Vesikoureteraler und vesikorenaler Reflux

Unterschieden wird zwischen primarem und sekundarem vesikoureteralem und vesikorenalem Reflux. Ja nach Auspragung und Erweiterung auch des Nierenbeckenkelchsystems wird der Reflux nach der International Reflux Study Group in 5 Grade eingeteilt. Der primare Reflux ist durch eine (anatomisch-funktionelle) Storung des ureterovesikalen Ubergangs bedingt, er kann sich mit dem Wachstum des Kindes ruckbilden. Zur Diagnostik gehoren Sonografie, MCU zur Darstellung des Refluxes und der DMSA-Scan zur Dokumentation von Parenchynarben. Ziel der Therapie ist die Vermeidung von Parenchymnarben. Die Therapie ist von den Risikofaktoren abhangig (Alter und Geschlecht des Kindes, Blasen und Darmentleerungsst…

A Search for IceCube Events in the Direction of ANITA Neutrino Candidates

During the first three flights of the Antarctic Impulsive Transient Antenna (ANITA) experiment, the collaboration detected several neutrino candidates. Two of these candidate events were consistent with an ultra-high-energy up-going air shower and compatible with a tau neutrino interpretation. A third neutrino candidate event was detected in a search for Askaryan radiation in the Antarctic ice, although it is also consistent with the background expectation. The inferred emergence angle of the first two events is in tension with IceCube and ANITA limits on isotropic cosmogenic neutrino fluxes. Here, we test the hypothesis that these events are astrophysical in origin, possibly caused by a po…

PND25 Burden of Spina Bifida (SB) in Germany - the Characteristics of SB Population

Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study

Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012. Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n = 88) and 2.2 years in those treated with zoledronate (n = 218). Multiv…

Weiter- und Fortbildung

Resource utilization and productivity loss in persons with spina bifida—an observational study of patients in a tertiary urology clinic in Germany.

Background and purpose To investigate resource use and burden associated with spina bifida (SB) in Germany. Methods A questionnaire was used to obtain information on SB-related healthcare resource use and assistive technologies used for the last 1 and 10 years. Individuals with SB were recruited at a tertiary specialist clinic. To participate, persons with SB required the cognitive ability to respond or a caregiver to answer questions on their behalf. They could use personal medical charts or other records to answer. The analyses included assessment of frequency and extent of resource use for both time frames. Results Data on 88 persons with a diagnosis of SB were collected (44% female). Du…

Combined sensitivity to the neutrino mass ordering with JUNO, the IceCube Upgrade, and PINGU

Physical review / D 101(3), 032006 (1-19) (2020). doi:10.1103/PhysRevD.101.032006

Diagnostischer Work-up bei Neugeborenen mit Harntransportstörungen

Seit Einfuhrung der pranatalen Sonographie und deren Etablierung in der Schwangerschaftsvorsorge sowie durch die im Rahmen des neonatalen Screenings erhobenen Daten werden Urologen und Padiater zunehmend haufiger mit fraglich pathologischen Befunden des Urogenitaltrakts konfrontiert. Gleichzeitig wuchs in den letzten Jahren das Angebot sowohl qualitativer als auch quantitativer diagnostischer bildgebender Systeme. Daraus ergibt sich die Forderung nach einem effizienten diagnostischen Vorgehen, das moderne bildgebende Verfahren integriert und die Belastung fur das Kind (Strahlen, Invasivitat) reduziert.

Computational Techniques for the Analysis of Small Signals in High-Statistics Neutrino Oscillation Experiments

The current and upcoming generation of Very Large Volume Neutrino Telescopes – collecting unprecedented quantities of neutrino events – can be used to explore subtle effects in oscillation physics, such as (but not restricted to) the neutrino mass ordering. The sensitivity of an experiment to these effects can be estimated from Monte Carlo simulations. With the high number of events that will be collected, there is a trade-off between the computational expense of running such simulations and the inherent statistical uncertainty in the determined values. In such a scenario, it becomes impractical to produce and use adequately-sized sets of simulated events with traditional methods, such as M…

Constraints on Minute-Scale Transient Astrophysical Neutrino Sources

High-energy neutrino emission has been predicted for several short-lived astrophysical transients including gamma-ray bursts (GRBs), core-collapse supernovae with choked jets, and neutron star mergers. IceCube's optical and x-ray follow-up program searches for such transient sources by looking for two or more muon neutrino candidates in directional coincidence and arriving within 100 s. The measured rate of neutrino alerts is consistent with the expected rate of chance coincidences of atmospheric background events and no likely electromagnetic counterparts have been identified in Swift follow-up observations. Here, we calculate generic bounds on the neutrino flux of short-lived transient so…

PND23 Economic Burden of Illness for Persons With Spina Bifida (SB) in Germany