0000000000066914

AUTHOR

Fritz Poustka

showing 10 related works from this author

Fragile-X carrier females: evidence for a distinct psychopathological phenotype?

1996

The present study examined 35 mothers (29 premutation carriers) of children with fragile-X syndrome in measures of intelligence and psychiatric disorders by comparing them with two control groups: a) 30 mothers of children in the general population and b) 17 mothers of non-fra-X retarded children with autism. Premutation carriers had a higher frequency of affective disorders than mothers from the general population. Preliminary data indicate that normally intelligent premutation carriers of the fra-X genetic abnormality have a similar frequency of affective disorders (DSM-III-R criteria [APA, 1987]) than mothers of autistic children. Neither carriers of the premutation nor carriers of the f…

AdultHeterozygotePopulationIntelligenceMothersSchizoaffective disorderTrinucleotide RepeatsReference ValuesIntellectual DisabilitymedicineHumansSchizophreniform disorderAutistic DisordereducationChildGenetics (clinical)education.field_of_studybusiness.industryWechsler ScalesMiddle Agedmedicine.diseaseFragile X syndromeSchizophreniaFragile X SyndromeMutationSchizophreniaAutismAge of onsetbusinessClinical psychologyPsychopathologyAmerican journal of medical genetics
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Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults : a pilot study

2012

Food & nutrition research 56, 8 S. (2012). doi:10.3402/fnr.v56i0.10941

medicine.medical_specialtyChild and Adolescent Psychiatry; Medicine;lcsh:TX341-641leptin receptor (sOB-R)leptinanorexia nervosaInternal medicineMedicineddc:610Young adultResearch dataNutrition and DieteticsLeptin receptorbusiness.industryAnorexia nervosa; leptin; leptin receptor (sOB-R); free leptin index (FLI); zincLeptinzincfungidigestive oral and skin physiologyPublic Health Environmental and Occupational HealthControl subjectsfree leptin index (FLI)EndocrinologyAnorexia nervosa (differential diagnoses)Eating disordersOriginal ArticleAnimal studiesNutrition researchbusinesslcsh:Nutrition. Foods and food supplyhormones hormone substitutes and hormone antagonistsFood Science
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Erfasst der FBT lokale visuelle Informationsverarbeitung bei Autismus-Spektrum-Störungen?

2010

Fragestellung: Der kognitive Phänotyp von Autismus-Spektrum-Störungen (ASS) ist unter anderem durch eine Neigung zu lokaler Informationsverarbeitung (schwacher zentraler Kohärenz) gekennzeichnet. Es wurde untersucht, ob der Fragmentierte Bilder Test (FBT) diese Präferenz zu erfassen vermag. Methodik: Die FBT-Leistungen 15 autistischer, 16 depressiver und 16 schizophrener Patienten sowie von 16 typisch entwickelten Kontrollpersonen wurden verglichen. Mit dem Embedded Figures Test (EFT) und dem Mosaiktest (MT) wurden ebenfalls validierte Tests lokaler Informationsverarbeitung erhoben. Ergebnisse: Patienten mit ASS zeigten eine Präferenz für lokale Informationsverarbeitung, d. h. Beeinträchti…

GynecologyPsychiatry and Mental healthClinical Psychologymedicine.medical_specialtyReference valuesPediatrics Perinatology and Child HealthmedicineGeneral MedicinePsychologyZeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
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Zytogenetische Veränderungen durch Methylphenidat?

2006

Zusammenfassung: Fragestellung: Wegen des Verdachts, dass Methylphenidat (MPH) zytogenetische Veränderungen beim Menschen induzieren könnte, wird der Einsatz dieser Substanz kontrovers debattiert. Die Diskussion wurde ausgelöst durch eine Studie von El-Zein et al. (2005) , die bei zwölf Kindern nach dreimonatiger Behandlung mit MPH eine signifikante Häufung chromosomaler Aberrationen, Schwesterchromatiden-Austausche und Kleinkerne fanden. Methodik: Die vorliegende Arbeit diskutiert die Untersuchung von El-Zein et al. unter Berücksichtigung gegenwärtig geltender zytogenetischer Standards und ordnet sie ein in den Zusammenhang bisheriger Studien zur Mutagenität, Klastogenität und Kanzerogeni…

