0000000000245400

AUTHOR

S. Imbesi

showing 3 related works from this author

Fatal multi-organ failure following anaphylactic shock induced by ceftriaxone

2014

In the latest years, based on the wide use of cephalosporins for antibiotic therapy, a large interest focused on the identification of causal relationship of adverse reactions after their prescription. We report a case of fatal anaphylactic shock following the administration of ceftriaxone in a woman who had tolerated the previous exposure to the drug. This case adds a contribution to the few cases reported in literature to further suggest the possibility of severe anaphylaxis after the administration of ceftriaxone even in patients without any previous reaction to this drug.

Adverse drug reaction; Anaphylaxis; Ceftriaxone; Cephalosporins; Multi-organ failure; Shock; Immunology and AllergySettore MED/43 - Medicina LegaleAnaphylaxiCeftriaxoneCephalosporinAdverse drug reactionImmunology and AllergyShockMulti-organ failureAnaphylaxisCephalosporins
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Fatal Anaphylactic Shock Ceftriaxone-Induced in a 4-Year-Old Child

2014

One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures. The allergic pathogenesis is sustained by the clinical data (short time between the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule and probable sensitization) and the postmortem examination findings (polivisceral congestion and intense eosinophilia found in the histological examination).

Malemedicine.medical_specialtymedicine.drug_classCephalosporinDrug Hypersensitivity03 medical and health sciencesFatal Outcome0302 clinical medicineHumansMedicineEosinophilia030216 legal & forensic medicineAnaphylaxisSensitizationRetrospective StudiesHistological examination030201 allergybusiness.industryCeftriaxoneRetrospective cohort studyGeneral Medicinemedicine.diseaseDermatologyAnti-Bacterial Agentsmedicine.anatomical_structureChild PreschoolPediatrics Perinatology and Child HealthEmergency MedicineCeftriaxoneAnaphylactic shockAutopsymedicine.symptombusinessAnaphylaxismedicine.drugPediatric Emergency Care
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Fatal hypersensitivity reaction to an oral spray of flurbiprofen: a case report

2013

Summary What is known and objective Safety of the anti-inflammatory drug flurbiprofen is comparable with that of other non-steroidal anti-inflammatory drugs of the propionic acid class, which are commonly associated with gastrointestinal and renal side effects. Here we report a case of a fatal hypersensitivity reaction to an oral spray of flurbiprofen taken for sore throat. Case summary A 29-year-old man came to the emergency care unit reporting sore throat with an intense burning sensation associated with fever. Pharyngotonsillitis was diagnosed, and local treatment with oral flurbiprofen spray was prescribed. Immediately after using the spray, the patient experienced a severe reaction cha…

AdultMaleoral sprayAllergyAdministration TopicalFlurbiprofenAdministration OralFatal hypersensitivity reaction; oral spray; flurbiprofenadverse Effect; adverse reaction; anti inflammatory; fatal reaction; flurbiprofen; hypersensitivity; NSAID; pharmacovigilance; sprayDrug HypersensitivitySettore MED/43 - Medicina LegalemedicineMaculopapular rashSore throatHumansPharmacology (medical)Fatal hypersensitivity reactionCause of deathPharmacologyAsphyxiabusiness.industryAnti-Inflammatory Agents Non-SteroidalPharyngitismusculoskeletal systemmedicine.diseaseflurbiprofenHypersensitivity reactionAnesthesiaItchinglipids (amino acids peptides and proteins)Oral Spraysmedicine.symptombusinessmedicine.drugJournal of Clinical Pharmacy and Therapeutics
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