6533b830fe1ef96bd129729d
RESEARCH PRODUCT
Fatal Anaphylactic Shock Ceftriaxone-Induced in a 4-Year-Old Child
Sebastiano GangemiSebastiano GangemiMichele NavarraGioacchino CalapaiElvira Ventura-spagnoloViviana CafeoS. ImbesiLivio Milonesubject
Malemedicine.medical_specialtymedicine.drug_classCephalosporinDrug Hypersensitivity03 medical and health sciencesFatal Outcome0302 clinical medicineHumansMedicineEosinophilia030216 legal & forensic medicineAnaphylaxisSensitizationRetrospective StudiesHistological examination030201 allergybusiness.industryCeftriaxoneRetrospective cohort studyGeneral Medicinemedicine.diseaseDermatologyAnti-Bacterial Agentsmedicine.anatomical_structureChild PreschoolPediatrics Perinatology and Child HealthEmergency MedicineCeftriaxoneAnaphylactic shockAutopsymedicine.symptombusinessAnaphylaxismedicine.drugdescription
One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures. The allergic pathogenesis is sustained by the clinical data (short time between the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule and probable sensitization) and the postmortem examination findings (polivisceral congestion and intense eosinophilia found in the histological examination).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-12-17 | Pediatric Emergency Care |