0000000000178299
AUTHOR
Iveta Vesere
ChemInform Abstract: Synthesis and Self-Assembly of Novel Fluorous Cationic Amphiphiles with a 3,4-Dihydro-2(1H)-pyridone Spacer.
Abstract The synthesis of fluorous (highly fluorinated) 3,4-dihydro-2(1 H )-pyridone-5-carboxylate cationic amphiphiles have been described, where the dihydropyridone serves as a spacer and either a pyridinium bromide or a triphenylphosphonium bromide form the polar cationic head group. The in water self-assembled aggregates have been observed by atomic force microscopy (AFM) and dynamic light scattering (DLS).
Synthesis and self-assembly of novel fluorous cationic amphiphiles with a 3,4-dihydro-2(1H)-pyridone spacer
Abstract The synthesis of fluorous (highly fluorinated) 3,4-dihydro-2(1 H )-pyridone-5-carboxylate cationic amphiphiles have been described, where the dihydropyridone serves as a spacer and either a pyridinium bromide or a triphenylphosphonium bromide form the polar cationic head group. The in water self-assembled aggregates have been observed by atomic force microscopy (AFM) and dynamic light scattering (DLS).
Aminoskābes saturošu 1,4-dihidropiridīnu un to analogu sintēze
Aminoskābes saturošu 1,4-dihidropiridīnu un to analogu sintēze. Vesere I., zinātniskie vadītāji Dr. ķīm., vadošā pētniece Vīgante B., Dr. ķīm., asoc. prof. Sūna E. Maģistra darbs, 64 lappuses, 19 attēli, 2 tabulas, 1 pielikums, 117 literatūras avoti. Latviešu valodā. Darba teorētiskajā daļā apkopota informācija par dihidropiridīniem, to īpašībām un farmakoloģisko aktivitāti. Izpētīta aktivēto esteru iegūšana, amīdsaites veidošanās starp skābes grupu un aminoskābes slāpekļa grupu, kā arī tiolsaites veidošanās starp skābes grupu un aminoskābē esošo sēra atomu. Apkopota informācija par niacīna receptoriem un ligandiem. Darba gaitā sintezēta 5-(metoksikarbonil)-2,6-dimetil-4-(3-nitrofenil)-1,4-…