0000000000077650

AUTHOR

José Luis Zamorano

showing 10 related works from this author

Cardiac manifestations of Anderson-Fabry disease: results from the international Fabry outcome survey.

2007

Aims Anderson–Fabry disease (AFD) is an uncommon X-linked disorder caused by deficient activity of the lysosomal enzyme α-galactosidase A. The Fabry Outcome Survey is a European database designed to monitor the long-term efficacy and safety of enzyme replacement therapy (ERT) with agalsidase alfa. The aim of this study was to determine the prevalence and characteristics of cardiac disease in AFD patients. Methods and results Clinical and laboratory data were available in 714 patients from 11 countries (mean age 35 ± 17 years, 369 women, 336 treated). The prevalence of angina was 23 vs. 22%; palpitations and arrhythmias 27 vs. 26%; exertional dyspnoea 23 vs. 23%; and syncope 2 vs. 4%, in wom…

AdultMalemedicine.medical_specialtyHeart diseaseHeart DiseasesCardiomyopathyLeft ventricular hypertrophySyncopeAnginaRisk FactorsInternal medicinemedicinePalpitationsPrevalenceHumansVascular diseasebusiness.industryEnzyme replacement therapyMiddle Agedmedicine.diseaseFabry diseaseRecombinant ProteinsSurgeryEuropeIsoenzymesDyspneaTreatment OutcomeEchocardiographyalpha-GalactosidaseFabry DiseaseFemaleHypertrophy Left Ventricularmedicine.symptomCardiology and Cardiovascular MedicinebusinessGlomerular Filtration RateEuropean heart journal
researchProduct

Echocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study

2017

International audience; Aims - To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results - A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean…

MaleLongitudinal straindeformation imaging[SDV]Life Sciences [q-bio]Sex Factor030204 cardiovascular system & hematologyStandard deviationVentricular Function LeftHeart Ventricle2D echocardiography0302 clinical medicineReference ValuesNuclear Medicine and ImagingImage Processing Computer-AssistedMedicineCircumferential strainAge FactorReference Value030212 general & internal medicineMultivariate Analysi2D echocardiography; Adult echocardiography; Deformation imaging; Reference values; Radiology Nuclear Medicine and Imaging; Cardiology and Cardiovascular MedicineObserver VariationStrain (chemistry)Age FactorsGeneral MedicineMiddle AgedHealthy VolunteerHealthy VolunteersEuropeHomogeneousEchocardiographyRadiology Nuclear Medicine and imagingCardiologyLinear ModelFemaleRadiologyCardiology and Cardiovascular MedicineRadial stressHumanAdultmedicine.medical_specialtyadult echocardiographyHeart Ventricles03 medical and health sciencesSex FactorsInternal medicineHumansRadiology Nuclear Medicine and imaging2d strainbusiness.industryMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREReference valuesMultivariate AnalysisLinear Modelsbusiness
researchProduct

Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study

2015

International audience; AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 ± 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions…

MaleAgingLeft030204 cardiovascular system & hematologyDoppler echocardiographyVentricular Function LeftNORRE StudyCohort Studies0302 clinical medicineDiastoleReference ValuesNuclear Medicine and ImagingVentricular Function030212 general & internal medicineDoppler echocardiography; NORRE Study; reference values; systolic and diastolic function; Adult; Age Factors; Aged; Aging; Cohort Studies; Diastole; Echocardiography Doppler; Europe; Female; Healthy Volunteers; Heart Ventricles; Humans; Male; Middle Aged; Reference Values; Sex Factors; Systole; Ventricular Function Left; Young Adult; Radiology Nuclear Medicine and Imaging; Cardiology and Cardiovascular Medicinesystolic and diastolic functionmedicine.diagnostic_testDopplerAge FactorsGeneral MedicineMiddle AgedEchocardiography DopplerHealthy VolunteersCardiovascular physiologyEuropemedicine.anatomical_structureEchocardiographyCardiologysymbolsFemale[SDV.IB]Life Sciences [q-bio]/BioengineeringRadiologyCardiology and Cardiovascular MedicineDoppler effectCohort studyAdultmedicine.medical_specialtySystoleHeart VentriclesDiastole03 medical and health sciencessymbols.namesakeYoung AdultSex FactorsInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingSystoleAgedbusiness.industryreference valueDoppler echocardiographyVentricleReference valuesbusiness
researchProduct

Echocardiographic reference ranges for normal cardiac chamber size: Results from the NORRE study

