Search results for "virus"
showing 10 items of 5024 documents
Harnessing HLA‐E‐restricted CD8 T lymphocytes for adoptive cell therapy of patients with severe COVID‐19
2020
SARS-CoV-2 is spreading worldwide, and is a pandemic virus that has infected almost 5 million individuals and causing 300.000 deaths, as of mid-May 2020. Because SARS-CoV-2 is a new virus in humans there are currently no vaccines, monoclonal antibodies (mAbs) or even effective drugs available. Human convalescent plasma transfusion is an option for either prophylactic or therapeutic treatment of COVID-19 patients, but its administration to patients who are affected by severe pulmonary disease is associated with increased risk of transfusion-related acute lung injury (TRALI).
The Management of Dental Practices in the Post-COVID 19 Era: An Economic and Operational Perspective
2020
Background: In order to protect dental teams and their patients during the COVID-19 pandemic, dentists have had to adopt several measures (operating and post-operating procedures) which may increase the total treatment time and costs relating to individual protective measures. This paper will propose a thorough analysis of operating dentistry procedures, comparing the economic performance of the activity in a dental surgery before and after the adoption of these protective measures, which are required to contain the risk of SARS-COV-2 infections. Methods: The economic analysis is articulated in three approaches. Firstly, it assesses a reduction in markup by maintaining current charges (A)
Neurotropism in newborn hamsters of plaque purified measles virus clones
1976
Three plaque purified measles virus clones displayed a different neurotropism in newborn hamsters.
Stay Home, Stay Active with SuperJump®: A Home-Based Activity to Prevent Sedentary Lifestyle during COVID-19 Outbreak
2020
The purpose of this study was to investigate the intensity of SuperJump® workout as a home-based activity for fulfilling physical activity recommendations during COVID-19 home-confinement. Seventeen (males: n = 10; females: n = 7) college students (age: 25.8 ± 2.7 years; height: 1.7 ± 0.1 m; weight: 66.2 ± 12.1 kg) participated in the study. To assess the intensity of the activity (30-min), heart rate (HR), expressed as percentages of age-predicted maximal HR (%HRmax), and session ratings of perceived exertion (sRPE), collected on a CR10 scale, were used. %HRmax data were categorically separated in five classes of intensity according to the American College of Sport…
PGC-1α: a master gene that is hard to master
2012
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in cont…
The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell trans…
2019
The effect of timing of community acquired respiratory virus (CARV) infection after allogeneic hematopoietic stem cell transplant (allo-HCT) is an as yet unsettled issue. We evaluate this issue by including all consecutive allo-HCT recipients with molecularly-documented CARV infection during the first year after transplant. The study cohort was drawn from a prospective longitudinal survey of CARV in allo-HCT recipient having respiratory symptoms conducted from December 2013 to December 2018 at two Spanish transplant centers. Respiratory viruses in upper and/or lower respiratory specimens were tested using multiplex PCR panel assays. The study cohort comprised 233 allo-HCT recipients with 37…
A Multivariate Age-Structured Stochastic Model with Immunization Strategies to Describe Bronchiolitis Dynamics
2021
Bronchiolitis has a high morbidity in children under 2 years old. Respiratory syncytial virus (RSV) is the most common pathogen causing the disease. At present, there is only a costly humanized monoclonal RSV-specific antibody to prevent RSV. However, different immunization strategies are being developed. Hence, evaluation and comparison of their impact is important for policymakers. The analysis of the disease with a Bayesian stochastic compartmental model provided an improved and more natural description of its dynamics. However, the consideration of different age groups is still needed, since disease transmission greatly varies with age. In this work, we propose a multivariate age-struct…
Sarcopenia and Covid-19: A New Entity?
2021
As the world comes into terms with the persistent existence of the coronavirus disease 19 (COVID-19) pandemic, the scientific and medical communities have started shifting their attention to the long-term side effects of the disease. Specialists have acknowledged that numerous COVID-19 survivors, especially those who suffered severe complications and endured prolonged bedrest, may require continuous monitoring and rehabilitative care. In this chapter, the authors discuss factors that may predispose individuals to acute sarcopenia secondary to COVID-19 infection or sarcopenic obesity secondary to altered diet and physical activity from prolonged confinement. Challenges in nutrition are highl…
Effect of physical activity on COVID-19 symptoms: A narrative review
2021
In 2019, a new condition caused by the COVID-19, became a global pandemic, presenting a disparate symptomatological picture. The immune response to the virus depends on multiple factors, making the practice of physical exercise an important enhancer of the immune system, but it is unknown what effects it could have on the very different symptoms. In order to achieve and summarize the most outstanding information on the influence of the different types and parameters of physical exercise on the immune system and symptoms presented by COVID-19, it was decided to carry out a review of the literature in the databases PubMed and Medline until August 2020. The results showed that while high inten…
Safety of in-neonatal intensive care unit administration of rotavirus vaccination among preterms
2020
Abstract Background Rotavirus is among the most common vaccine preventable illness in children under 5 years old. Despite increased severity of rotaviral illness in early infancy, most neonatal intensive care units (NICUs) do not administer rotavirus vaccination. The present project aims to evaluate the safety of in-neonatal intenive care unit administration of the monovalent live, attenuated rotavirus vaccination to preterm newborns in Sicily. Methods From the first of March 2018 within the six most important NICUs of Sicily (three located in Palermo, two in Catania and one in Messina), and under the scientific coordination of the University of Palermo and of the Regional Health Department…