0000000000114540
AUTHOR
A. Bockisch
Quantitative Determination of Renal 99mTc-MAG3 Clearance. A Comparison of Results Acquired Simultaneously in Whole Body Geometry and with a Gamma Camera in ROI-Technique
289 patients were simultaneously investigated with a partially shielded whole body counter (Oberhausen) and in camera technique to correlate the values of the MAG3-clearance. Good correlation was found for the often used times schedules of taking blood samples. Late blood samples increase high clearance values in both methods slighly. The shape of the ROI has no influence using camera technique. We conclude, that camera technique can replace the Oberhausen method with a partially shielded whole body counter.
Technetium-99m mercaptoacetyltriglycine clearance: reference values for infants and children.
Six hundred and thirty-nine clearance studies performed in children aged 7 days to 19 years utilizing technetium-99m mercaptoacetyltriglycine (MAG 3) were retrospectively analysed. Standardized conditions for the investigation included: parenteral hydration (60 ml/hxm2 body surface) in addition to normal oral fluid intake, weight-related dose of99mTc-MAG 3 (1 MBq/kg body weight, minimum 15 MBq) and calculation of clearance according to Bubeck et al. Of the 513 children, 169 included in this analysis could be classified as “normal” with regard to their renal function. Normal kidney function was judged by the following criteria: normal GFR for age, normal tubular function (absence of proteinu…
Rezeptordarstellung mit der Single Photonen Emissions Computertomographie (SPECT): Stand der Forschung und Perspektiven
123-Jod markierte Liganden ermoglichen die Darstellung und semiquantitative Messung cerebraler Rezeptoren mit der Single Photonen Emissions Computertomographie (SPECT).
Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study.
To study the efficacy of coumarin/troxerutine for the protection of salivary glands and mucosa during irradiation. Design: Prospective, randomized, placebo-controlled, double-blind trial. Setting: University hospital, Germany. Patients: 48 patients who had radiotherapy to the head and neck. Main outcome measures: Salivary gland scintigraphy and acute side-effects of radiotherapy (Radiation Therapy Oncology Group (RTOG) score). Results: 23 patients (11 experimental, 12 placebo) completed the study. The global efficacy measure combining scintigraphy and RTOG score favoured the experimental arm (P= 0.07). The RTOG score showed significantly fewer acute side-effects of radiation in the experime…
Benzodiazepinrezeptordarstellung mit JOMAZENIL-SPECT
Die Darstellung der Benzodiazepin-Rezeptordichte (BZD) mit der Single- Photonen-Emissions-Computertomographie (SPECT) wurde durch die Synthese des neuen Radioliganden JOMAZENIL ermoglicht. JOMAZENIL entspricht dem mit Jod-123 markierten Benzodiazepin-Antagonisten Flumazenil und zeichnet sich durch eine hochspezifische Bindung an zentralen BZ-Rezeptoren aus. Verdrangungsexperimente zeigten, das 90–110 Minuten p.i. ca. 80% der Aktivitat der spezifischen Bindung entsprechen [1].
Bedeutung der Ganzkörper-Skelettszintigraphie im Rahmen des Staging von Malignomen im HNO-Bereich*
Concerning malignant tumours of the oral cavity, pharynx and larynx, bone metastases are in general rarely seen. For the specification to which patients the whole body bone scintigraphy as detection method should be applied, the findings of 370 patients were analysed retrospectively. In respect of primary staging, bone metastases could be found by scintigraphy in only 1.4% of the patients. On the other hand, there was a detection rate of 12% during the further course of the disease, especially in case of clinical symptoms pointing at spreading metastases or in tumour recurrences. Nevertheless, positive scan findings which were not due to metastases could be found in both groups with equal f…
Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT. A preliminary report.
Single photon emission tomography (SPECT) imaging of the central benzodiazepine receptor (BZr) became possible with the newly developed ligand 123I-IOMAZENIL. The BZr binding was investigated in ten patients with panic disorder (PP) compared to ten epileptic patients (EP). Panic patients had lower IOMAZENIL uptake rates in the frontal, occipital and temporal cortex than EP indicating the involvement of the BZr complex in panic disorder.
Benzodiazepinrezeptorbindung im [123I]-IOMAZENIL-SPECT in Relation zu Cortisol-Plasmaspiegeln
Mit Iomazenil, dem mit 123Iod markierten Benzodiazepinantagonisten, und der Single Photonen Emissions Tomographie (SPECT) ist die in vivo-Darstellung von Benzodiazepinrezeptoren (BZR) moglich. Wir fanden in fruheren Untersuchungen eine signifikante Verminderung der lomazenil-Bindung bei Panikpatienten im Vergleich zu Patienten mit Depressionen (Schlegel et al. 1994). Zwischen dem GABA/BZR-System und Cortisol sind vielfaltige und komplexe Wirkzusammenhange beschrieben worden (De Souza et al. 1990). Nach Adrenalektomie wurde bei Ratten eine Zunahme der BZR-Dichte beschrieben (Miller et al. 1988, Acuna et al. 1990). Diese Effekte waren nach Corticosteroidgabe reversibel. Wahrend sich der Effek…
Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT
By the application of 123([123I]IBZM), an iodine-labelled dopamine D2-receptor antagonist, brain D2 receptors in humans can be visualized with single photon emission computed tomography (SPECT). The ratio of IBZM binding to striatal regions versus binding to frontal cortex (ST/FC ratio) provided a semiquantitative measurement of D2 receptor binding in the striatum. This study investigated the relationship between receptor occupancy and plasma prolactin levels in 12 male patients treated with haloperidol, benperidol or clozapine. Prolactin levels were positively correlated with D2 receptor occupancy, reflecting at least in part a comparable dopamine receptor antagonism in different dopaminer…
[123I]IBZM SPECT in patients treated with typical and atypical neuroleptics: relationship to drug plasma levels and extrapyramidal side effects
[123I]Iodobenzamide (IBZM) is an iodine-labeled dopamine receptor ligand and can be used to visualize brain D2 receptors in humans with single photon emission computerized tomography (SPECT). The ratio of striatal IBZM uptake to uptake in frontal cortex (ST/FC ratio) represents a semiquantitative measure of D2 receptor binding in the striatum. Our study sample included six patients treated with haloperidol (3.0-8.0 mg/day orally; one patient with an average of 0.9 mg/day intramuscularly), five patients with benperidol (9.0-15.0 mg/day orally) and nine patients treated with clozapine (200.0-600.0 mg/day orally). Typical neuroleptics (TNs) and atypical neuroleptics (ANs) were significantly di…