0000000000126209
AUTHOR
G. Kellermann
Further studies on associations between leprosy and genetic markers in human serum.
Seven serum proteins were typed on a sample of 910 individuals from Angola, Africa. The sample consisted of both leprosy patients and healthy controls from the same geographical area. Significant associations with leprosy were found for the Hp and Pi systems. The results are discussed.
On the genetics of the pi serum proteins.
The authors report family studies (51 families with 134 children) on the inheritance of the Pi phenotypes. Combining these data with a Norwegian family material (77 families with 323 children) published by Fagerhol and Gedde-Dahl (1969) a total of 128 families with 457 children is now available, which allows the following conclusion: The Pi phenotypes are inherited by a simple codominant mode of heredity and they are determined by a set of (at least nine) alleles. As up to now no exception to the role of inheritance has been observed, the application of the Pi system in cases of disputed paternity seems to be discussible. Some methodological problems in connection with this are shown.
Further studies on the AB0-typing of ancient bones
This paper deals with the AB0-typing of bone material from the 14th century. From 151 femora, 126 gave a positive reaction, the rest did not react at all. 53.9% A, 16.7% B, 23.8% H and 5.6% AB are the respective results. Some hypotheses suggesting relations between infectious diseases and AB0 blood groups are discussed. The AB0 distribution seems to point to an association with plague and smallpox.
Hp, Gc, Cp, Tf, Bg and Pi phenotypes in leprosy patients and healthy controls from West Bengal (India)
On a sample of n=601 leprous individuals and n=386 healthy controls from West Bengal (India) the question is discussed, if there are existing any associations between leprosy and several serum protein groups like haptoglobin, Gc, ceruloplasmin, transferrin, β2 I and Pi. No associations were found concerning the haptoglobins and transferrins. Certain associations came out respecting ceruloplasmin, β2 I and Pi phenotypes. However, these associations, which were found in connection with the different types and clinical courses of leprosy, should be reexamined by further research. The most striking results were obtained concerning the Gc proteins. In accordance with previously performed investi…
Study of some serum group systems in the Mahishyas and the Muslims in 24-Parganas district, West Bengal
A survey of serum Pi, Cp, Hp and Tf was carried out in 104 Bengali Hindu Mahishya and 123 Bengali Muslim of West Bengal, India.
Zur Anwendbarkeit des Pi-Systems in der Vaterschaftsbegutachtung
In der vorliegenden Arbeit wird die Brauchbarkeit des Pi-Systems fur die Gutachterpraxis diskutiert. Berucksichtigt man die geringe Ausschluswahrscheinlichkeit (0,05) und die Schwierigkeiten, die sich bei der exakten Bestimmung einiger Phanotypen ergeben, so scheint das Pi-System nur von geringer forensischer Brauchbarkeit zu sein.
Investigations on the population genetics of the alpha-1-antitrypsin polymorphism.
The results of Pi-typing on 2647 individuals from 9 populations are reported. Of the 17 phenotypes and 9 alleles described in literature, we found 12 phenotypes and 8 alleles. The population smaples differ characteristically in their allele frequencies. The allle PiM appears constantly in all populations tested with a frequency of more than 0.85. The alleles PiF (0.01–0.11), PiS (0.01–0.02) and PiZ (0.01–0.02) were also relatively frequent in all samples. All the other alleles remain below 0.01. A great increase in the number of Pi-variants was observed in the Central European area. The frequency of α1-at variants in various populations is discussed.
Associations between leprosy and serum protein groups
Serum protein group typings were done on a sample of n=173 adult healthy Negroes from the Macua tribe in Mozambique and on n=129 leprous individuals from the same tribe. Unfortunately, the type of leprosy is not known. Whilst between leprosy and haptoglobins, transferrins and Pi proteins no associations could be observed, statistically significant associations between leprosy and ceruloplasmin resp. β2 I were found. It is pointed out that these associations should be confirmed by further research on other populations and with respect to type and process of leprosy, until biological and population genetical interpretations will be possible.
Methodological investigations on the AB0-Typing of ancient bones
This investigation deals with the possibility and the attempt to find a reliable method for AB0-typing of ancient bones. Using the Ouchterlonytest and the Immunorheophoresis we got satisfying reactions. Typing 169 femora from the 15th to 17th centuries from the Charnel house in Oppenheim, the following results were obtained: 36.2% A, 22.8% B, 10.1% AB and 30.9% H. 20 femora (11.8%) did not react at all. Presumably these samples belonged to nonsecretors who possess no blood group active material in their secretions and tissues. Compared with the present distribution of ABH-phenotypes and alleles the allele B showed a higher percentage.
On the population genetics of the ceruloplasmin polymorphism
The frequencies of Cp-variants in 3 European, 1 Asiatic and 3 African populations are reported. The most striking fact is the high incidence of the CpA-allele not only in the African but also in 2 European samples.