2014

AimsAvailability of normative reference values for cardiac chamber quantitation is a prerequisite for accurate clinical application of echocardiography. In this study, we report normal reference ranges for cardiac chambers size obtained in a large group of healthy volunteers accounting for gender and age. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following chamber quantitation protocols approved by the European Association of Cardiovascular Imaging.MethodsA total of 734 (mean age: 45.8 ± 13.3 years) healthy volunteers (320 men and 414 women) were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORR…

MaleLower blood pressureSex FactorHeart VentricleCohort StudiesChamber size and function; Reference values; Two-dimensional echocardiography; Cardiology and Cardiovascular Medicine; Radiology Nuclear Medicine and Imaging; Medicine (all)Nuclear Medicine and ImagingAge FactorReference ValueYoung adultBody surface areaObserver VariationMedicine (all)Age FactorsGeneral MedicineStroke volumeMiddle AgedEchocardiographyCardiologyFemaleCardiology and Cardiovascular MedicineRadiologyHumanCohort studyAdultmedicine.medical_specialtyHeart VentriclesReproducibility of ResultChamber size and functionRisk AssessmentReference valuesYoung AdultSex FactorsTwo-dimensional echocardiographyInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingHeart AtriaAgedbusiness.industryReproducibility of ResultsMean ageStroke VolumeMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREOriginal ArticlesCardiac chamberReference valuesCohort Studiebusiness
researchProduct

Practical guidance for combination lipid-modifying therapy in high- and very-high-risk patients: A statement from a European Atherosclerosis Society …

2021

International audience; Background and aimsThis European Atherosclerosis Society (EAS) Task Force provides practical guidance for combination therapy for elevated low-density lipoprotein cholesterol (LDL-C) and/or triglycerides (TG) in high-risk and very-high-risk patients.MethodsEvidence-based review.ResultsStatin-ezetimibe combination treatment is the first choice for managing elevated LDL-C and should be given upfront in very-high-risk patients with high LDL-C unlikely to reach goal with a statin, and in primary prevention familial hypercholesterolaemia patients. A proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor may be added if LDL-C levels remain high. In high and very-h…

0301 basic medicinemedicine.medical_specialtyStatinSettore MED/09 - Medicina InternaCombination therapymedicine.drug_classHigh-risk2019 ESC/EAS Dyslipidaemia GuidelineLipid goal030204 cardiovascular system & hematologyTriglyceride03 medical and health sciences0302 clinical medicineCombined treatmentcardiovascular diseaseInternal medicinemedicineHumanstriglycerides2019 ESC/EAS Dyslipidaemia Guidelines; combination treatment; LDL cholesterol; triglycerides; lipid goals; high-risk; cardiovascular diseaselipid goalsbusiness.industryTask forceAnticholesteremic AgentsPCSK9Cholesterol LDL[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismAtherosclerosis2019 ESC/EAS Dyslipidaemia Guidelines3. Good health030104 developmental biologyDiabetes Mellitus Type 2Combination treatmentAtherosclerosiLDL cholesterolEuropean atherosclerosis societyKexinlipids (amino acids peptides and proteins)Proprotein Convertase 9Hydroxymethylglutaryl-CoA Reductase InhibitorsCardiology and Cardiovascular MedicinebusinessVery high risk
researchProduct

Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

2020

Abstract Aims  To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. Methods and results  A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were −15.0% in men and −15.6% in women for epicardial strain, −16.8% …

AdultMalemedicine.medical_specialtyadult echocardiographydeformation imagingHeart Ventricles030204 cardiovascular system & hematologyVentricular Function LeftReference values2D echocardiography03 medical and health sciences0302 clinical medicine[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicinereference values.Healthy volunteersmedicineHumansRadiology Nuclear Medicine and imaging030212 general & internal medicineEndocardiumNormal rangeStrain (chemistry)business.industryMyocardiumHealthy subjectsreference valueMean ageGeneral MedicineMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREMiddle AgedApex (geometry)EchocardiographyCardiology[SDV.IB]Life Sciences [q-bio]/BioengineeringFemalebusinessLarge groupCardiology and Cardiovascular MedicineEndocardiumHuman
researchProduct

