0000000000000288
AUTHOR
Jörg Habermann
Chemistry of glycopeptides
For a long time, peptides and proteins on the one hand and carbohydrates on the other have been considered separate classes of natural products. The rather strict distinction between these major fields of natural product chemistry is still apparent not only in the organisation of chemistry text books but also in the different approaches to immunological and cell biological recognition phenomena.
Solid-phase synthesis of a glycopeptide from the homophilic recognition domain of epithelial cadherin 1 using a O-pentafluorophenyluronium salt
Abstract The β-turn forming glycopeptide 6 from the homophilic recognition domain of mouse epithelial cadherin 1 carrying a T N -antigen side chain was synthesised on solid phase using an allylic anchor and the new coupling reagent N , N - N ′, N ′-bis(tetramethylene)- O -pentafluorophenyluronium hexafluorophosphate 3 .
Fragment condensation on solid-phase in the synthesis of an amphiphilic glycopeptide from the homophilic recognition domain of epithelial cadherin 1
Abstract The lipo-glycopeptide 6 containing the homophilic recognition motif of mouse epithelial cadherin 1 was synthesised via a fragment condensation on a solid phase linked peptide using an allylic anchor and a pentafluorophenol-based coupling reagent.
Induction of Cell Differentiation in Transformed Keratinocytes by Synthetic (Glyco)peptides from the Homophilic Recognition Domain of E-Cadherin
ChemInform Abstract: Glycopeptide Synthesis Using O-Pentafluorophenyluronium Salts as Novel Condensing Reagents.
Pentafluorophenyluronium salts and related coupling reagents for the solid-phase synthesis of peptides and glycopeptides have been developed and employed in the synthesis of a glycopeptide sequence from the cell adhesion molecule E-CAD 1.