0000000000236557
AUTHOR
José M. Izquierdo
Assembly of the ribonucleoprotein complex containing the mRNA of the β-subunit of the mitochondrial H+-ATP synthase requires the participation of two distal cis-acting elements and a complex set of cellular trans-acting proteins
The mRNA encoding the beta-subunit of the mitochondrial H(+)-ATP synthase (beta-F1-ATPase) is localized in an approx. 150 nm structure of the hepatocyte of mammals. In the present study, we have investigated the cis- and trans-acting factors involved in the generation of the ribonucleoprotein complex containing beta-F1-ATPase mRNA. Two cis-acting elements (beta1.2 and 3'beta) have been identified. The beta1.2 element is placed in the open reading frame, downstream of the region encoding the mitochondrial pre-sequence of the protein. The 3'beta element is the 3' non-translated region of the mRNA. Complex sets of proteins from the soluble and non-soluble fractions of the liver interact with t…
Extensions, expansions, Lie algebra cohomology and enlarged superspaces
After briefly reviewing the methods that allow us to derive consistently new Lie (super)algebras from given ones, we consider enlarged superspaces and superalgebras, their relevance and some possible applications.
Topics on n-ary algebras
We describe the basic properties of two n-ary algebras, the Generalized Lie Algebras (GLAs) and, particularly, the Filippov (or n-Lie) algebras (FAs), and comment on their n-ary Poisson counterparts, the Generalized Poisson (GP) and Nambu-Poisson (N-P) structures. We describe the Filippov algebra cohomology relevant for the central extensions and infinitesimal deformations of FAs. It is seen that semisimple FAs do not admit central extensions and, moreover, that they are rigid. This extends the familiar Whitehead's lemma to all $n\geq 2$ FAs, n=2 being the standard Lie algebra case. When the n-bracket of the FAs is no longer required to be fully skewsymmetric one is led to the n-Leibniz (or…
On the underlying gauge group structure of D=11 supergravity
The underlying gauge group structure of D=11 supergravity is revisited (see paper for detailed abstract).
The geometry of branes and extended superspaces
We argue that a description of supersymmetric extended objects from a unified geometric point of view requires an enlargement of superspace. To this aim we study in a systematic way how superspace groups and algebras arise from Grassmann spinors when these are assumed to be the only primary entities. In the process, we recover generalized spacetime superalgebras and extensions of supersymmetry found earlier. The enlargement of ordinary superspace with new parameters gives rise to extended superspace groups, on which manifestly supersymmetric actions may be constructed for various types of p-branes, including D-branes (given by Chevalley-Eilenberg cocycles) with their Born-Infeld fields. Thi…
Contractions of Filippov algebras
We introduce in this paper the contractions $\mathfrak{G}_c$ of $n$-Lie (or Filippov) algebras $\mathfrak{G}$ and show that they have a semidirect structure as their $n=2$ Lie algebra counterparts. As an example, we compute the non-trivial contractions of the simple $A_{n+1}$ Filippov algebras. By using the \.In\"on\"u-Wigner and the generalized Weimar-Woods contractions of ordinary Lie algebras, we compare (in the $\mathfrak{G}=A_{n+1}$ simple case) the Lie algebras Lie$\,\mathfrak{G}_c$ (the Lie algebra of inner endomorphisms of $\mathfrak{G}_c$) with certain contractions $(\mathrm{Lie}\,\mathfrak{G})_{IW}$ and $(\mathrm{Lie}\,\mathfrak{G})_{W-W}$ of the Lie algebra Lie$\,\mathfrak{G}$ as…
Hidden supersymmetries in supersymmetric quantum mechanics
We discuss the appearance of additional, hidden supersymmetries for simple 0+1 $Ad(G)$-invariant supersymmetric models and analyse some geometrical mechanisms that lead to them. It is shown that their existence depends crucially on the availability of odd order invariant skewsymmetric tensors on the (generic) compact Lie algebra $\cal G$, and hence on the cohomology properties of the Lie algebra considered.
Superconformal mechanics, black holes, and non-linear realizations
The OSp(2|2)-invariant planar dynamics of a D=4 superparticle near the horizon of a large mass extreme black hole is described by an N=2 superconformal mechanics, with the SO(2) charge being the superparticle's angular momentum. The {\it non-manifest} superconformal invariance of the superpotential term is shown to lead to a shift in the SO(2) charge by the value of its coefficient, which we identify as the orbital angular momentum. The full SU(1,1|2)-invariant dynamics is found from an extension to N=4 superconformal mechanics.