3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study

2017

International audience; Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2)…

AdultMalemedicine.medical_specialtyLongitudinal strainadult echocardiographydeformation imagingHeart VentriclesCardiac VolumeDiastoleEchocardiography Three-Dimensional030204 cardiovascular system & hematologyVentricular Function LeftHeart VentricleReference values03 medical and health sciencesYoung Adultleft ventricular function0302 clinical medicineInternal medicineHealthy volunteersthree-dimensional echocardiographyMedicineCircumferential strainHumansRadiology Nuclear Medicine and imagingReference Value030212 general & internal medicineSystoleAgedEjection fractionStrain (chemistry)business.industryGeneral MedicineMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREMiddle AgedHealthy VolunteerHealthy Volunteers3. Good healthRadiology Nuclear Medicine and imagingReference valuesCardiologyFemale[SDV.IB]Life Sciences [q-bio]/BioengineeringbusinessCardiology and Cardiovascular MedicineHuman
researchProduct

Two-dimensional transthoracic echocardiographic normal reference ranges for proximal aorta dimensions: Results from the EACVI NORRE study

2017

International audience; AIMS: To report normal reference ranges for echocardiographic dimensions of the proximal aorta obtained in a large group of healthy volunteers recruited using state-of-the-art cardiac ultrasound equipment, considering different measurement conventions, and taking into account gender, age, and body size of individuals. METHODS AND RESULTS: A total of 704 (mean age: 46.0 ± 13.5 years) healthy volunteers (310 men and 394 women) were prospectively recruited from the collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was obtained in all subjects following pre-defined protocols. Aortic…

MaleAorta ThoracicSex Factor030204 cardiovascular system & hematologyReproducibility of resultCohort Studies0302 clinical medicineDiastoleMedicineThoracic aortaAge FactorReference ValueProspective Studies030212 general & internal medicineMultivariate AnalysiBody surface areaCardiac cycleAge FactorsGeneral MedicineNORRE studyMiddle AgedHealthy VolunteerHealthy VolunteersEuropeEchocardiographyNORRE study; echocardiography; reference values; reproducibility of results; sinus of valsalva; thoracic aortaCardiologyLinear Model[SDV.IB]Life Sciences [q-bio]/BioengineeringFemaleCardiology and Cardiovascular MedicineHumanAdultmedicine.medical_specialtySystoleDiastoleNormal valuesThoracic aortaReference values03 medical and health sciencesYoung AdultSex FactorsInternal medicinemedicine.arteryAscending aortaHumansRadiology Nuclear Medicine and imagingMeasurement methodAortaAnalysis of Variancebusiness.industrySinus of valsalvaReproducibility of ResultsMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREProspective StudieMultivariate AnalysisLinear ModelsCohort Studiebusiness
researchProduct

Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study

2019

International audience; Aims - To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results - A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indic…

Malemedicine.medical_specialtyadult echocardiographyWork efficiency030204 cardiovascular system & hematology2D echocardiography03 medical and health sciences0302 clinical medicineReference ValuesInternal medicinemedicine.arteryHealthy volunteersMedicineHumansRadiology Nuclear Medicine and imaging2D echocardiography; adult echocardiography; myocardial work; reference values.Prospective StudiesBrachial arteryadult echocardiography • 2D echocardiography • myocardial work • reference valuesbusiness.industryNon invasiveHealthy subjectsreference valueMean ageGeneral MedicineMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREMiddle Agedmyocardial workEuropeBlood pressureEchocardiographyHeart Function TestsCardiologyFemale[SDV.IB]Life Sciences [q-bio]/BioengineeringCardiology and Cardiovascular MedicinebusinessLarge group[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
researchProduct

Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function

2020

Abstract Aims The present study sought to evaluate the correlation between indices of non-invasive myocardial work (MW) and left ventricle (LV) size, traditional and advanced parameters of LV systolic and diastolic function by 2D echocardiography (2DE). Methods and results A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from LV pressure-strain loops using custom software. Peak LV pressure was estimated non-invasively from brachial ar…

AdultMalemedicine.medical_specialtySystoleadult echocardiographyDiastoleSpeckle tracking echocardiography030204 cardiovascular system & hematologyadult echocardiography; myocardial strain; myocardial work; speckle tracking echocardiographyVentricular Function LeftCorrelationVentricular Dysfunction Left03 medical and health sciences0302 clinical medicineDiastoleInternal medicinemedicineHumansRadiology Nuclear Medicine and imaging030212 general & internal medicineSystolespeckle tracking echocardiographyEjection fractionbusiness.industryWork (physics)Stroke VolumeMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREGeneral MedicineMiddle Agedmyocardial workmedicine.anatomical_structureBlood pressureEchocardiographyVentriclemyocardial strainCardiology[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieCardiology and Cardiovascular Medicinebusiness
researchProduct