and Results— Young (2 months old; n=10) and aged (20 months old; n=10) Fischer rats unde…
Flowers and inflorescences of the seagrassPosidonia(Posidoniaceae, Alismatales)
2012
Premise of the study: The predominantly aquatic order Alismatales displays a highly variable fl ower groundplan associated with a diverse range of developmental patterns. We present the fi rst detailed description of fl ower anatomy and development in Posidonia , the sole genus of the seagrass family Posidoniaceae. Existing accounts provide confl icting interpretations of fl oral and infl orescence structure, so this investigation is important in clarifying morphological evolution within this early-divergent monocot order. • Methods: We investigated two species of Posidonia using light microscopy and scanning electron microscopy. Our observations are interpreted in the framework of a recent…
β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
2017
Cerebral ischemic stroke is a main cause of chronic disability. However, there is currently no effective treatment to promote recovery from stroke-induced neurological symptoms. Recent studies suggest that after stroke, immature neurons, referred to as neuroblasts, generated in a neurogenic niche, the ventricular-subventricular zone, migrate toward the injured area, where they differentiate into mature neurons. Interventions that increase the number of neuroblasts distributed at and around the lesion facilitate neuronal repair in rodent models for ischemic stroke, suggesting that promoting neuroblast migration in the post-stroke brain could improve efficient neuronal regeneration. To move t…
Investigating the Vascular Toxicity Outcomes of the Irreversible Proteasome Inhibitor Carfilzomib
2020
Background: Carfilzomib&rsquo
Biomaterials and bioactive molecules to drive differentiation in striated muscle tissue engineering
2015
International audience; The generation of engineered tissues and organs has entered into the clinical practice in response to the chronic lack of organ donors. In particular, for the skeletal and cardiac muscles the translational potential of tissue engineering approaches has clearly been shown, even though the construction of these tissues lags behind others given the hierarchical, highly organized architecture of striated muscles. Failure of the cardiac tissue leads to cardiovascular diseases, which are the leading cause of death in the developed world (Di Felice et al., 2014). On the other hand, there are many clinical cases where the loss of skeletal muscle due to a traumatic injury, an…
Contrast-Enhanced Magnetic Resonance Angiography of the Pulmonary Vasculature
1998
Magnetic resonance angiography (MRA) has been established as a powerful noninvasive imaging modality. Its applications to the study of the pulmonary vasculature have been hampered by a multitude of factors, such as respiratory and cardiac motion artifacts, saturation problems, long acquisition times
Molecular insights and novel approaches for targeting tumor metastasis
2020
In recent years, due to the effective drug delivery and preciseness of tumor sites or microenvironment, the targeted drug delivery approaches have gained ample attention for tumor metastasis therapy. The conventional treatment approaches for metastasis therapy have reported with immense adverse effects because they exhibited maximum probability of killing the carcinogenic cells along with healthy cells. The tumor vasculature, comprising of vasculogenic impressions and angiogenesis, greatly depends upon the growth and metastasis in the tumors. Therefore, various nanocarriers-based delivery approaches for targeting to tumor vasculature have been attempted as efficient and potential approaches…
Human Visual Perception and Retinal Diseases
2010
Retinal diseases are causing alterations of the visual perception leading sometimes to blindness. For this reason, early detection and diagnosis of retinal pathologies is very important. Using digital image processing techniques, retinal images may be analyzed quickly and computer-assisted diagnosis systems may be developed in order to help the ophthalmologists to make a diagnosis. In this paper we described shortly two computer-assisted systems for the detection of retinal landmarks (optic disc and vasculature) together with a brief introduction to the human visual system and to some alterations of the visual perception caused by retinal diseases.