6533b7d8fe1ef96bd126a38e
RESEARCH PRODUCT
Hp, Gc, Cp, Tf, Bg and Pi phenotypes in leprosy patients and healthy controls from West Bengal (India)
J. KrügerM. BajatzadehM. R. ChakravarttiH. WalterG. Kellermannsubject
Serum proteinIndiaGene FrequencyLeprosyGeneticsmedicineHumansMetabolic diseaseGenetics (clinical)Glycoproteinschemistry.chemical_classificationPolymorphism GeneticHaptoglobinsbiologyHaptoglobinTransferrinCeruloplasminPi phenotypesmedicine.diseasePhenotypechemistryTransferrinImmunologybiology.proteinSerum GlobulinsWest bengalLeprosyFactor Analysis StatisticalCeruloplasmindescription
On a sample of n=601 leprous individuals and n=386 healthy controls from West Bengal (India) the question is discussed, if there are existing any associations between leprosy and several serum protein groups like haptoglobin, Gc, ceruloplasmin, transferrin, β2 I and Pi. No associations were found concerning the haptoglobins and transferrins. Certain associations came out respecting ceruloplasmin, β2 I and Pi phenotypes. However, these associations, which were found in connection with the different types and clinical courses of leprosy, should be reexamined by further research. The most striking results were obtained concerning the Gc proteins. In accordance with previously performed investigations on Brazilians and in particular on Negroes from Mocambique statistically high significant surplusses of Gc 1-1 phenotypes in individuals suffering from leprosy could be demonstrated. This indicates in our opinion the existence of a relationship between Gc proteins and leprosy, which, however, must also be disclosed by further genetical and especially by pathophysiological research.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1972-01-01 | Human Genetics |