0000000000194656
AUTHOR
Vicente Bodí
Evidencias de la revascularización en el infarto agudo de miocardio
Resumen La reperfusion precoz es la clave en el manejo de los pacientes con sindrome coronario agudo con elevacion del ST. Cuanto antes se consiga la reperfusion coronaria, mejor es el pronostico. Segun la evidencia cientifica, la intervencion coronaria percutanea primaria es superior a la fibrinolisis en cuanto a morbilidad y mortalidad y es el tratamiento de eleccion siempre que el retraso a la intervencion coronaria no vaya a superar los 90–120 min. Cuando el retraso a la reperfusion con intervencion coronaria percutanea va a ser largo (> 120 min), se recomienda iniciar el tratamiento con fibrinolisis. Por lo tanto, una limitacion muy importante para la adecuada implementacion de la inte…
Antithrombotic Therapy in Elderly Patients with Acute Coronary Syndromes
The treatment of acute coronary syndrome (ACS) in elderly patients continues to be a challenge because of the characteS.G.B.ristics of this population and the lack of data and specific recommendations. This review summarizes the current evidence about critical points of oral antithrombotic therapy in elderly patients. To this end, we discuss the peculiarities and differences reported referring to dual antiplatelet therapy (DAPT) in ACS management in elderly patients and what might be the best option considering these population characteristics. Furthermore, we analyze antithrombotic strategies in patients with atrial fibrillation (AF), with a particular focus on those cases that also presen…
Changes in the spatial distribution of the Purkinje network after acute myocardial infarction in the pig
Purkinje cells (PCs) are more resistant to ischemia than myocardial cells, and are suspected to participate in ventricular arrhythmias following myocardial infarction (MI). Histological studies afford little evidence on the behavior and adaptation of PCs in the different stages of MI, especially in the chronic stage, and no quantitative data have been reported to date beyond subjective qualitative depictions. The present study uses a porcine model to present the first quantitative analysis of the distal cardiac conduction system and the first reported change in the spatial distribution of PCs in three representative stages of MI: an acute model both with and without reperfusion; a subacute …