3'-Untranslated regions of oxidative phosphorylation mRNAs function in vivo, as enhancers of translation
Recent findings have indicated that the 3´-untranslated region (3´-UTR) of the mRNA encoding the β-catalytic subunit of the mitochondrial H+-ATP synthase has an in vitro translation-enhancing activity (TEA) [Izquierdo and Cuezva, Mol. Cell. Biol. (1997) 17, 5255–5268; Izquierdo and Cuezva, Biochem. J. (2000) 346, 849–855]. In the present work, we have expressed chimaeric plasmids that encode mRNA variants of green fluorescent protein in normal rat kidney and liver clone 9 cells to determine whether the 3´-UTRs of nuclear-encoded mRNAs involved in the biogenesis of mitochondria have an intrinsic TEA. TEA is found in the 3´-UTR of the mRNAs encoding the α- and β-subunits of the rat H+-ATP syn…
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Seuls les 100 premiers auteurs dont les auteurs INRA ont été entrés dans la notice. La liste complète des auteurs et de leurs affiliations est accessible sur la publication.; International audience; In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues…
Kaluza–Klein theory, AdS/CFT correspondence and black hole entropy
The asymptotic symmetries of the near-horizon geometry of a lifted (near-extremal) Reissner-Nordstrom black hole, obtained by inverting the Kaluza-Klein reduction, explain the deviation of the Bekenstein-Hawking entropy from extremality. We point out the fact that the extra dimension allows us to justify the use of a Virasoro mode decomposition along the time-like boundary of the near-horizon geometry, AdS$_2\times$S$^n$, of the lower-dimensional (Reissner-Nordstrom) spacetime.
k-Leibniz algebras from lower order ones: from Lie triple to Lie l-ple systems
Two types of higher order Lie l-ple systems are introduced in this paper. They are defined by brackets with l > 3 arguments satisfying certain conditions, and generalize the well-known Lie triple systems. One of the generalizations uses a construction that allows us to associate a (2n - 3)-Leibniz algebra pound with a metric n-Leibniz algebra () pound over tilde by using a 2(n - 1)-linear Kasymov trace form for () pound over tilde. Some specific types of k-Leibniz algebras, relevant in the construction, are introduced as well. Both higher order Lie l-ple generalizations reduce to the standard Lie triple systems for l = 3.
Cohomology of Filippov algebras and an analogue of Whitehead's lemma
We show that two cohomological properties of semisimple Lie algebras also hold for Filippov (n-Lie) algebras, namely, that semisimple n-Lie algebras do not admit non-trivial central extensions and that they are rigid i.e., cannot be deformed in Gerstenhaber sense. This result is the analogue of Whitehead's Lemma for Filippov algebras. A few comments about the n-Leibniz algebras case are made at the end.
Two-twistor particle models and free massive higher spin fields
We present D=3 and D=4 models for massive particles moving in a new type of enlarged spacetime, with D-1 additional vector coordinates, which after quantization lead to the towers of massive higher spin (HS) free fields. Two classically equivalent formulations are presented: one with a hybrid spacetime/bispinor geometry and a second described by a free two-twistor dynamics with constraints. After quantization in the D=3 and D=4 cases, the wave functions are given as functions on the SL(2,R) and SL(2,C) group manifolds respectively, and describe arbitrary on-shell momenta and spin degrees of freedom. Finally, the D=6 case and possible supersymmetric extensions are mentioned.
Autophagy
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide…
Erratum
Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; Arozena, AA; Adachi, H; Adams, CM; Adams, PD; Adeli, K; Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghiso, J; Airoldi, EM; Ait-Si-Ali, S; Akematsu, T; Akporiaye, ET; Al-Rubeai, M; Albaiceta, GM; Albanese, C; Albani, D; Albert, ML; Aldudo, J; Algul, H; Alirezaei, M; Alloza, I; Almasan, A; Almonte-Beceril, M; Alnemri, ES; Alonso, C; Altan-Bonnet, N; Altieri, DC; Alvarez, S; Alvarez-Erviti, L; Alves, S; Amadoro, G; Amano, A; Amantini, C; Ambrosio, S; Amelio, I; Amer, AO; Amessou, M; Amon, A; An, Z; Anania, FA; Andersen, SU; Andley, UP; Andreadi, CK; Andrieu-Ab…
-Poincaré supergravities from Lie algebra expansions
Abstract We use the expansion of superalgebras procedure (summarized in the text) to derive Chern–Simons (CS) actions for the ( p , q ) -Poincare supergravities in three-dimensional spacetimes. After deriving the action for the ( p , 0 ) -Poincare supergravity as a CS theory for the expansion osp ( p | 2 ; R ) ( 2 , 1 ) of osp ( p | 2 ; R ) , we find the general ( p , q ) -Poincare superalgebras and their associated D = 3 supergravity actions as CS gauge theories from an expansion of the simple osp ( p + q | 2 , R ) superalgebras, namely osp ( p + q | 2 , R ) ( 2 , 1 , 2 ) .