6533b821fe1ef96bd127b029

RESEARCH PRODUCT

Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study.

R KohnenG.g. BelzP. WüstenbergJoachim KutznerWilfried WagnerA. BockischBilal Al-nawasH. H. Henneicke-von ZepelinBelal Naser-hijaziKnut A. Grötz

subject

AdultMalemedicine.medical_specialtymedicine.medical_treatmentRadiation-Protective AgentsPlaceboGastroenterologyXerostomiaSalivary GlandsSialadenitislaw.inventionRandomized controlled trialDouble-Blind MethodlawCoumarinsInternal medicinemedicineMucositisHumansProspective StudiesProspective cohort studyRadiation InjuriesRadionuclide ImagingAgedSodium Pertechnetate Tc 99mbusiness.industryHead and neck cancerMouth MucosaMiddle Agedmedicine.diseaseSialadenitisSurgeryRadiation therapyDrug CombinationsHydroxyethylrutosideTreatment OutcomeOtorhinolaryngologyEpidermoid carcinomaHead and Neck NeoplasmsSurgeryFemaleOral SurgeryCranial IrradiationRadiopharmaceuticalsbusiness

description

To study the efficacy of coumarin/troxerutine for the protection of salivary glands and mucosa during irradiation. Design: Prospective, randomized, placebo-controlled, double-blind trial. Setting: University hospital, Germany. Patients: 48 patients who had radiotherapy to the head and neck. Main outcome measures: Salivary gland scintigraphy and acute side-effects of radiotherapy (Radiation Therapy Oncology Group (RTOG) score). Results: 23 patients (11 experimental, 12 placebo) completed the study. The global efficacy measure combining scintigraphy and RTOG score favoured the experimental arm (P= 0.07). The RTOG score showed significantly fewer acute side-effects of radiation in the experimental arm (P< 0.05). Conclusion: The results suggest that coumarin/troxerutine have a favourable effect in the treatment of radiogenic sialadenitis and mucositis.

yearjournalcountryeditionlanguage
2001-02-01The British journal of oralmaxillofacial surgery
10.1054/bjom.2000.0459https://pubmed.ncbi.nlm.nih.gov/11178853