GynecologyPsychiatry and Mental healthClinical Psychologymedicine.medical_specialtybusiness.industryPediatrics Perinatology and Child HealthmedicineGeneral MedicinebusinessZeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
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Differences in Serum Zn Levels in Acutely Ill and Recovered Adolescents and Young Adults with Anorexia Nervosa - A Pilot Study

2011

Preliminary evidence suggests that changes in zinc (Zn) metabolism are associated with anorexia nervosa (AN). However, data are scarce regarding potential differences in serum Zn concentrations in adolescent and young adult patients with AN. It was the aim of the present pilot study to compare serum Zn concentrations between acutely ill and remitted adolescent and young adult female patients with AN and female controls. Zn concentrations were higher in remitted compared with acutely ill patients. Zn concentrations were also higher in remitted patients compared with controls, but there was no significant difference in Zn concentrations between acutely ill patients and controls. The present s…

medicine.medical_specialtySignificant differencePhysiologymedicine.diseasePsychiatry and Mental healthClinical PsychologyEating disordersEndocrinologyAnorexia nervosa (differential diagnoses)Internal medicineFemale patientmedicineYoung adultPsychologyEuropean Eating Disorders Review
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Neuropsychological profiles of FMR-1 premutation and full-mutation carrier females

1999

Abstract The present French–German investigation of fragile-X syndrome (fra-X) was undertaken to disentangle genetic from environmental effects on cognitive performance as assessed with the following measures: Wechsler Adult Intelligence Scale-Revised (WAIS-R), Wisconsin Card Sorting Test, Trail-Making Test, Tower of Hanai, Verbal Fluency Test, Stroop Test, short-term and consolidation memory, and the d2 task. Groups with different genotypes ( n =11 mothers with a full mutation in the FMR-1 gene of fra-X children; n =65 mothers with a premutation in the FMR-1 gene of fra-X children; n =18 siblings of these mothers with normal CGG repeats) and with different psychosocial stressors from fra-X…

medicine.diagnostic_testIntelligence quotientCognitive disorderWechsler Adult Intelligence ScaleNeuropsychological testmedicine.diseaseDevelopmental psychologyPsychiatry and Mental healthWisconsin Card Sorting TestmedicineVerbal fluency testEffects of sleep deprivation on cognitive performancePsychologyBiological PsychiatryClinical psychologyStroop effectPsychiatry Research
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

2013

AM Vicente - Cross-Disorder Group of the Psychiatric Genomics Consortium Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in …

Netherlands Twin Register (NTR)MedizinInheritance PatternsSocial SciencesAUTISM SPECTRUM DISORDERSnosologyheritabilityCOMMON SNPS0302 clinical medicineCrohn DiseaseSCHIZOPHRENIAChildPsychiatric geneticsGenetics & HeredityMAJOR DEPRESSIVE DISORDERRISK0303 health sciencesATTENTION-DEFICIT/HYPERACTIVITY DISORDER120 000 Neuronal CoherenceMental DisordersVariantsBIPOLAR DISORDERASSOCIATIONGenomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3]Psychiatric DisordersCROHNS-DISEASE3. Good healthSchizophreniagenetic association studyMedical geneticsMajor depressive disorderSNPsAdultmedicine.medical_specialtygenetic etiologymedical geneticsDEFICIT HYPERACTIVITY DISORDERBiologyPolymorphism Single Nucleotidebehavioral disciplines and activitiesArticleGenomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3]HeritabilityGenetic Heterogeneity03 medical and health sciencesPrevalence of mental disordersmental disorders/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyGeneticsmedicineddc:61HumansAttention deficit hyperactivity disorderGenetic Predisposition to Disease[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyDCN PAC - Perception action and control NCEBP 9 - Mental healthddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersBipolar disorderPsychiatry030304 developmental biologyDepressive Disorder MajorGenome HumanGenetic heterogeneitymedicine.diseaseschizophreniaAttention Deficit Disorder with HyperactivityChild Development Disorders PervasivePerturbações do Desenvolvimento Infantil e Saúde Mental030217 neurology & neurosurgeryGenome-Wide Association Study
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Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

