0000000000230107
AUTHOR
Guillaume Beltramo
Interstitial Lung Disease during ANCA-Associated Vasculitis: A Poor-Prognosis Factor
IF 7.873; International audience
Le site de pathologie iatrogène pneumotox : données métriques sur les tableaux et médicaments, intéressant potentiellement l’allergologue
Introduction En aout 2018 a ete installee une fonctionnalite de mesure de l’activite sur Pneumotox evaluant le taux de consultation des differents medicaments, tableaux cliniques, ainsi que l’imagerie et l’histologie, de meme que les pays utilisateurs et villes d’origine des utilisateurs, en conformite avec la RGPD. Resultats Au 8 janvier 2019, sur 5 mois, 35 720 connexions ont ete recensees, 9740 (33,6 %) en provenance des Etats-Unis, 3760 de France, 1830 d’Allemagne, 1412 du Canada, 1340 du Bresil, 1320 des Pays-Bas, 1160 du Royaume-Uni, 1090 d’Espagne, 821 de Suisse, 611 d’Italie, 576 de Turquie et 430 de Belgique. Ces chiffres sont a relativiser en fonction de la population du pays, du …
Pulmonary hypertension associated with ponatinib therapy
IF 8.332; International audience; A case of pulmonary hypertension associated with ponatinib therapy in a chronic myelogenous leukaemia patient.
Pleuroparenchymal fibroelastosis as a late complication of chemotherapy agents
To the Editor: We identified six patients with clinical, radiographic and physiological features typical of pleuroparenchymal fibroelastosis (PPFE). In the six cases, PPFE may have been causally related to prior alkylating drugs used to treat malignacy, namely cyclophosphamide in five of the cases and carmustine (BCNU (1,3-bis-(2-chloroethyl)-1-nitrosourea)) in one. Based on an extensive review of the literature, we suspect that similar cases may have already been reported in the past 4 decades but have not been recognised either as PPFE or as drug-induced in nature. In 2004, Frankel et al. [1] described a then-new clinicopathologic entity, which they termed “idiopathic PPFE”. The authors i…
Le pneumocytome sclérosant : une tumeur rare et apparemment bénigne
International audience; Introduction: Sclerosing pneumocytoma is a benign and rare lung tumor affecting epithelial cells. In most cases, patients are asymptomatic and the diagnosis is made on an X ray or a CT scan performed for other enquiry. Sex ratio favors women. Epidemiological studies report that middle-aged Asian women are more frequently affected. Radiological investigations find a solitary nodule or a mass with peripheric localization. When performed, histological analysis shows a tumor composed of at least two of the four following architectures: papillary, sclerosing, hemangiomatous and solid, with two types of cells that can be round or cubic cells.Cases report: We report two cas…
Haemoptysis: a frequent diagnostic challenge
We appreciate and agree with the comments of M. Mondoni and colleagues, that the results of the ongoing prospective Italian multicentre trial ([www.ClinicalTrial.gov][1] identifier [NCT02045394][2]) will be of considerable interest for the management of haemoptysis, a frequent and severe symptom, especially since there is no clear consensus concerning aetiology and treatment. Interestingly, beyond determining the prevalence of diseases that may present with haemoptysis, their epidemiological results will be analysed according to the severity of the symptom. More importantly, their trial will hopefully make it possible to analyse the sensitivity and specificity of complementary tests, such a…
Haemoptysis in adults: a 5-year study using the French nationwide hospital administrative database.
Haemoptysis is a serious symptom with various aetiologies. Our aim was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income country.This retrospective multicentre study was based on the French nationwide hospital medical information database collected over 5 years (2008–2012). We analysed haemoptysis incidence, aetiologies, geographical and seasonal distribution and mortality. We studied recurrence, association with lung cancer and mortality in a 3-year follow-up analysis.Each year, ∼15 000 adult patients (mean age 62 years, male/female ratio 2/1) were admitted for haemoptysis or had haemoptysis as a complication of their hospital s…
Halo Sign and Eosinophilia: What Is Your Diagnosis?
Blood eosinophilia associated with transient and migrating nodules with a halo sign on chest computed tomography scan should suggest larva migrans related to toxocariasis or <i>ascaris suum</i>.
Daptomycin-induced eosinophilic pneumonia: Are there any risk factors?
Abstract Objectives Daptomycin is a widely used antibiotic. Rhabdomyolysis related to daptomycin is one of the adverse effects of treatment, justifying the need for regular monitoring of muscle enzymes throughout treatment. Daptomycin may also lead to eosinophilic pneumonia. However, risk factors for this adverse reaction have not been identified and do not permit targeting of at-risk populations who could benefit from appropriate monitoring. Patients and methods Literature was reviewed for cases of daptomycin-induced eosinophilic pneumonia (DIEP), which that were compared to cases of patients without this adverse effect. Results Fifty patients with DIEP and 54 controls were identified. Age…
Pneumopathies non infectieuses induites par les biothérapies ciblées
Resume Les biotherapies des rhumatismes inflammatoires chroniques ont revolutionne leur prise en charge. Ces nouveaux medicaments sont susceptibles d’induire des effets secondaires multiples, parfois severes et ceux-ci peuvent atteindre l’appareil respiratoire. Les presentations cliniques et radiologiques sont multiples et l’apparition de symptomes respiratoires chez un patient sous biotherapie doit faire suspecter un effet iatrogenique avec au premier plan la survenue de pneumopathies interstitielles diffuses parfois tres severes, de granumolatoses et d’anomalies auto-immunes. La complication infectieuse doit toujours etre eliminee. La demarche est complexe et doit etre rigoureuse ce d’aut…