showing 9 related works from this author
Studies of the physicochemical and structural properties of self-assembling cationic pyridine derivatives as gene delivery agents.
2015
New amphiphilic pyridine derivatives containing dodecyloxycarbonyl substituents at positions 3 and 5 and cationic moieties at positions 2 and 6 have been designed and synthesised. Compounds of this type can be considered as synthetic lipids. The corresponding 1,4-dihydropyridine (1,4-DHP) derivatives have earlier been proposed as a promising tool for plasmid DNA (pDNA) delivery in vitro. In this work studies of the self-assembling properties of amphiphilic pyridine derivatives leading to the formation of liposomes, determination of particle size, zeta-potential and critical micelle concentration (CMC) with dynamic light scattering (DLS) measurements are described. Furthermore, thermal analy…
ChemInform Abstract: Synthesis and Self-Assembly of Novel Fluorous Cationic Amphiphiles with a 3,4-Dihydro-2(1H)-pyridone Spacer.
2011
Abstract The synthesis of fluorous (highly fluorinated) 3,4-dihydro-2(1 H )-pyridone-5-carboxylate cationic amphiphiles have been described, where the dihydropyridone serves as a spacer and either a pyridinium bromide or a triphenylphosphonium bromide form the polar cationic head group. The in water self-assembled aggregates have been observed by atomic force microscopy (AFM) and dynamic light scattering (DLS).
Magnetic field driven micro-convection in the Hele-Shaw cell: the Brinkman model and its comparison with experiment
2015
International audience; The micro-convection caused by the ponderomotive forces of the self-magnetic field in a magnetic fluid is studied here both numerically and experimentally. The theoretical approach based on the general Brinkman model substantially improves the description with respect to the previously proposed Darcy model. The predictions of both models are here compared to finely controlled experiments. The Brinkman model, in contrast to the Darcy model, allows us to describe the formation of mushrooms on the plumes of the micro-convective flow and the width of the fingers. In the Brinkman approach, excellent quantitative agreement is also obtained for the finger velocity dynamics …
Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines
2019
The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. We have revealed that the mean diameter of freshly prepared nanoparti…
Synthesis and self-assembly of novel fluorous cationic amphiphiles with a 3,4-dihydro-2(1H)-pyridone spacer
2011
Abstract The synthesis of fluorous (highly fluorinated) 3,4-dihydro-2(1 H )-pyridone-5-carboxylate cationic amphiphiles have been described, where the dihydropyridone serves as a spacer and either a pyridinium bromide or a triphenylphosphonium bromide form the polar cationic head group. The in water self-assembled aggregates have been observed by atomic force microscopy (AFM) and dynamic light scattering (DLS).
Evaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomes
2021
This study was focused on the estimation of the targeted modification of 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties of 1,4-DHP (C12, C14 and C16)
Magnetic field driven micro-convection in the Hele-Shaw cell
2013
AbstractMicro-convection caused by ponderomotive forces of the self-magnetic field of a magnetic fluid in the Hele-Shaw cell under the action of a vertical homogeneous magnetic field is studied both experimentally and numerically. It is shown that a non-potential magnetic force at magnetic Rayleigh numbers greater than the critical value causes fingering at the interface between the miscible magnetic and non-magnetic fluids. The threshold value of the magnetic Rayleigh number depends on the smearing of the interface between fluids. Fingering with its subsequent decay due to diffusion of particles significantly increases the mixing at the interface. Velocity and vorticity fields at fingering…
Swarming of micron-sized hematite cubes in a rotating magnetic field -- Experiments
2020
Energy input by under-field rotation of particles drives the systems to emergent non-equilibrium states. Here we investigate the suspension of rotating magnetic cubes. Micron-sized hematite cubes are synthesized and observed microscopically. When exposed to a rotating magnetic field, they form rotating swarms that interact with each other like liquid droplets. We describe the swarming behaviour and its limits and characterize swarm size and angular velocity dependence on magnetic field strength and frequency. A quantitative agreement with a theoretical model is found for the angular velocity of swarms as a function of field frequency. It is interesting to note that hematite particles with p…
Gene delivery agents possessing antiradical activity: self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives
2013
Seventeen 1,4-dihydropyridine (1,4-DHP) amphiphiles including differently substituted pyridinium, pyrazinium, N-methyl piperidinium or N-methyl morpholinium moieties as the cationic head-group of the molecule have been designed and synthesised. 1,4-DHP amphiphiles have been earlier proposed as a promising tool for plasmid DNA (pDNA) delivery in vitro. In this work the ability of the 1,4-DHP amphiphiles to self-assemble, to bind pDNA and to transfer it into the cells as well as the cytotoxicity of 1,4-DHP amphiphiles–pDNA complexes was studied. Furthermore, antiradical activity (ARA) of the 1,4-DHP derivatives was determined. We have revealed that all new 1,4-DHP amphiphiles possessed self-a…