0000000000214927
AUTHOR
Claudio Viscoli
Association between antifungal prophylaxis and rate of documented bacteremia in febrile neutropenic cancer patients.
Published data have suggested a correlation between antifungal prophylaxis and bacteremia in febrile neutropenia. This correlation was investigated among 3002 febrile neutropenic patients enrolled in 4 trials during 1986-1994. Globally, 1322 patients (44%) did not receive antifungal prophylaxis; 835 (28%) received poorly absorbable antifungal agents and 845 (28%) received absorbable antifungal agents. The rates of bacteremia for these groups were 20%, 26%, and 27%, respectively (P=.0001). In a multivariate model without including antifungal prophylaxis, factors associated with bacteremia were: age, duration of hospitalization, duration of neutropenia before enrollment, underlying disease, p…
Détection d’un disaccharide (MSDS) par spectrométrie de masse. Analyse multicentrique de son intérêt pour le diagnostic des infections fongiques invasives
Introduction Nous avons recemment decrit une methode utilisant la spectrometrie de masse MALDI-TOF pour detecter, identifier et quantifier un disaccharide (MSDS) dont la presence dans le serum est associee aux infections fongiques invasives (IFI). Nos premieres investigations, portant sur des cas de candidoses et d’aspergilloses invasives (IC et IA) recrutes dans notre CHU, ont montre que les performances diagnostiques de cette methode etaient comparables a celles des tests Platelia™ et Fungitell ® et qu’en outre elle permettait de diagnostiquer les mucormycoses (MM) pour lesquelles ces tests serologiques sont en defaut. Cette etude a comme objectif de confirmer ces resultats de maniere mul…
Estimating minimum adult HIV prevalence: A cross-sectional study to assess the characteristics of people living with HIV in Italy
In 2012, we conducted a retrospective cross-sectional study to assess the number of people living with HIV linked to care and, among these, the number of people on antiretroviral therapy. The health authority in each of the 20 Italian Regions provided the list of Public Infectious Diseases Clinics providing antiretroviral therapy and monitoring people with HIV infection. We asked every Public Infectious Diseases Clinic to report the number of HIV-positive people diagnosed and linked to care and the number of those on antiretroviral therapy during 2012. In 2012, 94,146 people diagnosed with HIV and linked to care were reported. The majority were males (70.1%), Italians (84.4%), and aged betw…