Search results for "wt"
showing 10 items of 5424 documents
Analysis of a parabolic cross-diffusion population model without self-diffusion
2006
Abstract The global existence of non-negative weak solutions to a strongly coupled parabolic system arising in population dynamics is shown. The cross-diffusion terms are allowed to be arbitrarily large, whereas the self-diffusion terms are assumed to disappear. The last assumption complicates the analysis since these terms usually provide H 1 estimates of the solutions. The existence proof is based on a positivity-preserving backward Euler–Galerkin approximation, discrete entropy estimates, and L 1 weak compactness arguments. Furthermore, employing the entropy–entropy production method, we show for special stationary solutions that the transient solution converges exponentially fast to its…
Rewards, changes and challenges in the role of primary headteachers/principals in England and Finland
2012
Drawing on an analysis of education policies and qualitative research data, the impact of education reform on the roles of English primary headteachers and their Finnish counterparts is examined and compared. Global forces have resulted in similar policy trends in both countries but owing to contrasting cultural values and education traditions there are marked differences in the mechanisms for change at both national and local levels. However, irrespective of globalisation and differing national contexts, there were considerable similarities in the perspectives of headteachers and principals on the rewards and constraints of their role and the realities of leadership and management.
Senescence-associated HSP60 expression in normal human skin fibroblasts
2005
Normal mammalian fibroblasts cultured in vitro undergo a limited number of divisions before entering a senescent phase in which they can be maintained for long periods but cannot be induced to divide. Senescent cells become unresponsive to growth-promoting signals and exhibit senescent cell morphology with flattened and enlarged cell shape. Several chaperones have a direct effect on cellular senescence. HSP60 has been largely studied in our laboratories and it has been associated with uncontrolled cell proliferation in tumor cells. Since senescence is firmly regulated during cell cycle progression, we wanted to investigate HSP60 protein level during cellular senescence. Our data show that H…
The dual role of p53: DNA protection and antioxidant.
2011
The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 is not only involved in cancer, but also in ageing. p53 is stimulated by stress, which in turn results in the activation of a wide range of transcriptional targets. Low-intensity stress will activate p53 in a manner which results in antioxidant response, thus protecting against ageing because of its antioxidant function. On the contrary, high-intensity activation of p53 will re…
Nicotine-induced FGF-2 mRNA in rat brain is preserved during aging
2004
Indirect trophic actions of nicotine on brain during aging are suggested from observations describing nicotine as a cognitive enhancer, increasing vigilance and improving learning and memory, and both in vitro and in vivo models have demonstrated neuroprotective effects of nAChR agonists. Previously, we have reported that an acute intermittent (-)nicotine treatment significantly increases fibroblast growth factor-2 (FGF-2) mRNA and protein in several brain regions of rat brain. The present study was designed to analyse if nicotine-induced FGF-2 expression in the rat brain was preserved during aging. Using in situ hybridization and quantitative RNase protection assay the present paper report…
Histone Variant MacroH2A1 Marks Liver Aging and Orchestrates the Escape from Senescence Induced by DNA Hypomethylation in Hepatocellular Carcinoma
2015
The epigenetic basis of age-associated progression of liver diseases towards hepatocellular carcinoma (HCC) is unclear. MacroH2A1 is a variant of histone H2A1, present in the two isoforms, with fundamental roles in cell homeostasis. MacroH2A1 is a marker of senescence associated heterochromatic foci (SAHF) and synergizes with DNA demethylating chemotherapic agent 5-aza-2'-deoxycytidine (5-aza-dC) in silencing tumor suppressor genes in human fibroblasts. We show that protein levels of macroH2A1 isoforms are increased in the livers of old rodents and humans, and in human HCC tissue. Human HCC cells overexpressing macroH2A1 escape a 5-aza-dC-induced senescent phenotype, as determined by cell p…
Imbalance between sympathetic and sensory innervation in peritoneal endometriosis
2011
To investigate possible mechanisms of pain pathophysiology in patients with peritoneal endometriosis, a clinical study on sensory and sympathetic nerve fibre sprouting in endometriosis was performed. Peritoneal lesions (n= 40) and healthy peritoneum (n= 12) were immunostained and analysed with anti-protein gene product 9.5 (PGP 9.5), anti-substance P (SP) and anti-tyrosine hydroxylase (TH), specific markers for intact nerve fibres, sensory nerve fibres and sympathetic nerve fibres, respectively, to identify the ratio of sympathetic and sensory nerve fibres. In addition, immune cell infiltrates in peritoneal endometriotic lesions were analysed and the nerve growth factor (NGF) and interleuki…
Expression of vascular endothelial growth factor receptors in the endometrium of septate uterus.
2008
Objective To compare the messenger RNA (mRNA) expression of vascular endothelial growth factor (VEGF) receptors (KDR, Flt-1, and sflt) in the different endometrial locations of septate uterus and normal uterus. Design Prospective, observational study. Setting University teaching hospital. Patient(s) Twelve women with complete septate uterus undergoing hysteroscopic metroplasty and 12 women with normal uterus. Intervention(s) Endometrial tissue samples were obtained from the endometrium covering the septum and the endometrium lining the lateral wall of the uterus. Moreover, endometrial samples were obtained from patients with normal uterus. Main Outcome Measure(s) Differences in the mRNA exp…
A class of quasi-Newton generalized Steffensen methods on Banach spaces
2002
AbstractWe consider a class of generalized Steffensen iterations procedure for solving nonlinear equations on Banach spaces without any derivative. We establish the convergence under the Kantarovich–Ostrowski's conditions. The majorizing sequence will be a Newton's type sequence, thus the convergence can have better properties. Finally, a numerical comparation with the classical methods is presented.
Algebras with intermediate growth of the codimensions
2006
AbstractLet F be a field of characteristic zero and let A be an F-algebra. The polynomial identities satisfied by A can be measured through the asymptotic behavior of the sequence of codimensions and the sequence of colengths of A. For finite dimensional algebras we show that the colength sequence of A is polynomially bounded and the codimension sequence cannot have intermediate growth. We then prove that for general nonassociative algebras intermediate growth of the codimensions is allowed. In fact, for any real number 0<β<1, we construct an algebra A whose sequence of codimensions grows like nnβ.