2015

G.B. and S.N. acknowledge funding support for this work from the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. P.H.L. is supported by US National Institute of Mental Health (NIMH) grant K99MH101367. Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an an…

Netherlands Twin Register (NTR)Statistical methodsAutismMedizinLOCIGenome-wide association studyheritabilityGenome-wide association studiesHistonesGenètica mèdica0302 clinical medicineHistone methylationDatabases Genetic2.1 Biological and endogenous factorsPsychologyGWASAetiologyPsychiatric geneticsR2Cbipolar disorderPsychiatry0303 health sciencesDisordersLociDepressionGeneral NeuroscienceMental DisordersMedical geneticsMETHYLATIONBrain3rd-DASSerious Mental IllnessPsychiatric Disorders3. Good healthHistoneMental HealthSchizophreniaMental DisorderCognitive Sciences[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]PromotersBDCBURDENRC0321 Neuroscience. Biological psychiatry. NeuropsychiatryHumanSignal Transductionmedicine.medical_specialtyDISORDERSGenomicsNetwork and Pathway Analysis Subgroup of Psychiatric Genomics ConsortiumBurdenBiologyMethylationArticleBiological pathwayPROMOTERS03 medical and health sciencesDatabasesGeneticmedicineGenetics/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansGenetic Predisposition to Diseasehistone methylationBipolar disorderPsiquiatriaAUTISMPsychiatry030304 developmental biologyGenetic associationNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]Neurology & NeurosurgeryNeuroscience (all)Human GenomeNeurosciencesmedicine.diseaseBrain DisordersGood Health and Well BeingDE-NOVO MUTATIONSPerturbações do Desenvolvimento Infantil e Saúde MentalRC0321SchizophreniaGenome-wide Association StudiesDe-novo mutationsmajor depressionNeuroscience030217 neurology & neurosurgeryGenome-Wide Association Study
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Systematic screening for mutations in the promoter and the coding region of the 5-HT1A gene.

1995

In the present study we sought to identify genetic variation in the 5-HT{sub 1A} receptor gene which through alteration of protein function or level of expression might contribute to the genetic predisposition to neuropsychiatric diseases. Genomic DNA samples from 159 unrelated subjects (including 45 schizophrenic, 46 bipolar affective, and 43 patients with Tourette`s syndrome, as well as 25 healthy controls) were investigated by single-strand conformation analysis. Overlapping PCR (polymerase chain reaction) fragments covered the whole coding sequence as well as the 5{prime} untranslated region of the 5-HT{sub 1A} gene. The region upstream to the coding sequence we investigated contains a …

GeneticsSilent mutationMutationBipolar DisorderBase SequenceMolecular Sequence DataNucleic acid sequenceBiologyGene mutationmedicine.disease_causeReceptors SerotoninGenetic variationMutationGenetic predispositionmedicineSchizophreniaCoding regionHumansGeneReceptors Serotonin 5-HT1Genetics (clinical)Polymorphism Single-Stranded ConformationalTourette SyndromeAmerican journal of medical genetics
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Differences in serum zinc levels in acutely ill and remitted adolescents and young adults with bulimia nervosa in comparison with healthy controls &a…

2017

Neuropsychiatric disease and treatment 2017(13), 2621-2630 (2017). doi:10.2147/NDT.S137549

050103 clinical psychologymedicine.medical_specialtyNeuropsychiatric Disease and Treatment610bulimia nervosaReference rangeeating disordersGastroenterology03 medical and health sciencesremission0302 clinical medicineInternal medicineMedicineserum concentrations0501 psychology and cognitive sciencesddc:610Young adultOriginal ResearchSerum zincbusiness.industryBulimia nervosazinc05 social sciencesSerum concentrationmedicine.disease030227 psychiatryEating disordersEndocrinologyAnorexia nervosa (differential diagnoses)Prospective researchbusinessNeuropsychiatric Disease and Treatment
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